INT173504

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Context Info
Confidence 0.47
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 16
Total Number 16
Disease Relevance 7.20
Pain Relevance 2.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ighg1)
Anatomy Link Frequency
PSP 4
B cell 2
eosinophils 2
goblet cell 2
Ighg1 (Mus musculus)
Pain Link Frequency Relevance Heat
Arthritis 120 99.26 Very High Very High Very High
cytokine 174 99.14 Very High Very High Very High
Inflammation 191 98.72 Very High Very High Very High
chemokine 25 91.56 High High
Multiple sclerosis 164 91.48 High High
Glutamate receptor 1 83.12 Quite High
Glutamate 5 81.12 Quite High
cva 5 77.28 Quite High
alcohol 6 73.12 Quite High
Potency 4 70.80 Quite High
Disease Link Frequency Relevance Heat
Hypersensitivity 191 99.78 Very High Very High Very High
Aspergillus Infection 44 99.28 Very High Very High Very High
Arthritis 142 99.26 Very High Very High Very High
INFLAMMATION 192 98.72 Very High Very High Very High
Adhesions 17 98.60 Very High Very High Very High
Multiple Sclerosis 42 97.76 Very High Very High Very High
Targeted Disruption 19 96.88 Very High Very High Very High
Hyperplasia 4 93.00 High High
Demyelinating Disease 156 91.48 High High
Respiratory Disease 24 90.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, the organic chemicals in DEP, rather than the residual carbonaceous nuclei of DEP, exaggerate allergic airway inflammation with goblet cell proliferation, enhance the Th2 responses, and increase the production of antigen-specific IgG1, whereas whole DEP cause the most remarkable aggravation.
Positive_regulation (increase) of Gene_expression (production) of IgG1 in goblet cell associated with inflammation and hypersensitivity
1) Confidence 0.47 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2127221 Disease Relevance 0.56 Pain Relevance 0.17
Similarly to our previous findings [12,17], Af sensitization resulted in markedly increased serum IgE, IgG1 and IgG2a levels.
Positive_regulation (increased) of Gene_expression (levels) of IgG1 associated with aspergillus infection
2) Confidence 0.40 Published 2003 Journal Respir Res Section Body Doc Link PMC314399 Disease Relevance 1.27 Pain Relevance 0.04
g OVA, regardless of PSP dose, induced significantly higher IgE levels than the other OVA doses, and higher IgG1 levels than 100 ?
Positive_regulation (higher) of Gene_expression (levels) of IgG1 in PSP
3) Confidence 0.38 Published 2005 Journal BMC Immunol Section Body Doc Link PMC1182367 Disease Relevance 0.18 Pain Relevance 0.03
g OVA, regardless of PSP dose, induced significantly higher IgE levels than the other OVA doses, and higher IgG1 levels than 100 ?
Positive_regulation (induced) of Gene_expression (levels) of IgG1 in PSP
4) Confidence 0.38 Published 2005 Journal BMC Immunol Section Body Doc Link PMC1182367 Disease Relevance 0.18 Pain Relevance 0.03
For example, DnOP produced a concentration-dependent increase in production of IgG1 but not IgE (Larsen et al. 2002).
Positive_regulation (increase) of Gene_expression (production) of IgG1
5) Confidence 0.37 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2453150 Disease Relevance 0 Pain Relevance 0.16
Stimulation of the TH2 pathway, which is predominant in type I allergies, involves increased production of IgE and IgG1 antibodies, whereas stimulation of the TH1 response, predominant in type IV allergies, involves IgG2a antibodies (Larsen et al. 2001a).
Positive_regulation (increased) of Gene_expression (production) of IgG1 associated with hypersensitivity
6) Confidence 0.37 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2453150 Disease Relevance 0.20 Pain Relevance 0.06
production after IM vaccination is consistent with the heightened Th1-like response indicated by the reduced IgG1/IgG2a ratio in the IM groups, since IFN-?
Positive_regulation (since) of Gene_expression (ratio) of IgG1
7) Confidence 0.35 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2651574 Disease Relevance 0.16 Pain Relevance 0
Arthritis can be induced in recipient mice by transfer of polyclonal IgG1 or combinations of at least two different monoclonal IgG1 antibodies against G6PI [69].
Positive_regulation (transfer) of Gene_expression (transfer) of IgG1 associated with arthritis
8) Confidence 0.35 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064898 Disease Relevance 0.99 Pain Relevance 0.35
Exposure to DEP-OC significantly increased the production of OVA-specific IgG1 as compared with vehicle exposed alone (Fig. 3).
Positive_regulation (increased) of Gene_expression (production) of IgG1
9) Confidence 0.32 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2127221 Disease Relevance 0.29 Pain Relevance 0.14
Furthermore, 14 nm nano particles had obvious adjuvant activity for the antigen-specific production of IgG1 and IgE.
Positive_regulation (had) of Gene_expression (production) of IgG1
10) Confidence 0.31 Published 2005 Journal Respir Res Section Body Doc Link PMC1242256 Disease Relevance 0.90 Pain Relevance 0.34
Also, these Th2 cytokines are implicated in the pathogenesis of allergic reactions via their roles in mediating IgG1 and IgE production, and in differentiation, vascular adhesion, recruitment, activation, and survival of eosinophils.
Positive_regulation (mediating) of Gene_expression (production) of IgG1 in eosinophils associated with hypersensitivity, adhesions and cytokine
11) Confidence 0.31 Published 2005 Journal Respir Res Section Body Doc Link PMC1242256 Disease Relevance 0.91 Pain Relevance 0.27
In the same study, total level of type II collagen specific IgG and the levels of IgG1 and IgG2a were measured in order to investigate the effects of IFN-?
Positive_regulation (level) of Gene_expression (levels) of IgG1
12) Confidence 0.29 Published 2002 Journal Arthritis Res Section Body Doc Link PMC153843 Disease Relevance 0.67 Pain Relevance 0.10
While IgG1 antibodies are present in Th1 and Th2 immunity, B cell isotype switching to IgG2a requires IFN-?
Positive_regulation (present) of Gene_expression (antibodies) of IgG1 in B cell
13) Confidence 0.28 Published 2006 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1459156 Disease Relevance 0 Pain Relevance 0.03
g/mL DiNP following a single booster of ovalbumin produced non–concentration-dependent increased levels of IgG1 and IgE; however, after two boosters, a concentration-dependent adjuvancy in IgG1, but no adjuvancy in IgE, was observed (Larsen et al. 2002).
Positive_regulation (increased) of Gene_expression (levels) of IgG1
14) Confidence 0.27 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2453150 Disease Relevance 0 Pain Relevance 0.16
For the cytophilic IgG1 and IgG3, there was a marked increase in three to four year old children (Figure 2).
Positive_regulation (increase) of Gene_expression (cytophilic) of IgG1
15) Confidence 0.16 Published 2005 Journal Malar J Section Body Doc Link PMC1262760 Disease Relevance 0.08 Pain Relevance 0
In vitro testing documents a phenotypic shift from Th1 to Th2 expression during estrogen use in EAE models.48 The Th2- dominant expression results from altered cytokine production, increased IL-10 levels,49 and increased IgG1 antibody production specific for the autoantigen, MBP.50 Additional studies in estrogen receptor knockout mice have shown that protective effects of estradiol and estriol are dependent on estrogen receptor ?
Positive_regulation (increased) of Gene_expression (production) of IgG1 associated with targeted disruption, multiple sclerosis and cytokine
16) Confidence 0.12 Published 2010 Journal Drug Design, Development and Therapy Section Body Doc Link PMC2998807 Disease Relevance 0.83 Pain Relevance 0.47

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