INT173508

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Context Info
Confidence 0.55
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 7
Disease Relevance 5.08
Pain Relevance 0.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Fgfr1) nucleus (Fgfr1) kinase activity (Fgfr1)
cytoplasm (Fgfr1)
Anatomy Link Frequency
keratinocytes 3
hair 1
fibroblast 1
neutrophil 1
Fgfr1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory response 22 98.36 Very High Very High Very High
rheumatoid arthritis 39 90.56 High High
addiction 1 90.32 High High
Inflammation 124 89.96 High High
Arthritis 23 86.00 High High
psoriasis 4 70.72 Quite High
fibrosis 4 67.08 Quite High
antagonist 8 64.56 Quite High
cytokine 46 60.88 Quite High
member 8 8 56.24 Quite High
Disease Link Frequency Relevance Heat
Cancer 97 100.00 Very High Very High Very High
Necrosis 10 100.00 Very High Very High Very High
Skin Diseases 22 98.72 Very High Very High Very High
INFLAMMATION 132 98.36 Very High Very High Very High
Pigment Disorder 1 97.64 Very High Very High Very High
Congenital Anomalies 40 97.40 Very High Very High Very High
Chondrosarcoma 23 95.04 Very High Very High Very High
Skin Abnormalities 8 94.96 High High
Acanthosis 32 93.68 High High
Apoptosis 12 90.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Loss of FGFR1 and FGFR2 in keratinocytes causes hyperproliferation in vivo but not in vitro
Negative_regulation (Loss) of FGFR1 in keratinocytes
1) Confidence 0.55 Published 2010 Journal The Journal of Cell Biology Section Body Doc Link PMC2845079 Disease Relevance 1.06 Pain Relevance 0.03
Loss of FGFR1 and 2 in keratinocytes impairs hair regeneration
Negative_regulation (Loss) of FGFR1 in hair
2) Confidence 0.55 Published 2010 Journal The Journal of Cell Biology Section Body Doc Link PMC2845079 Disease Relevance 0.28 Pain Relevance 0.03
These results demonstrate that the loss of FGFR1 and FGFR2 in keratinocytes initiates an inflammatory response.
Negative_regulation (loss) of FGFR1 in keratinocytes associated with inflammatory response
3) Confidence 0.40 Published 2010 Journal The Journal of Cell Biology Section Body Doc Link PMC2845079 Disease Relevance 0.16 Pain Relevance 0.17
Generation and maintenance of mice lacking FGFR1 and/or FGFR2 in keratinocytes
Negative_regulation (lacking) of FGFR1 in keratinocytes
4) Confidence 0.40 Published 2010 Journal The Journal of Cell Biology Section Body Doc Link PMC2845079 Disease Relevance 0.76 Pain Relevance 0.15
This effect appears to be induced by the antiangiogenic effects of SU6668, which are mediated by the inhibition of the key angiogenic receptor tyrosine kinases Flk-1/KDR, PDGFRbeta and FGFR1.
Negative_regulation (inhibition) of FGFR1
5) Confidence 0.29 Published 2007 Journal BMC Cancer Section Abstract Doc Link PMC1832206 Disease Relevance 0.97 Pain Relevance 0
has been shown to downregulate basic fibroblast growth factor at mRNA and protein levels [20].
Negative_regulation (downregulate) of basic fibroblast growth factor in fibroblast
6) Confidence 0.06 Published 2002 Journal Arthritis Res Section Body Doc Link PMC153843 Disease Relevance 0.92 Pain Relevance 0.20
Thalidomide shows immunomodulatory activity such as suppression of tumour necrosis factor-alpha, basic fibroblast growth factor and neutrophil chemotaxis.
Negative_regulation (suppression) of basic fibroblast growth factor in neutrophil associated with necrosis and cancer
7) Confidence 0.01 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC1857704 Disease Relevance 0.93 Pain Relevance 0.08

General Comments

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