INT173579

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Context Info
Confidence 0.03
First Reported 2003
Last Reported 2004
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.09
Pain Relevance 0.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (FDFT1) oxidoreductase activity (FDFT1) endoplasmic reticulum (FDFT1)
transferase activity, transferring alkyl or aryl (other than methyl) groups (FDFT1)
FDFT1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 3 92.00 High High
nud 1 91.04 High High
Bile 27 82.80 Quite High
metalloproteinase 58 58.64 Quite High
rheumatoid arthritis 15 52.76 Quite High
Inflammation 8 40.92 Quite Low
Osteoarthritis 15 5.00 Very Low Very Low Very Low
cytokine 6 5.00 Very Low Very Low Very Low
Arthritis 5 5.00 Very Low Very Low Very Low
Potency 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Esophageal Disease 1 96.24 Very High Very High Very High
Diarrhoea 1 92.56 High High
Pain 3 92.00 High High
Vomiting 2 91.44 High High
Dyspepsia 1 91.04 High High
Apoptosis 9 86.60 High High
Dental Calculus 1 76.68 Quite High
Calcification 7 71.60 Quite High
Disorder Of Lipid Metabolism 39 60.56 Quite High
Rheumatoid Arthritis 15 52.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Some of the nitrogen-containing bisphosphonates are potent inhibitors of squalene synthetase, one of the enzymes in the cholesterol biosynthesis pathway.
Negative_regulation (inhibitors) of squalene synthetase
1) Confidence 0.03 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC154424 Disease Relevance 1.03 Pain Relevance 0.19
In non-Gl mushroom species, inhibition of squalene synthetase by zaragozic acid fungal metabolites has also been reported in primates [45].
Negative_regulation (inhibition) of squalene synthetase
2) Confidence 0.01 Published 2004 Journal Lipids Health Dis Section Body Doc Link PMC385249 Disease Relevance 0.06 Pain Relevance 0.04

General Comments

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