INT173581

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Context Info
Confidence 0.38
First Reported 2003
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.46
Pain Relevance 0.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (ADAM12) mitochondrion (ADAM12) extracellular region (ADAM12)
cell adhesion (ADAM12) nucleolus (ADAM12) plasma membrane (ADAM12)
Anatomy Link Frequency
chondrocytes 1
cartilage 1
ADAM12 (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 8 99.84 Very High Very High Very High
Inflammation 24 97.32 Very High Very High Very High
Osteoarthritis 25 96.44 Very High Very High Very High
metalloproteinase 110 94.16 High High
Multiple sclerosis 4 91.40 High High
Demyelination 1 88.84 High High
Bioavailability 4 88.56 High High
Neuropathic pain 1 43.72 Quite Low
rheumatoid arthritis 22 17.20 Low Low
cytokine 8 12.84 Low Low
Disease Link Frequency Relevance Heat
Tendinopathy 2 99.52 Very High Very High Very High
Apoptosis 32 97.84 Very High Very High Very High
Disease Progression 4 97.72 Very High Very High Very High
INFLAMMATION 23 97.32 Very High Very High Very High
Osteoarthritis 30 96.44 Very High Very High Very High
Demyelinating Disease 5 91.40 High High
Disease 23 87.84 High High
Arthritis 20 83.92 Quite High
Neuropathic Pain 1 43.72 Quite Low
Renal Disease 1 41.48 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Both IGFBP-3 and IGFBP-5 are degraded by the disintegrin metalloprotease, ADAM-12 (meltrin-?)
Gene_expression (disintegrin metalloprotease) of ADAM-12
1) Confidence 0.38 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875662 Disease Relevance 0.25 Pain Relevance 0.09
Moreover, the extent of expression of ADAM12 by chondrocytes correlated with pathological markers of disease progression such as cell cloning and proliferation [49].
Gene_expression (expression) of ADAM12 in chondrocytes associated with disease progression
2) Confidence 0.34 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875662 Disease Relevance 0.34 Pain Relevance 0.09
ADAM-12 and MMP-23 are coexpressed in painful tendinopathy [139] suggesting a role for these in this inflammatory disorder.



Gene_expression (coexpressed) of ADAM-12 associated with pain, inflammation and tendinopathy
3) Confidence 0.11 Published 2011 Journal Biochemistry Research International Section Body Doc Link PMC2989751 Disease Relevance 0.69 Pain Relevance 0.49
ADAMTS-4 and ADAMTS-5 cleave proteoglycan [95], and ADAM-10, ADAM-12, ADAM-15 and ADAM-17 are also found in cartilage.
Gene_expression (found) of ADAM-12 in cartilage
4) Confidence 0.08 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC154424 Disease Relevance 0.17 Pain Relevance 0.17

General Comments

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