INT173512

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Context Info
Confidence 0.44
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 12
Disease Relevance 8.66
Pain Relevance 1.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeleton (Alms1) cilium (Alms1) molecular_function (Alms1)
lipid metabolic process (Alms1) cytoplasm (Alms1)
Anatomy Link Frequency
leukocyte 4
microglial cells 3
blood 2
endothelial cells 2
perivascular macrophages 1
Alms1 (Mus musculus)
Pain Link Frequency Relevance Heat
Central nervous system 227 100.00 Very High Very High Very High
Inflammation 144 100.00 Very High Very High Very High
Multiple sclerosis 112 86.96 High High
tolerance 3 81.20 Quite High
rheumatoid arthritis 37 75.92 Quite High
Demyelination 3 75.68 Quite High
antagonist 7 68.68 Quite High
cytokine 37 68.00 Quite High
Arthritis 19 66.56 Quite High
Analgesic 2 55.04 Quite High
Disease Link Frequency Relevance Heat
Multiple Sclerosis 266 100.00 Very High Very High Very High
INFLAMMATION 142 100.00 Very High Very High Very High
Adhesions 100 100.00 Very High Very High Very High
Lymphatic System Cancer 2 100.00 Very High Very High Very High
Disease 111 99.98 Very High Very High Very High
Convulsion 55 99.72 Very High Very High Very High
Epilepsy 67 99.50 Very High Very High Very High
Neuromyelitis Optica 215 98.18 Very High Very High Very High
Vasculitis 5 91.20 High High
Autoimmune Disease 25 88.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Identification of novel disease-causing ALMS1 mutation
Positive_regulation (causing) of Gene_expression (mutation) of ALMS1 associated with disease
1) Confidence 0.44 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC2266715 Disease Relevance 0.10 Pain Relevance 0
NPs for drug delivery: Need of surfactants for BBB transport
Positive_regulation (surfactants) of Gene_expression (transport) of BBB
2) Confidence 0.11 Published 2010 Journal Part Fibre Toxicol Section Body Doc Link PMC2847536 Disease Relevance 0 Pain Relevance 0.06
-cat is required for BBB maturation and function in vivo and that transcriptional activation of ?
Positive_regulation (required) of Gene_expression (maturation) of BBB
3) Confidence 0.10 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2575783 Disease Relevance 0 Pain Relevance 0
-cat is required for BBB maturation and function in vivo and that transcriptional activation of ?
Positive_regulation (activation) of Gene_expression (maturation) of BBB
4) Confidence 0.10 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2575783 Disease Relevance 0 Pain Relevance 0
Thus, increased expression of MHC class I and II molecules on microglial cells and perivascular macrophages, which are known characteristic immunopathological changes observed in the CNS parenchyma during EAE, are similarly observed in the BBB-deficient areas of the CVOs [22].
Positive_regulation (increased) of Gene_expression (expression) of BBB in microglial cells associated with multiple sclerosis and central nervous system
5) Confidence 0.09 Published 2005 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC1262737 Disease Relevance 0.60 Pain Relevance 0.12
These observations indicate that inflammatory cell recruitment into the CVOs is not necessarily mediated by the same mechanisms as those regulating leukocyte recruitment across the inflamed BBB, which during EAE was shown to be mainly dependent on ?
Positive_regulation (dependent) of Gene_expression (shown) of BBB in leukocyte associated with multiple sclerosis and inflammation
6) Confidence 0.09 Published 2005 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC1262737 Disease Relevance 0.99 Pain Relevance 0.34
These observations indicate that inflammatory cell recruitment into the CVOs is not necessarily mediated by the same mechanisms as those regulating leukocyte recruitment across the inflamed BBB, which during EAE was shown to be mainly dependent on ?
Positive_regulation (during) of Gene_expression (shown) of BBB in leukocyte associated with multiple sclerosis and inflammation
7) Confidence 0.09 Published 2005 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC1262737 Disease Relevance 0.98 Pain Relevance 0.31
These activated T cells increase the expression of adhesion molecules such as intercellular adhesion molecule (ICAM)-1 and vascular cell adhesion molecule (VCAM)-1 on blood–brain barrier (BBB) endothelial cells.
Positive_regulation (increase) of Gene_expression (expression) of BBB in endothelial cells associated with adhesions
8) Confidence 0.06 Published 2002 Journal Arthritis Res Section Body Doc Link PMC153843 Disease Relevance 1.84 Pain Relevance 0.62
In support to the results obtained from animal models of epilepsy, it has been shown that BBB disruption in patients with cerebral lymphoma induces focal motor seizures [9].
Positive_regulation (induces) of Gene_expression (disruption) of BBB associated with epilepsy, convulsion and lymphatic system cancer
9) Confidence 0.04 Published 2010 Journal BMC Neurol Section Body Doc Link PMC2954970 Disease Relevance 1.78 Pain Relevance 0.16
Thus, increased expression of MHC class I and II molecules on microglial cells and perivascular macrophages, which are known characteristic immunopathological changes observed in the CNS parenchyma during EAE, are similarly observed in the BBB-deficient areas of the CVOs [22].
Positive_regulation (increased) of in perivascular macrophages Gene_expression (expression) of BBB in microglial cells associated with multiple sclerosis and central nervous system
10) Confidence 0.03 Published 2005 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC1262737 Disease Relevance 0.60 Pain Relevance 0.12
The most widely used polyamine molecule in the case of BBB transfer is probably the synthetic hexamethylenediamine or HMD (1,9).
Positive_regulation (transfer) of Gene_expression (transfer) of BBB
11) Confidence 0.03 Published 2008 Journal AAPS J Section Body Doc Link PMC2761699 Disease Relevance 0 Pain Relevance 0
If the NMO model is consistent with the human disease, it can be used to examine how changes in AQP4 expression and blood-brain barrier (BBB) integrity, both of which can be regulated by CNS inflammation, contribute to inductive events for anti-AQP4-specific immune response.
Positive_regulation (inductive) of Gene_expression (expression) of BBB in blood associated with neuromyelitis optica, inflammation, central nervous system and disease
12) Confidence 0.02 Published 2008 Journal J Neuroinflammation Section Abstract Doc Link PMC2427020 Disease Relevance 1.76 Pain Relevance 0.23

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