INT173537

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Context Info
Confidence 0.40
First Reported 2003
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 18
Total Number 19
Disease Relevance 13.02
Pain Relevance 7.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (CCL16) extracellular region (CCL16) cell-cell signaling (CCL16)
Anatomy Link Frequency
leukocytes 3
capsules 1
lens capsule 1
lens 1
CCL16 (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 963 100.00 Very High Very High Very High
rheumatoid arthritis 426 99.94 Very High Very High Very High
cytokine 172 99.88 Very High Very High Very High
Inflammation 259 97.56 Very High Very High Very High
imagery 14 96.64 Very High Very High Very High
Multiple sclerosis 240 96.60 Very High Very High Very High
Central nervous system 200 94.88 High High
antagonist 35 91.88 High High
Pain 4 90.36 High High
headache 2 88.44 High High
Disease Link Frequency Relevance Heat
Neurocysticercosis 34 100.00 Very High Very High Very High
Epilepsy 54 99.98 Very High Very High Very High
Rheumatoid Arthritis 426 99.94 Very High Very High Very High
Disease 170 98.08 Very High Very High Very High
Syndrome 25 97.68 Very High Very High Very High
INFLAMMATION 266 97.56 Very High Very High Very High
Cataract 100 96.92 Very High Very High Very High
Demyelinating Disease 312 96.60 Very High Very High Very High
Capsule Opacification 204 95.24 Very High Very High Very High
Central Nervous System Disease 192 94.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This may explain why CCL16, although binding to a non-specific receptor, triggers a unique signalling cascade and provides evidence of differential regulatory mechanisms employed by chemokines to illicit cellular responses.
CCL16 Binding (binding) of associated with chemokine
1) Confidence 0.40 Published 2007 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1884154 Disease Relevance 0.67 Pain Relevance 0.25
LEC on capsules treated with drug for one week were allowed to recover in vehicle-only medium for a second week.
LEC Binding (recover) of in capsules
2) Confidence 0.11 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2765474 Disease Relevance 0 Pain Relevance 0
In ex vivo cultures of canine lens capsules, LEC migrate across the majority of the posterior lens capsule by 14 days following sham cataract surgery, a situation that mimics PCO formation in vivo [43].
LEC Binding (migrate) of in lens capsule associated with capsule opacification and cataract
3) Confidence 0.10 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2765474 Disease Relevance 0.75 Pain Relevance 0
A recent review of chemokines and their receptors [39] suggests that every CC chemokine receptor (CCR1-CCR5) interact with multiple CCLs and vice versa.
chemokine Binding (interact) of associated with chemokine
4) Confidence 0.10 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 1.14 Pain Relevance 0.51
Since the annual rate of incident cases of epilepsy due to neurocysticercosis is not known in the area but expected to be low, this parameter was estimated using the prevalence of epilepsy associated with NCC described above divided by the duration of the disease for each age category [23],[25].
NCC Binding (associated) of associated with epilepsy, disease and neurocysticercosis
5) Confidence 0.09 Published 2009 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2656639 Disease Relevance 1.22 Pain Relevance 0
On the other hand, the proportion of epilepsy associated with NCC used is this study was based on serological results which were not confirmed using imaging and electroencephalogram.
NCC Binding (associated) of associated with epilepsy, imagery and neurocysticercosis
6) Confidence 0.09 Published 2009 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2656639 Disease Relevance 1.69 Pain Relevance 0.14
Anterior lens capsules with adherent LEC were excised from each lens for protein extraction and immediately frozen and stored at ?
LEC Binding (lens capsules) of in lens
7) Confidence 0.08 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2994344 Disease Relevance 0.76 Pain Relevance 0
As evaluated by immunohistochemisty, normal canine LEC had minimal to no detectable pAkt protein present (Figure 1A), while immunostaining for pAkt was strong predominantly in the cytoplasm of naturally occurring cataractous canine LEC (Figure 1B) and clinical samples of canine PCO (Figure 1C).
LEC Neg (no) Binding (minimal) of associated with capsule opacification
8) Confidence 0.08 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2994344 Disease Relevance 0.24 Pain Relevance 0.04
CCL – CC chemokine ligand
chemokine Binding (ligand) of associated with chemokine
9) Confidence 0.08 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 1.88 Pain Relevance 0.62
Chemokine receptors tend to bind multiple chemokine ligands and vice versa.
Chemokine Binding (bind) of associated with chemokine
10) Confidence 0.08 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 0.50 Pain Relevance 0.62
Chemokine receptors tend to bind multiple chemokine ligands and vice versa.
chemokine Binding (bind) of associated with chemokine
11) Confidence 0.08 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 0.49 Pain Relevance 0.61
Following a wash to remove any unbound antibody-enzyme reagent, a substrate solution is added to the wells and color development in proportion to the amount of chemokine bound to the plate is measured as optical density based on the color intensity using a spectrophotometer at a specific wave length.
chemokine Binding (bound) of associated with chemokine
12) Confidence 0.00 Published 2003 Journal Biol Proced Online Section Body Doc Link PMC153847 Disease Relevance 0 Pain Relevance 0.28
Chemokines mediate their activities by binding to target cell surface chemokine receptors that belong to the large family of G protein-coupled, seven transmembrane (7 TM) domain receptors (also called serpentine receptors) (3).
chemokine Binding (binding) of associated with chemokine
13) Confidence 0.00 Published 2003 Journal Biol Proced Online Section Body Doc Link PMC153847 Disease Relevance 0.11 Pain Relevance 0.47
The released soluble fragments can bind chemokine molecules, thereby neutralizing their activity (9).
chemokine Binding (bind) of associated with chemokine
14) Confidence 0.00 Published 2003 Journal Biol Proced Online Section Body Doc Link PMC153847 Disease Relevance 0.16 Pain Relevance 0.68
Standards and samples are pipetted into the wells and the chemokine present in the sample or standard is bound by the immobilized antibody.
chemokine Binding (bound) of associated with chemokine
15) Confidence 0.00 Published 2003 Journal Biol Proced Online Section Body Doc Link PMC153847 Disease Relevance 0 Pain Relevance 0.30
Based on the receptor nomenclature established at the 1996 Gordon Research Conference on chemotactic cytokines, the chemokine receptors that bind CXC chemokines are designated CXCRs and the receptors that bind CC chemokines are designated CCRs.
chemokine Binding (bind) of associated with chemokine and cytokine
16) Confidence 0.00 Published 2003 Journal Biol Proced Online Section Body Doc Link PMC153847 Disease Relevance 0.32 Pain Relevance 0.53
Chemokine receptors in the rheumatoid synovium: upregulation of CXCR5

In patients with rheumatoid arthritis (RA), chemokine and chemokine receptor interactions play a central role in the recruitment of leukocytes into inflamed joints.

chemokine Binding (interactions) of in leukocytes associated with chemokine and rheumatoid arthritis
17) Confidence 0.00 Published 2005 Journal Arthritis Res Ther Section Title Doc Link PMC1065316 Disease Relevance 1.03 Pain Relevance 0.74
Chemokine activity is dependent on the presence of and interaction with chemokine receptors on the leukocyte surface.
chemokine Binding (interaction) of in leukocyte associated with chemokine
18) Confidence 0.00 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065316 Disease Relevance 1.05 Pain Relevance 0.82
Chemokine receptors in the rheumatoid synovium: upregulation of CXCR5

In patients with rheumatoid arthritis (RA), chemokine and chemokine receptor interactions play a central role in the recruitment of leukocytes into inflamed joints.

chemokine Binding (interactions) of in leukocytes associated with chemokine and rheumatoid arthritis
19) Confidence 0.00 Published 2005 Journal Arthritis Res Ther Section Title Doc Link PMC1065316 Disease Relevance 1.03 Pain Relevance 0.74

General Comments

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