INT173514

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Context Info
Confidence 0.06
First Reported 2002
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 3.49
Pain Relevance 0.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeleton (Alms1) cilium (Alms1) molecular_function (Alms1)
lipid metabolic process (Alms1) cytoplasm (Alms1)
Anatomy Link Frequency
eyes 2
neutrophil 2
T-cell 2
Alms1 (Mus musculus)
Pain Link Frequency Relevance Heat
Central nervous system 48 98.20 Very High Very High Very High
Multiple sclerosis 37 97.64 Very High Very High Very High
cytokine 31 94.08 High High
Inflammation 43 90.80 High High
imagery 2 89.64 High High
rheumatoid arthritis 37 82.72 Quite High
Neuritis 12 63.84 Quite High
anesthesia 2 46.24 Quite Low
chemokine 8 45.36 Quite Low
Inflammatory response 7 39.24 Quite Low
Disease Link Frequency Relevance Heat
Adhesions 14 100.00 Very High Very High Very High
Targeted Disruption 19 99.54 Very High Very High Very High
Convulsion 3 98.54 Very High Very High Very High
Coma 3 98.34 Very High Very High Very High
Multiple Sclerosis 81 97.64 Very High Very High Very High
Cerebral Malaria 30 97.64 Very High Very High Very High
INFLAMMATION 52 90.80 High High
Death 6 86.72 High High
Malaria 2 86.64 High High
Hypothermia 1 85.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
AAV-delivered catalase to the right eyes of transgenic ECSOD mice (ECSOD OD) reduced disruption of the BBB by 63%, with a mean value of 62 extravasated immunogold particles per 2.6x106 ?
Negative_regulation (reduced) of Gene_expression (disruption) of BBB in eyes associated with targeted disruption
1) Confidence 0.06 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2504532 Disease Relevance 0.45 Pain Relevance 0.10
may downregulate expression of adhesion molecules on the BBB, which inhibits T-cell trafficking into the CNS.
Spec (may) Negative_regulation (downregulate) of Gene_expression (expression) of BBB in T-cell associated with central nervous system and adhesions
2) Confidence 0.05 Published 2002 Journal Arthritis Res Section Body Doc Link PMC153843 Disease Relevance 1.49 Pain Relevance 0.65
The model used for this study shows however main features also seen in human CM: A clinical picture including coma, seizures and neurological impairment, strong histopathological similarities with impairment of the BBB and petechial bleedings and a systemic as well as a local immune responses having TNF, INF-?
Negative_regulation (impairment) of Gene_expression (petechial) of BBB associated with convulsion, coma and cerebral malaria
3) Confidence 0.04 Published 2008 Journal Malar J Section Body Doc Link PMC2257967 Disease Relevance 1.48 Pain Relevance 0.09
Neutrophils have been implicated in mediating this effect based on a study in rats where administration of anti-CINC-1 (CXCL1) neutralizing antibodies attenuated neutrophil recruitment and BBB breakdown downstream of intracerebral IL-1?
Negative_regulation (downstream) of Gene_expression (breakdown) of BBB in neutrophil
4) Confidence 0.04 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2335091 Disease Relevance 0.07 Pain Relevance 0.08

General Comments

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