INT1735

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Context Info
Confidence 0.75
First Reported 1979
Last Reported 2011
Negated 4
Speculated 5
Reported most in Body
Documents 199
Total Number 205
Disease Relevance 257.87
Pain Relevance 11.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (HSD11B1) oxidoreductase activity (HSD11B1) endoplasmic reticulum (HSD11B1)
Anatomy Link Frequency
plasma 18
blood 7
liver 4
Heart 4
lymphatic system 2
HSD11B1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Serotonin 16 99.92 Very High Very High Very High
rheumatoid arthritis 460 99.80 Very High Very High Very High
agonist 56 99.72 Very High Very High Very High
Angina 261 99.34 Very High Very High Very High
spinal inflammation 15 99.00 Very High Very High Very High
adenocard 12 98.52 Very High Very High Very High
Chronic pancreatitis 55 97.48 Very High Very High Very High
alcohol 136 97.40 Very High Very High Very High
beta blocker 14 97.20 Very High Very High Very High
Inflammation 397 96.72 Very High Very High Very High
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 20308 100.00 Very High Very High Very High
Diabetes Mellitus 1440 100.00 Very High Very High Very High
Hypertension 424 100.00 Very High Very High Very High
Insulin Resistance 261 100.00 Very High Very High Very High
Sickle Cell Anemia 176 100.00 Very High Very High Very High
Hypertriglyceridemia 143 100.00 Very High Very High Very High
Metabolic Disorder 71 100.00 Very High Very High Very High
Hypolipidemia 31 100.00 Very High Very High Very High
Alpha-1-antitrypsin Deficiency 24 100.00 Very High Very High Very High
Dyslipidemia /

Combined Dyslipidemia

528 99.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Two common mutants of the CETP gene produce a CETP deficiency and resultant antiatherogenic lipoprotein pattern (i.e. hyper-HDL-cholesterolemia and hypo-LDL-cholesterolemia), and the frequency of the mutant allele is more than 1 in 10 subjects in Japan.
Gene_expression (produce) of HDL associated with disorder of lipid metabolism
1) Confidence 0.75 Published 1995 Journal Rinsho Byori Section Abstract Doc Link 7739114 Disease Relevance 1.38 Pain Relevance 0.07
We determined anthropometric data [body mass index and waist circumference (cut off score: BMI > 30, waist cut off score 102 cm)], systolic and diastolic blood pressure, 24 hours ECG, saliva cortisol and alpha-amylase levels, levels of serum low-density lipoprotein (LDL), serum high-density lipoprotein (HDL), cholesterol, glycosylated hemoglobin, triglycerides, serum dehydroepiandrosterone sulfate (DHEA-S), fibrinogen, CRP, and serum creatinin.
Gene_expression (levels) of HDL in saliva associated with obesity and disorder of lipid metabolism
2) Confidence 0.75 Published 2010 Journal BMC Public Health Section Body Doc Link PMC2881886 Disease Relevance 0.49 Pain Relevance 0.04
Correlations of high-density lipoprotein cholesterol (HDL-C), expressed in either absolute or relative terms, with a series of coronary risk factors and other variables were examined in the Israeli Ischemic Heart Disease Study sample.
Gene_expression (expressed) of HDL in Heart associated with coronary artery disease and disorder of lipid metabolism
3) Confidence 0.75 Published 1986 Journal Prev Med Section Abstract Doc Link 3797389 Disease Relevance 1.15 Pain Relevance 0.05
AC = (Total Cholesterol - HDL)/HDL
Gene_expression (/) of HDL associated with disorder of lipid metabolism
4) Confidence 0.65 Published 2007 Journal Lipids Health Dis Section Body Doc Link PMC1779269 Disease Relevance 0.68 Pain Relevance 0.04
Furthermore, other cardiovascular risk factors improved during rimonabant treatment, including increased HDL-C and adiponectin, and reduced TG, LDL:HDL and total:HDL-C ratios, and leptin and C-reactive protein levels.
Gene_expression (levels) of HDL associated with disorder of lipid metabolism
5) Confidence 0.65 Published 2007 Journal Core Evidence Section Body Doc Link PMC3012438 Disease Relevance 1.60 Pain Relevance 0
The adenosine triphosphate-binding cassette transporter A1 (ABCA1) plays a key role in HDL metabolism.
Gene_expression (metabolism) of HDL associated with adenocard and disorder of lipid metabolism
6) Confidence 0.65 Published 2009 Journal Metab. Clin. Exp. Section Abstract Doc Link 19059534 Disease Relevance 0.91 Pain Relevance 0.09
Ezetimibe therapy did reduce the LDL-C further, with an average reduction of 19.2%, with an accompanying reduction of HDL-C of 2.8 mg/dL (6.5%).
Gene_expression (reduce) of HDL associated with disorder of lipid metabolism
7) Confidence 0.65 Published 2010 Journal Clinical Medicine Insights. Cardiology Section Body Doc Link PMC2978935 Disease Relevance 0.52 Pain Relevance 0
Systolic blood pressure (p=0.04), triglyceride to HDL cholesterol ratio (p=0.002), and LDL cholesterol (p=0.03) were found significantly higher in AS pts than in controls; on the contrary, HDL cholesterol was pointed out as significantly lower (p<0.001).
Gene_expression (found) of HDL in blood associated with spinal inflammation and disorder of lipid metabolism
8) Confidence 0.65 Published 2007 Journal Clin. Rheumatol. Section Abstract Doc Link 16933103 Disease Relevance 1.80 Pain Relevance 0.65
This may be due to classic risk factors such as high triglyceride (TG), high total cholesterol (TC), and low levels of high density lipoprotein cholesterol (HDL-C).
Gene_expression (levels) of HDL associated with disorder of lipid metabolism
9) Confidence 0.65 Published 2000 Journal Atherosclerosis Section Abstract Doc Link 10856533 Disease Relevance 1.15 Pain Relevance 0.50
We measured following biochemical parameters: total protein, albumin, total cholesterol, HDL cholesterol, LDL cholesterol, triglycerides, glycemia, and C-reactive protein.
Gene_expression (cholesterol) of HDL
10) Confidence 0.65 Published 2010 Journal Spinal Cord Section Body Doc Link 19546874 Disease Relevance 0 Pain Relevance 0
The results of these studies will likely increase the use of higher statin doses and also combination therapy to achieve greater LDL-C reductions and improvements in elevated triglycerides, low HDL-C, and LDL-C distribution.


Gene_expression (distribution) of HDL associated with hypertriglyceridemia and disorder of lipid metabolism
11) Confidence 0.65 Published 2005 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993967 Disease Relevance 0.59 Pain Relevance 0.04
Among males, there was interaction between COX-2 T8473C and alcohol in relation to total cholesterol, non-HDL cholesterol and LDL levels (p for interaction: 0.003, 0.007 and 0.01, respectively), such that variant allele carriers with low alcohol intake had the lowest lipid levels.
Gene_expression (cholesterol) of HDL
12) Confidence 0.65 Published 2010 Journal Atherosclerosis Section Body Doc Link 19748095 Disease Relevance 0 Pain Relevance 0
Pain intensity, assessed using the visual analogue scale (VAS) on a scale from 0-10, and the following biochemical parameters were measured during the initial patient workups: blood serum total protein, glucose, total cholesterol, HDL cholesterol, LDL cholesterol, atherosclerotic indexes, triacylglyceroles, apolipoprotein A, apolipoprotein B, albumin, alpha1 globulin, alpha2 globulin, beta globulin and gamma globulin.
Gene_expression (cholesterol) of HDL in blood
13) Confidence 0.65 Published 2009 Journal Neuro Endocrinol. Lett. Section Body Doc Link 20035266 Disease Relevance 0.08 Pain Relevance 0
The LPLSer(447)X variant is associated with decreased levels of plasma TGs and increased HDL cholesterol concentrations compared with wild-type LPL.
Gene_expression (levels) of HDL in plasma associated with disorder of lipid metabolism
14) Confidence 0.65 Published 2009 Journal Curr. Opin. Mol. Ther. Section Abstract Doc Link 20072945 Disease Relevance 0.60 Pain Relevance 0.09
AC = (Total Cholesterol - HDL)/HDL
Gene_expression (/) of HDL associated with disorder of lipid metabolism
15) Confidence 0.65 Published 2007 Journal Lipids Health Dis Section Body Doc Link PMC1779269 Disease Relevance 0.68 Pain Relevance 0.04
In diabetic women, a 1 SD increase of TC, LDL-C, non-HDL-C, TG, TC/HDL-C and TG/HDL-C resulted in a significant risk of incident CVD in age adjusted model, however; a 1 SD increase in HDL-C decreased the risk of CVD ?
Gene_expression (/) of HDL associated with hypertriglyceridemia, cardiovascular disease, diabetes mellitus and disorder of lipid metabolism
16) Confidence 0.65 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2835707 Disease Relevance 3.87 Pain Relevance 0.03
In diabetic women, a 1 SD increase of TC, LDL-C, non-HDL-C, TG, TC/HDL-C and TG/HDL-C resulted in a significant risk of incident CVD in age adjusted model, however; a 1 SD increase in HDL-C decreased the risk of CVD ?
Gene_expression (/) of HDL associated with hypertriglyceridemia, cardiovascular disease, diabetes mellitus and disorder of lipid metabolism
17) Confidence 0.65 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2835707 Disease Relevance 3.87 Pain Relevance 0.03
Serum C, TG, Lp(a), apo E, apo A-I, apo B, HDL-C and RLP-C were measured in 652 patients who underwent diagnostic coronary angiography.
Gene_expression (measured) of HDL associated with disorder of lipid metabolism
18) Confidence 0.65 Published 1998 Journal Atherosclerosis Section Abstract Doc Link 9712343 Disease Relevance 0.85 Pain Relevance 0.08
The associations between IGFBP-1 levels and HDL cholesterol, WHR, and BMI remained significant after adjustment for fasting insulin levels.
Gene_expression (levels) of HDL associated with obesity and disorder of lipid metabolism
19) Confidence 0.65 Published 1998 Journal Arterioscler. Thromb. Vasc. Biol. Section Abstract Doc Link 9484994 Disease Relevance 1.13 Pain Relevance 0.07
They are presented before and after adjustment for clusters of confounding variables that are markers of different mechanisms: insulin resistance (body mass index, triglyceride, and HDL cholesterol), inflammation (fibrinogen and C-reactive protein), and endothelial cell damage (von Willebrand factor).
Gene_expression (resistance) of HDL in endothelial cell
20) Confidence 0.65 Published 1996 Journal Circulation Section Body Doc Link 8901651 Disease Relevance 0.08 Pain Relevance 0

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