INT17349

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Context Info
Confidence 0.59
First Reported 1984
Last Reported 2011
Negated 0
Speculated 5
Reported most in Abstract
Documents 41
Total Number 46
Disease Relevance 27.03
Pain Relevance 10.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Akr1b1) oxidoreductase activity (Akr1b1) nucleolus (Akr1b1)
nucleus (Akr1b1) cytoplasm (Akr1b1)
Anatomy Link Frequency
nerve 6
lenses 6
plasma 1
neuronal 1
ciliary 1
Akr1b1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neuropathic pain 4 99.96 Very High Very High Very High
diabetic neuropathy 205 99.80 Very High Very High Very High
Kinase C 3 99.80 Very High Very High Very High
lidocaine 3 99.80 Very High Very High Very High
aspirin 9 99.52 Very High Very High Very High
Pain 32 99.46 Very High Very High Very High
Paracetamol 7 99.38 Very High Very High Very High
carpal tunnel syndrome 10 99.36 Very High Very High Very High
Analgesic 5 99.20 Very High Very High Very High
cINOD 3 99.18 Very High Very High Very High
Disease Link Frequency Relevance Heat
Neuropathic Pain 45 99.96 Very High Very High Very High
Neuropathy 11 99.92 Very High Very High Very High
Diabetes Mellitus 182 99.86 Very High Very High Very High
Diabetic Neuropathy 194 99.80 Very High Very High Very High
Pressure And Volume Under Development 6 99.68 Very High Very High Very High
Disease 4 99.44 Very High Very High Very High
Carpal Tunnel Syndrome 10 99.36 Very High Very High Very High
Peripheral Neuropathy 26 99.34 Very High Very High Very High
Sensation Disorders 4 99.28 Very High Very High Very High
INFLAMMATION 12 99.06 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Inhibition of the aldose reductase enzyme was found to depend on the presence of both the benzoyl and acetic acid functionalities.
Negative_regulation (Inhibition) of aldose reductase
1) Confidence 0.59 Published 1995 Journal J Pharm Sci Section Abstract Doc Link 7714750 Disease Relevance 0.45 Pain Relevance 0.25
Treatments are supported by several investigations in diabetic patients: aldose reductase inhibition, prevention of protein glycation, improvement of nerve and administration of neurotrophic factors.
Spec (investigations) Negative_regulation (inhibition) of aldose reductase in nerve associated with diabetes mellitus
2) Confidence 0.57 Published 2003 Journal Prz. Lek. Section Abstract Doc Link 14575019 Disease Relevance 1.08 Pain Relevance 0.49
This technique provides an effective method of screening potential inhibitors of aldose reductase under conditions that more closely approximate in vivo conditions than do earlier methods.
Negative_regulation (inhibitors) of aldose reductase
3) Confidence 0.57 Published 1986 Journal Science Section Abstract Doc Link 3088727 Disease Relevance 0.08 Pain Relevance 0.14
Carbon-13 nuclear magnetic resonance spectroscopy has been used in the study of glucose metabolism, specifically aldose reductase inhibition, in intact rabbit lenses maintained in organ culture.
Negative_regulation (inhibition) of aldose reductase in lenses
4) Confidence 0.57 Published 1986 Journal Science Section Abstract Doc Link 3088727 Disease Relevance 0.06 Pain Relevance 0.12
Study of aldose reductase inhibition in intact lenses by 13C nuclear magnetic resonance spectroscopy.
Negative_regulation (inhibition) of aldose reductase in lenses
5) Confidence 0.57 Published 1986 Journal Science Section Title Doc Link 3088727 Disease Relevance 0.07 Pain Relevance 0.12
Results of this work with various inhibitors of aldose reductase are discussed in terms of lens metabolism and implications regarding diabetic complications such as cataract formation.
Negative_regulation (inhibitors) of aldose reductase in lens associated with diabetes complications and cataract
6) Confidence 0.57 Published 1986 Journal Science Section Abstract Doc Link 3088727 Disease Relevance 0.29 Pain Relevance 0.14
Measurement of erythrocyte sorbitol concentrations demonstrated very significant inhibition of aldose reductase activity with sorbinil treatment, but no concomitant improvement in either peripheral or autonomic nerve function was observed.
Negative_regulation (inhibition) of aldose reductase in nerve
7) Confidence 0.57 Published 1987 Journal Diabetes Section Abstract Doc Link 3111914 Disease Relevance 0.24 Pain Relevance 0.13
Prevention of sensory disorders in diabetic Sprague-Dawley rats by aldose reductase inhibition or treatment with ciliary neurotrophic factor.
Negative_regulation (inhibition) of aldose reductase in ciliary associated with diabetes mellitus and sensation disorders
8) Confidence 0.54 Published 2004 Journal Diabetologia Section Title Doc Link 15298349 Disease Relevance 0.94 Pain Relevance 0.45
It has been demonstrated that 13C NMR spectroscopy provides an effective method of screening potential inhibitors of aldose reductase.
Negative_regulation (inhibitors) of aldose reductase
9) Confidence 0.53 Published 1987 Journal Exp. Eye Res. Section Abstract Doc Link 3115803 Disease Relevance 0.13 Pain Relevance 0.19
Tactile allodynia and formalin hyperalgesia in streptozotocin-diabetic rats: effects of insulin, aldose reductase inhibition and lidocaine.
Negative_regulation (inhibition) of aldose reductase associated with brush evoked pain, hyperalgesia, diabetes mellitus and lidocaine
10) Confidence 0.51 Published 1996 Journal Pain Section Title Doc Link 9121817 Disease Relevance 1.76 Pain Relevance 1.12
A new approach to the treatment of these and other late complications of diabetes may be offered by recently developed drugs, such as sorbinil, that inhibit the enzyme aldose reductase.
Negative_regulation (inhibit) of aldose reductase associated with diabetes mellitus
11) Confidence 0.51 Published 1986 Journal Drugs Section Abstract Doc Link 3098544 Disease Relevance 0.97 Pain Relevance 0.12
In various animal models of late complications of diabetes sorbinil and other aldose reductase inhibitors have been shown to reverse some of the biochemical and physiological changes believed to underlie these complications.
Negative_regulation (reverse) of aldose reductase associated with diabetes mellitus
12) Confidence 0.42 Published 1986 Journal Drugs Section Abstract Doc Link 3098544 Disease Relevance 0.97 Pain Relevance 0.11
These include vasodilators, protein kinase C beta inhibition, antioxidants, and novel aldose reductase inhibitors.
Negative_regulation (inhibitors) of aldose reductase associated with kinase c
13) Confidence 0.42 Published 2003 Journal Curr. Diab. Rep. Section Abstract Doc Link 14611741 Disease Relevance 0.41 Pain Relevance 0.68
A number of diabetic patients with diabetic neuropathy were treated with epalrestat, an aldose reductase inhibitor, since this drug was launched into the market in Japan.
Negative_regulation (inhibitor) of aldose reductase associated with diabetes mellitus and diabetic neuropathy
14) Confidence 0.42 Published 1996 Journal J. Diabetes Complicat. Section Abstract Doc Link 8807467 Disease Relevance 0.81 Pain Relevance 0.28
Clinical investigation of epalrestat, an aldose reductase inhibitor, on diabetic neuropathy in Japan: multicenter study.
Negative_regulation (inhibitor) of aldose reductase associated with pain and diabetic neuropathy
15) Confidence 0.42 Published 1996 Journal J. Diabetes Complicat. Section Title Doc Link 8807467 Disease Relevance 0.87 Pain Relevance 0.43
Furthermore, it is important for diabetics to be diagnosed and treated earlier to prevent progression to severe neuropathic complications by means of optimal glycemic control and use of some chemicals such as aldose reductase inhibitor, and to develop this study to evaluate the efficacy of treatments.
Negative_regulation (inhibitor) of aldose reductase associated with diabetes mellitus and neuropathic pain
16) Confidence 0.42 Published 2001 Journal Diabetes Res. Clin. Pract. Section Abstract Doc Link 11532329 Disease Relevance 0.97 Pain Relevance 0.24
Tolrestat, an aldose reductase inhibitor, was associated with good clinical response of symptoms due to peripheral neuropathy and thoracic polyradiculopathy.
Negative_regulation (inhibitor) of aldose reductase in thoracic associated with polyradiculopathy and peripheral neuropathy
17) Confidence 0.42 Published 1994 Journal Ir Med J Section Abstract Doc Link 7960657 Disease Relevance 0.92 Pain Relevance 0.21
For this condition, several promising disease-modifying drugs--including inhibitors of the aldose reductase and protein kinase C metabolic pathways--are currently in phase III development.
Negative_regulation (inhibitors) of aldose reductase associated with kinase c and disease
18) Confidence 0.42 Published 2005 Journal Current diabetes reviews Section Abstract Doc Link 18220603 Disease Relevance 1.18 Pain Relevance 0.38
The effects of the aldose-reductase inhibitor, tolrestat, on chronic symptomatic diabetic sensorimotor neuropathy were studied during a placebo-controlled, randomised, 52-week multicentre trial.
Negative_regulation (inhibitor) of aldose-reductase associated with diabetes mellitus and neuropathic pain
19) Confidence 0.42 Published 1990 Journal Diabetologia Section Abstract Doc Link 2119323 Disease Relevance 0.27 Pain Relevance 0.16
A multicentre trial of the aldose-reductase inhibitor, tolrestat, in patients with symptomatic diabetic neuropathy.
Negative_regulation (inhibitor) of aldose-reductase associated with pain and diabetic neuropathy
20) Confidence 0.42 Published 1990 Journal Diabetologia Section Title Doc Link 2119323 Disease Relevance 0.29 Pain Relevance 0.30

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