INT173582

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Context Info
Confidence 0.05
First Reported 2003
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 3.24
Pain Relevance 0.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (COL5A2) molecular_function (COL5A2)
Anatomy Link Frequency
cartilage 2
COL5A2 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 90 100.00 Very High Very High Very High
Osteoarthritis 15 99.36 Very High Very High Very High
rheumatoid arthritis 16 77.68 Quite High
Arthritis 5 66.76 Quite High
Inflammatory marker 4 50.00 Quite Low
Pain 8 5.44 Low Low
Inflammation 11 5.00 Very Low Very Low Very Low
cytokine 10 5.00 Very Low Very Low Very Low
fibrosis 7 5.00 Very Low Very Low Very Low
agonist 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Uterine Fibroids 240 99.56 Very High Very High Very High
Osteoarthritis 16 99.36 Very High Very High Very High
Severe Combined Immunodeficiency 2 99.32 Very High Very High Very High
Apoptosis 31 99.24 Very High Very High Very High
Cancer 92 95.48 Very High Very High Very High
Targeted Disruption 5 89.92 High High
Arthritis 16 87.84 High High
Ovarian Cancer 2 79.84 Quite High
Rheumatoid Arthritis 64 77.68 Quite High
Renal Failure 4 52.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
With a decrease in soluble collagen secretion, we hypothesized that the expression of individual ECM components known to be disrupted in leiomyomas may also be regulated by ATRA.
Negative_regulation (decrease) of Localization (secretion) of collagen associated with uterine fibroids
1) Confidence 0.05 Published 2008 Journal Clinical Endocrinology Section Body Doc Link PMC2610401 Disease Relevance 0.82 Pain Relevance 0
As shown in Fig. 2, leiomyoma cells demonstrated a decrease in collagen secretion with increasing ATRA exposure.
Negative_regulation (decrease) of Localization (secretion) of collagen associated with uterine fibroids
2) Confidence 0.05 Published 2008 Journal Clinical Endocrinology Section Body Doc Link PMC2610401 Disease Relevance 0.84 Pain Relevance 0
As distending pressure increases, there is greater recruitment of relatively inelastic collagen fibres and, consequently, a reduction in elasticity (Bank et al 1996).
Negative_regulation (reduction) of Localization (recruitment) of collagen
3) Confidence 0.02 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2663454 Disease Relevance 0.05 Pain Relevance 0
There is good evidence that, in OA, MMP-13 is responsible for much of the collagen degradation in cartilage as MMP-13-specific synthetic inhibitors completely block the release of collagen fragments from OA cartilage [104].
Negative_regulation (block) of Localization (release) of collagen in cartilage associated with osteoarthritis
4) Confidence 0.02 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC154424 Disease Relevance 0.59 Pain Relevance 0.22
Alendronate blocked MMPs secretion and bone collagen release by PC3 cells in SCID mice [51].
Negative_regulation (blocked) of Localization (secretion) of collagen associated with severe combined immunodeficiency and metalloproteinase
5) Confidence 0.01 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1828067 Disease Relevance 0.46 Pain Relevance 0.10
Alendronate blocked MMPs secretion and bone collagen release by PC3 cells in SCID mice [51].
Negative_regulation (blocked) of Localization (release) of collagen associated with severe combined immunodeficiency and metalloproteinase
6) Confidence 0.01 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1828067 Disease Relevance 0.47 Pain Relevance 0.10

General Comments

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