INT173505

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Context Info
Confidence 0.57
First Reported 2002
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 63
Total Number 63
Disease Relevance 45.32
Pain Relevance 13.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Hand2) nucleus (Hand2) DNA binding (Hand2)
protein complex (Hand2) transcription factor binding (Hand2)
Anatomy Link Frequency
Th2 cells 9
T cells 6
lymphocytes 4
eosinophils 4
mast cells 4
Hand2 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 1640 100.00 Very High Very High Very High
Inflammation 1915 99.60 Very High Very High Very High
Central nervous system 238 99.14 Very High Very High Very High
antagonist 325 98.92 Very High Very High Very High
fibrosis 43 98.68 Very High Very High Very High
rheumatoid arthritis 164 96.32 Very High Very High Very High
psoriasis 14 96.26 Very High Very High Very High
chemokine 517 95.98 Very High Very High Very High
Inflammatory response 138 94.76 High High
aspirin 4 93.80 High High
Disease Link Frequency Relevance Heat
Immunization 115 100.00 Very High Very High Very High
Hypersensitivity 391 99.84 Very High Very High Very High
Sprains And Strains 249 99.82 Very High Very High Very High
INFLAMMATION 2038 99.60 Very High Very High Very High
Gastritis 115 99.38 Very High Very High Very High
Central Nervous System Disease 192 99.14 Very High Very High Very High
Asthma 2447 98.96 Very High Very High Very High
Targeted Disruption 246 98.88 Very High Very High Very High
Fibrosis 35 98.68 Very High Very High Very High
Colitis 123 98.64 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As oxazolone-induced colitis is a representative Th2 cell-mediated process, we compared Th1 and Th2 cytokine secretion by CD4+ T cell from CIIT-Tg mice and wild type littermates.
Localization (secretion) of Th2 in T cell associated with colitis and cytokine
1) Confidence 0.57 Published 2006 Journal Journal of Korean Medical Science Section Body Doc Link PMC2721999 Disease Relevance 0.68 Pain Relevance 0.16
In contrast, conditional deletion of SHIP-1 in T cells resulted in reduced Th2 responses to nitrophenylacetyl hapten conjugated to chicken ?
Localization (responses) of Th2 in T cells
2) Confidence 0.53 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2994819 Disease Relevance 0.53 Pain Relevance 0.12
As we expected, oxazolone-induced colonic inflammation was aggravated in CIITA-Tg mice (Fig. 3, 4), confirming that the CIITA expression in CD4+ T cells tends to bias CD4+ T cell response into Th2.
Localization (response) of Th2 in T cell associated with inflammation
3) Confidence 0.53 Published 2006 Journal Journal of Korean Medical Science Section Body Doc Link PMC2721999 Disease Relevance 1.24 Pain Relevance 0.22
However, the data shown by Otten et al. and our group were in sharp contrast with the prediction, in that the two independent CIITA-Tg mice (ectopic expression of CIITA in all types of cells in the body and restricted expression of the molecule in mature T cells, respectively) rendered the transgenic CD4+ T cells to differentiate preferentially into IL-4 secreting Th2-type cells in vitro (13, 14).
Localization (secreting) of Th2-type in mature T cells associated with targeted disruption
4) Confidence 0.50 Published 2006 Journal Journal of Korean Medical Science Section Body Doc Link PMC2721999 Disease Relevance 0.74 Pain Relevance 0
Therefore, in the context of chemical-induced asthma, it is not correct to state that a certain mouse strain is more Th2-biased than Th1-biased.
Localization (biased) of Th2 associated with asthma and sprains and strains
5) Confidence 0.46 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935354 Disease Relevance 1.42 Pain Relevance 0.03
Allergic diseases are characterized by elevated serum IgE, an inflammatory reaction with increased number of eosinophils, mast cells and an adaptative immune responses orchestrated by Th2-like CD4+ memory T cells secreting an array of cytokines such as IL-4, IL-5 and IL-13.
Localization (secreting) of Th2 in memory T cells associated with inflammation, hypersensitivity, disease and cytokine
6) Confidence 0.42 Published 2005 Journal Respir Res Section Body Doc Link PMC555575 Disease Relevance 0.66 Pain Relevance 0.10
C3H/HeN mice responded with both Th1- and Th2-type cytokine secretion, although apparently Th1-skewed due to low IL-4 and IL-10 levels, after both OVA or PSP treatments.
Localization (secretion) of Th2-type in PSP associated with cytokine
7) Confidence 0.42 Published 2005 Journal BMC Immunol Section Body Doc Link PMC1182367 Disease Relevance 0.28 Pain Relevance 0.28
an additional index of Th2 cytokine secretion, we measured IgE in BALF from mice in all groups.
Localization (secretion) of Th2 associated with cytokine
8) Confidence 0.37 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2276601 Disease Relevance 0.29 Pain Relevance 0.13
Notably, a profound reduction in Th2 polarization and the production of the effector Th2 cytokine, IL-13, was observed [6].
Localization (polarization) of Th2 associated with cytokine
9) Confidence 0.35 Published 2010 Journal Respir Res Section Body Doc Link PMC2914735 Disease Relevance 1.01 Pain Relevance 0.21
Reduction in IL-4 levels would likely suggest that subsequent Th0 to Th2 polarization of new effectors cells with each antigen challenge would be disrupted.
Localization (polarization) of Th2
10) Confidence 0.35 Published 2010 Journal Respir Res Section Body Doc Link PMC2914735 Disease Relevance 0.21 Pain Relevance 0.27
The first consideration suggests, that the decreased CCL2 level likely relate to a decreased TH2 lymphocyte activity, as CCL2 induces TH2 polarization.
Localization (polarization) of TH2 in lymphocyte
11) Confidence 0.35 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 0.62 Pain Relevance 0.29
Thus, the functional involvement of CCL chemokines during EAE is not only restricted to a well orchestrated recruitment of dendritic cells, monocytes, macrophages, T effector and regulatory cells into the CNS, but also includes a temporal and spatial regulation of TH1 (CCL3, CCL5) or TH2 (CCL2, CCL22) polarization, and monocyte, macrophage and microglial activation (CCL1, CCL2, CCL7, CCL8).
Localization (regulation) of TH2 in macrophages associated with chemokine, multiple sclerosis and central nervous system
12) Confidence 0.35 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 1.08 Pain Relevance 0.23
CD4+ T cells isolated from the spleen and CLNs also significantly secreted Th2 cytokines after ex vivo stimulation of PspA peptides, than compared to naïve mice.
Localization (secreted) of Th2 in spleen associated with cytokine
13) Confidence 0.35 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2828482 Disease Relevance 1.05 Pain Relevance 0.12
IL-5 secretion from Th2 cells.
Localization (secretion) of Th2 in Th2 cells
14) Confidence 0.32 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2276601 Disease Relevance 1.07 Pain Relevance 0.15
The isotype profiles were similar to the pre-challenge data, maintaining the observed skewed responses toward Th2 for the MN immunization and Th1 for the IM immunization (Figure 5C, D).


Localization (immunization) of Th2 associated with immunization
15) Confidence 0.31 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2651574 Disease Relevance 0.50 Pain Relevance 0.09
Mast cells and eosinophils synthesize, store, and release a similar profile of Th2 cytokines.
Localization (release) of Th2 in eosinophils associated with cytokine
16) Confidence 0.31 Published 2008 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2868889 Disease Relevance 0.97 Pain Relevance 0.11
Similar CLN Th2 cells secreted IL-4 in response to peptides 19 and 20 whereas heightened IL-5 secretion was noted in response to peptides 19 to 22 as well as 29 and 35, than compared to naive mice.
Localization (secreted) of Th2 in Th2 cells
17) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2828482 Disease Relevance 0.60 Pain Relevance 0.03
By secreting these three cytokines, TH2 cells exert influence on asthma pathogenesis on the level of T cells, B cells, and structural cells.
Localization (secreting) of TH2 in structural cells associated with asthma and cytokine
18) Confidence 0.29 Published 2010 Journal Journal of Allergy Section Body Doc Link PMC2957587 Disease Relevance 0.80 Pain Relevance 0.18
IL-4 is the hallmark cytokine of the Th2 phenotype, but IL-10 is secreted by Th2 cells and a number of the recently identified Treg populations that play a crucial role in limiting inflammation [25,26].
Localization (secreted) of Th2 in Th2 cells associated with inflammation and cytokine
19) Confidence 0.29 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2584092 Disease Relevance 0.15 Pain Relevance 0.14
Th2-type responses are characterized by increases in the levels of interleukin (IL)-4 and other Th2 cytokines (IL-5, IL-9, IL-13, and IL-21), activation and expansion of CD4+ Th2 cells, plasma cells secreting IgE, eosinophils, basophils, and mast cells, all of which can synthesize and release several types of Th2 cytokines [5].
Localization (secreting) of Th2 in basophils associated with cytokine
20) Confidence 0.27 Published 2008 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2868889 Disease Relevance 0.69 Pain Relevance 0.13

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