INT173519

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Context Info
Confidence 0.49
First Reported 2002
Last Reported 2011
Negated 0
Speculated 4
Reported most in Body
Documents 27
Total Number 32
Disease Relevance 24.48
Pain Relevance 3.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
neuronal 4
B cells 2
muscles 2
astrocytes 2
NK cells 2
IFNA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Multiple sclerosis 964 100.00 Very High Very High Very High
cytokine 617 100.00 Very High Very High Very High
rheumatoid arthritis 122 100.00 Very High Very High Very High
Dopamine 183 99.38 Very High Very High Very High
Inflammation 452 99.36 Very High Very High Very High
agonist 72 97.68 Very High Very High Very High
headache 11 96.96 Very High Very High Very High
cva 17 94.52 High High
dopaminergic neurodegeneration 3 92.64 High High
chemokine 63 88.08 High High
Disease Link Frequency Relevance Heat
Multiple Sclerosis 1051 100.00 Very High Very High Very High
Fatigue 150 100.00 Very High Very High Very High
Rheumatoid Arthritis 122 100.00 Very High Very High Very High
Toxicity 118 100.00 Very High Very High Very High
Status Epilepticus 9 100.00 Very High Very High Very High
Influenza Virus Infection 387 99.80 Very High Very High Very High
Dengue 252 99.76 Very High Very High Very High
Sprains And Strains 57 99.44 Very High Very High Very High
INFLAMMATION 529 99.36 Very High Very High Very High
Apoptosis 86 99.28 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For instance, apigenin and luteolin appear to regulate serine 727 phosphorylation of STAT1 at levels that are potentially conducive to apoptosis, all the while keeping a damper on levels in the presence of IFN-?
Positive_regulation (levels) of Localization (presence) of IFN associated with apoptosis
1) Confidence 0.49 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2569027 Disease Relevance 0.56 Pain Relevance 0.21
M of apigenin or luteolin in the presence of a stimulatory amount of IFN-?
Positive_regulation (stimulatory) of Localization (amount) of IFN
2) Confidence 0.49 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2569027 Disease Relevance 0.16 Pain Relevance 0
AQP4 p21-40-primed T cells secreted both IFN-?
Positive_regulation (primed) of Localization (secreted) of IFN in T cells
3) Confidence 0.49 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2994828 Disease Relevance 0.79 Pain Relevance 0.07
When the patients who were initially non-responders to IFN treatment were retreated with CIFN (15 ?
Positive_regulation (responders) of Localization (treatment) of IFN
4) Confidence 0.28 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727894 Disease Relevance 1.27 Pain Relevance 0
A strong type I IFN response and the identification of viperin as an IFN-induced anti-dengue molecule
Positive_regulation (induced) of Localization (response) of IFN associated with dengue
5) Confidence 0.17 Published 2007 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2100376 Disease Relevance 1.49 Pain Relevance 0
A strong type I IFN response and the identification of viperin as an IFN-induced anti-dengue molecule
Positive_regulation (induced) of Localization (response) of IFN associated with dengue
6) Confidence 0.17 Published 2007 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2100376 Disease Relevance 1.49 Pain Relevance 0
Both compounds induce secretion of IFN-?
Positive_regulation (induce) of Localization (secretion) of IFN
7) Confidence 0.17 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2933899 Disease Relevance 0.66 Pain Relevance 0.30
Systemic release of high levels of IFN is known to cause numerous unwanted side effects including: fever, chills, headaches, achy muscles, diarrhea, loss of appetite, anemia, increased bleeding and bruising, and birth defects.
Positive_regulation (levels) of Localization (release) of IFN in muscles associated with anaemia, diarrhoea, congenital anomalies, chills, anorexia, cva, headache and fever
8) Confidence 0.17 Published 2006 Journal Biol Proced Online Section Body Doc Link PMC1489265 Disease Relevance 0.91 Pain Relevance 0.14
secretion, we propose that E2 activates B cells viability through promoting PDCs to secrete more IFN-?
Positive_regulation (promoting) of Localization (secrete) of IFN in B cells
9) Confidence 0.14 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2793013 Disease Relevance 0 Pain Relevance 0.08
This gene mutation abrogates type I IFN secretion as well as pro-inflammatory cytokine production upon TLR agonist ligation.
Positive_regulation (abrogates) of Localization (secretion) of IFN associated with inflammation, agonist and cytokine
10) Confidence 0.10 Published 2007 Journal J Transl Med Section Body Doc Link PMC2176053 Disease Relevance 0.94 Pain Relevance 0.18
In humans, influenza H5N1 virus mediates a cytokine storm characterized by insensitivity to the antiviral effects of IFN (possibly due to insufficient production) and increased concentration of IFN-?
Positive_regulation (increased) of Localization (concentration) of IFN associated with influenza virus infection and cytokine
11) Confidence 0.07 Published 2008 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2635754 Disease Relevance 1.46 Pain Relevance 0.29
PBMCs from CpG ODN-vaccinated subjects responded to in vitro re-stimulation by secreting significantly higher levels of IFN-?
Positive_regulation (levels) of Localization (secreting) of IFN
12) Confidence 0.07 Published 2008 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2635754 Disease Relevance 0.37 Pain Relevance 0.04
This, in turn, stimulates T cells to secrete additional cytokines and NK cells to secrete IFN-?
Positive_regulation (stimulates) of Localization (secrete) of IFN in NK cells associated with cytokine
13) Confidence 0.07 Published 2008 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2635754 Disease Relevance 0.26 Pain Relevance 0.21
Covalent linkage of CpG ODN to influenza virus HA resulted in secretion of high levels of IFN- and HA-specific IgG2a antibodies [122] suggesting that crosslinking CpG ODNs to peptides may be an efficient adjuvant method.
Positive_regulation (resulted) of Localization (secretion) of IFN associated with influenza virus infection
14) Confidence 0.06 Published 2008 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2635754 Disease Relevance 1.02 Pain Relevance 0.04
However, in this study, CD4+ T cell-mediated DA neuronal loss was found to be dependent on the presence of the TNF ligand family member, FasL, and not IFN-?.
Positive_regulation (dependent) of Localization (presence) of IFN in neuronal associated with dopamine
15) Confidence 0.05 Published 2011 Journal Parkinson's Disease Section Body Doc Link PMC3018622 Disease Relevance 0.83 Pain Relevance 0.32
-induced activation of astrocytes attenuated hippocampal neuronal damage after status epilepticus (SE) in rats, while neutralization of astrocytic IFN-?
Positive_regulation (induced) of Localization (neutralization) of IFN in neuronal associated with status epilepticus
16) Confidence 0.05 Published 2011 Journal Parkinson's Disease Section Body Doc Link PMC3018622 Disease Relevance 0.93 Pain Relevance 0.03
In addition to microglia, recent evidence suggests that astrocytes may mediate some of the central immunomodulatory actions of IFN-?
Spec (may) Positive_regulation (mediate) of Localization (actions) of IFN in astrocytes
17) Confidence 0.05 Published 2011 Journal Parkinson's Disease Section Body Doc Link PMC3018622 Disease Relevance 0.89 Pain Relevance 0.07
The main end-point of this study is to investigate whether the increase of dose intensity, and the related increase in IFN concentration, obtained by the exclusive intravenous administration of IFN?
Spec (whether) Positive_regulation (increase) of Localization (concentration) of IFN
18) Confidence 0.05 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1421423 Disease Relevance 0.76 Pain Relevance 0.07
RIIa and reach the endosomal compartment where they activate TLR7 and TLR, respectively, leading to secretion of cytokines such as IFN-?
Positive_regulation (leading) of Localization (secretion) of IFN associated with cytokine
19) Confidence 0.04 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2933908 Disease Relevance 0.34 Pain Relevance 0.12
Barriers to adherence thus include needle phobia and coping with the aforementioned AEs as well as others, but also include additional issues, such as not taking medication because of forgetfulness, complacency, treatment fatigue, changes in socioeconomic circumstances, and perceived lack of efficacy.24 Specifically related to GA, a study by Haas and Firzlaff of 308 patients with RRMS conducted over 24 months indicated a significantly (P < 0.001) lower discontinuation rate for GA compared with the 3 IFN-based therapies.25 However, regardless of whether patients are treated with IFN?
Positive_regulation (-) of Localization (based) of IFN associated with phobia, multiple sclerosis and fatigue
20) Confidence 0.04 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2857614 Disease Relevance 0.97 Pain Relevance 0.10

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