INT173395

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Context Info
Confidence 0.25
First Reported 2003
Last Reported 2011
Negated 3
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 1.23
Pain Relevance 2.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Itgam) nucleus (Itgam)
Anatomy Link Frequency
spinal cord 1
microglia 1
Itgam (Rattus norvegicus)
Pain Link Frequency Relevance Heat
analgesia 18 99.08 Very High Very High Very High
Spinal cord 37 97.96 Very High Very High Very High
Sciatic nerve 6 96.76 Very High Very High Very High
Hyperalgesia 10 94.36 High High
Nerve growth factor 125 93.36 High High
epidural 44 92.16 High High
local anesthetic 32 90.00 High High
Analgesic 35 88.84 High High
Neuropathic pain 50 87.16 High High
Inflammation 34 82.76 Quite High
Disease Link Frequency Relevance Heat
Injury 97 99.56 Very High Very High Very High
Hyperalgesia 36 94.36 High High
Neuropathic Pain 56 87.16 High High
INFLAMMATION 42 82.76 Quite High
Nociception 10 80.20 Quite High
Ganglion Cysts 44 75.76 Quite High
Adhesions 21 18.76 Low Low
Nervous System Injury 14 5.00 Very Low Very Low Very Low
Paralysis 12 5.00 Very Low Very Low Very Low
Pain 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
On the contralateral side, the immunoreactivities for both CD11b and GFAP were unchanged among the CCI rats with each treatment (Figure 3b and 3c).


Neg (unchanged) Regulation (unchanged) of CD11b associated with injury
1) Confidence 0.25 Published 2011 Journal Mol Pain Section Body Doc Link PMC3022746 Disease Relevance 0.44 Pain Relevance 0.40
Concomitantly with this analgesia, ropivacaine suppressed the increases in the immunoreactivities of CD11b and glial fibrillary acidic protein in the dorsal spinal cord, as markers of activated microglia and astrocytes, respectively.
Regulation (immunoreactivities) of CD11b in spinal cord associated with spinal cord and analgesia
2) Confidence 0.15 Published 2011 Journal Mol Pain Section Abstract Doc Link PMC3022746 Disease Relevance 0.71 Pain Relevance 1.56
No change in CD11b immunoreactivity was detected in the motor cortex of these animals (Fig. 9e and 9f) and 230.6 +/- 21 microglia mm2 were identified in lamina V of the motor cortex of 5 unoperated rats and 245.3 +/- 22.3 microglia mm2 were found in the motor cortex of rats with 4 week grafts.
Neg (No) Regulation (change) of CD11b in microglia
3) Confidence 0.14 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2829570 Disease Relevance 0.08 Pain Relevance 0.17
The reduction by feG of antibody binding for CD11b and CD16b could be due to several factors which include, preventing the mobilization of granule-stored intracellular molecules, promoting their shedding from the cell surface, or altering antibody binding without affecting the amount of CD11b or CD16b expressed on the cell membrane.
Neg (without) Regulation (affecting) of CD11b
4) Confidence 0.11 Published 2003 Journal BMC Immunol Section Body Doc Link PMC152650 Disease Relevance 0 Pain Relevance 0

General Comments

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