INT173396

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Context Info
Confidence 0.01
First Reported 2003
Last Reported 2003
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.48
Pain Relevance 0.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (GPER, FCGR3B) extracellular region (FCGR3B) cell adhesion (Itgam)
Golgi apparatus (GPER) endoplasmic reticulum (GPER) nucleus (Itgam)
Anatomy Link Frequency
neutrophil 2
GPER (Homo sapiens)
FCGR3B (Homo sapiens)
Itgam (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 34 97.92 Very High Very High Very High
cytokine 4 24.44 Low Low
halothane 8 5.00 Very Low Very Low Very Low
Inflammatory response 4 5.00 Very Low Very Low Very Low
Catecholamine 4 5.00 Very Low Very Low Very Low
corticosteroid 2 5.00 Very Low Very Low Very Low
Nerve growth factor 2 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
ischemia 2 5.00 Very Low Very Low Very Low
agonist 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 38 97.92 Very High Very High Very High
Salivary Gland Disease 4 97.76 Very High Very High Very High
Adhesions 42 44.48 Quite Low
Asthma 6 5.00 Very Low Very Low Very Low
Hypersensitivity 6 5.00 Very Low Very Low Very Low
Necrosis 4 5.00 Very Low Very Low Very Low
Injury 4 5.00 Very Low Very Low Very Low
Cancer 4 5.00 Very Low Very Low Very Low
Anaphylaxis 4 5.00 Very Low Very Low Very Low
Infection 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This study has established that the tripeptide feG, a derivative of a 7 amino acid anti-inflammatory peptide isolated from salivary glands of rats, is a potent (picomolar) inhibitor of neutrophil movement and chemotaxis on human and rat neutrophils. feG reduces the binding of CD11b and CD16b antibodies to neutrophils, and may exerts its anti-inflammatory effects by modifying the activity of these molecules resulting in impaired neutrophil migration into a site of inflammation. feG may have utility in modulating the severity of a variety of inflammatory conditions.


feG Negative_regulation (reduces) of CD16b Binding (binding) of CD11b in neutrophil associated with inflammation and salivary gland disease
1) Confidence 0.01 Published 2003 Journal BMC Immunol Section Body Doc Link PMC152650 Disease Relevance 0.48 Pain Relevance 0.19
By altering FG loop conformation feG may reduce the dimeric association of CD16b and CD11b.
feG Spec (may) Negative_regulation (reduce) of CD16b Binding (association) of CD11b
2) Confidence 0.01 Published 2003 Journal BMC Immunol Section Body Doc Link PMC152650 Disease Relevance 0 Pain Relevance 0

General Comments

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