INT173507

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Context Info
Confidence 0.26
First Reported 2002
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 12
Total Number 12
Disease Relevance 5.97
Pain Relevance 0.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
Th1 cells 2
IgG2a (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 238 92.28 High High
Arthritis 23 86.52 High High
Inflammation 150 79.64 Quite High
Inflammatory response 25 57.44 Quite High
rheumatoid arthritis 37 50.00 Quite Low
transdermal 7 50.00 Quite Low
antagonist 13 47.48 Quite Low
anesthesia 8 44.48 Quite Low
Neurotransmitter 5 24.48 Low Low
metalloproteinase 10 19.00 Low Low
Disease Link Frequency Relevance Heat
Candida Infection 137 100.00 Very High Very High Very High
Sprains And Strains 73 99.80 Very High Very High Very High
Aspergillus Infection 44 99.28 Very High Very High Very High
Immunization 93 98.44 Very High Very High Very High
Granuloma 21 95.08 Very High Very High Very High
Helminth Infection 117 93.60 High High
Necrosis 6 91.32 High High
Cancer 11 90.96 High High
Pressure And Volume Under Development 12 89.80 High High
Arthritis 27 86.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As shown in Figure 2, the response patterns for BALB/cA and NIH mice were similar to those shown in Figure 1, with increased IgE production in both strains, whereas IgG2a production was increased only in NIH mice.
Positive_regulation (increased) of Gene_expression (production) of IgG2a associated with sprains and strains
1) Confidence 0.26 Published 2005 Journal BMC Immunol Section Body Doc Link PMC1182367 Disease Relevance 0.31 Pain Relevance 0
Similarly to our previous findings [12,17], Af sensitization resulted in markedly increased serum IgE, IgG1 and IgG2a levels.
Positive_regulation (increased) of Gene_expression (levels) of IgG2a associated with aspergillus infection
2) Confidence 0.25 Published 2003 Journal Respir Res Section Body Doc Link PMC314399 Disease Relevance 1.27 Pain Relevance 0.04
production after IM vaccination is consistent with the heightened Th1-like response indicated by the reduced IgG1/IgG2a ratio in the IM groups, since IFN-?
Positive_regulation (since) of Gene_expression (ratio) of IgG2a
3) Confidence 0.25 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2651574 Disease Relevance 0.16 Pain Relevance 0
In the same study, total level of type II collagen specific IgG and the levels of IgG1 and IgG2a were measured in order to investigate the effects of IFN-?
Positive_regulation (level) of Gene_expression (levels) of IgG2a
4) Confidence 0.14 Published 2002 Journal Arthritis Res Section Body Doc Link PMC153843 Disease Relevance 0.67 Pain Relevance 0.10
In response to the photooxidized human grafts, there was no elevated human collagen-specific total IgG and IgG2a production, while a weak IgG1 response was observed in two of eight mice.
Neg (no) Positive_regulation (elevated) of Gene_expression (production) of IgG2a
5) Confidence 0.12 Published 2006 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1459156 Disease Relevance 0 Pain Relevance 0.08
Protective immunity in mice was associated with high titers of specific anti-Sm29 IgG1 and IgG2a and elevated production of IFN-?
Positive_regulation (elevated) of Gene_expression (production) of IgG2a
6) Confidence 0.12 Published 2008 Journal PLoS Neglected Tropical Diseases Section Abstract Doc Link PMC2553283 Disease Relevance 0.99 Pain Relevance 0
The levels of specific IgG1 and IgG2a increased at 15, 30 and 45 days after the first immunization (Table 1).
Positive_regulation (increased) of Gene_expression (levels) of IgG2a associated with immunization
7) Confidence 0.12 Published 2008 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2553283 Disease Relevance 0.45 Pain Relevance 0.03
In addition, one mouse exhibited high IgG2a production after twelve weeks.
Positive_regulation (high) of Gene_expression (production) of IgG2a
8) Confidence 0.12 Published 2006 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1459156 Disease Relevance 0 Pain Relevance 0.04
In the present study, CSBG plus OVA amplified the production of OVA-specific IgG2a as compared to OVA alone in vivo and CSBG activated DC to produce/release higher levels of OVA-stimulated IFN-?
Positive_regulation (stimulated) of Gene_expression (production) of IgG2a associated with candida infection
9) Confidence 0.11 Published 2009 Journal Respir Res Section Body Doc Link PMC2731726 Disease Relevance 1.16 Pain Relevance 0.08
Furthermore, IgG1/IgG2a ratio was reduced at days 30 and 45 that parallels with elevated anti-Sm29 IgG2a production.
Positive_regulation (elevated) of Gene_expression (production) of IgG2a
10) Confidence 0.10 Published 2008 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2553283 Disease Relevance 0.37 Pain Relevance 0.04
Purified IgG2a and FITC-IgG2a were obtained from Sigma (St.
Positive_regulation (Purified) of Gene_expression (obtained) of IgG2a
11) Confidence 0.04 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2987830 Disease Relevance 0.25 Pain Relevance 0
Th1 cells also induce the production of IgG2a opsonizing antibodies [62].
Positive_regulation (induce) of Gene_expression (production) of IgG2a in Th1 cells
12) Confidence 0.04 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2838227 Disease Relevance 0.34 Pain Relevance 0.24

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