INT173394

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Context Info
Confidence 0.11
First Reported 2003
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.05
Pain Relevance 0.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Itgam) nucleus (Itgam)
Itgam (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Pain 8 96.92 Very High Very High Very High
Neuropathic pain 21 94.60 High High
Spinal nerve ligature 3 89.76 High High
Sciatic nerve 10 85.72 High High
Dorsal horn 5 74.56 Quite High
allodynia 15 67.72 Quite High
Hyperalgesia 4 66.04 Quite High
Spinal cord 23 58.76 Quite High
nerve block 7 23.60 Low Low
Dorsal horn neuron 1 6.40 Low Low
Disease Link Frequency Relevance Heat
Pain 12 96.92 Very High Very High Very High
Neuropathic Pain 39 94.60 High High
Nervous System Injury 95 75.44 Quite High
Hyperalgesia 4 66.04 Quite High
Nociception 20 63.80 Quite High
Adhesions 21 18.76 Low Low
Apoptosis 1 7.44 Low Low
INFLAMMATION 20 5.00 Very Low Very Low Very Low
Injury 12 5.00 Very Low Very Low Very Low
Hypersensitivity 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The reduction by feG of antibody binding for CD11b and CD16b could be due to several factors which include, preventing the mobilization of granule-stored intracellular molecules, promoting their shedding from the cell surface, or altering antibody binding without affecting the amount of CD11b or CD16b expressed on the cell membrane.
Neg (without) Regulation (affecting) of Gene_expression (expressed) of CD11b
1) Confidence 0.11 Published 2003 Journal BMC Immunol Section Body Doc Link PMC152650 Disease Relevance 0 Pain Relevance 0
Unfortunately, many studies defined microglial activation only based on altered expression of Iba1 or OX-42 (CD11b), which lead to controversies when trying to link microglial activation and pain states, because the direct role of Iba1 and CD11b in neuropathic pain genesis is unclear.
Regulation (altered) of Gene_expression (expression) of CD11b associated with pain and neuropathic pain
2) Confidence 0.11 Published 2009 Journal Mol Pain Section Body Doc Link PMC2759920 Disease Relevance 1.05 Pain Relevance 0.91

General Comments

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