INT173448

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.53
First Reported 2003
Last Reported 2008
Negated 3
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 0.14
Pain Relevance 0.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Tas1r3) plasma membrane (Tas1r3) signal transducer activity (Tas1r3)
Anatomy Link Frequency
enteroendocrine cells 1
papillae 1
Tas1r3 (Mus musculus)
Pain Link Frequency Relevance Heat
Glutamate 11 86.16 High High
Glutamate receptor 2 51.48 Quite High
tolerance 1 43.04 Quite Low
anesthesia 6 5.00 Very Low Very Low Very Low
vagus nerve 5 5.00 Very Low Very Low Very Low
antagonist 5 5.00 Very Low Very Low Very Low
Neuropeptide 4 5.00 Very Low Very Low Very Low
medulla 4 5.00 Very Low Very Low Very Low
ketamine 3 5.00 Very Low Very Low Very Low
imagery 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hyperglycemia 8 78.44 Quite High
Appetite Loss 1 57.08 Quite High
Impaired Glucose Tolerance 1 43.68 Quite Low
Aids-related Complex 10 42.36 Quite Low
Diabetes Mellitus 10 36.68 Quite Low
Stress 2 11.08 Low Low
Targeted Disruption 22 5.00 Very Low Very Low Very Low
Sprains And Strains 14 5.00 Very Low Very Low Very Low
Aggression 4 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Expression studies have revealed that taste cells either coexpress T1R1 and T1R3 or T1R2 and T1R3, but not T1R1 and T1R2 [22,23], and it has recently been shown that these distinct combinations of T1Rs bind to different sets of compounds, corresponding to sweet and umami substances [23-25]: in mouse, T1R2-T1R3 hetero(di)mers respond to sugars and sweeteners, whereas T1R1-T1R3 hetero(di)mers are activated by many L-amino acids, including L-glutamate and L-arginine, both of which are umami-tasting to humans.
Neg (not) Gene_expression (coexpress) of T1R3 associated with glutamate
1) Confidence 0.53 Published 2003 Journal Genome Biol Section Body Doc Link PMC193622 Disease Relevance 0 Pain Relevance 0.10
Expression studies have revealed that taste cells either coexpress T1R1 and T1R3 or T1R2 and T1R3, but not T1R1 and T1R2 [22,23], and it has recently been shown that these distinct combinations of T1Rs bind to different sets of compounds, corresponding to sweet and umami substances [23-25]: in mouse, T1R2-T1R3 hetero(di)mers respond to sugars and sweeteners, whereas T1R1-T1R3 hetero(di)mers are activated by many L-amino acids, including L-glutamate and L-arginine, both of which are umami-tasting to humans.
Neg (not) Gene_expression (coexpress) of T1R3 associated with glutamate
2) Confidence 0.53 Published 2003 Journal Genome Biol Section Body Doc Link PMC193622 Disease Relevance 0 Pain Relevance 0.13
Thus T1R2 and T1R3 were coexpressed in circumvallate and foliate taste buds but not in fungiform papillae [6], while sweeteners elicited stronger responses in the CT than in the NG.
Neg (not) Gene_expression (coexpressed) of T1R3 in papillae
3) Confidence 0.50 Published 2003 Journal BMC Neurosci Section Body Doc Link PMC153500 Disease Relevance 0.06 Pain Relevance 0
In favor of a role of intestinal glucose sensing, it has recently been shown that the sweet-taste receptor subunit T1R3 and the taste G-protein gustducin are expressed in enteroendocrine cells and underlie intestinal sugar sensing and regulation of SGLT1 mRNA and protein (29).
Gene_expression (expressed) of sweet-taste receptor subunit T1R3 in enteroendocrine cells
4) Confidence 0.26 Published 2008 Journal Diabetes Section Body Doc Link PMC2551668 Disease Relevance 0.08 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox