INT173588

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Context Info
Confidence 0.01
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.08
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (CDC42EP5) cytoskeleton (CDC42EP5) cytoplasm (CDC42EP5)
Anatomy Link Frequency
osteoclast 1
CDC42EP5 (Homo sapiens)
Pain Link Frequency Relevance Heat
imagery 6 69.84 Quite High
metalloproteinase 58 50.00 Quite Low
rheumatoid arthritis 15 5.00 Very Low Very Low Very Low
Osteoarthritis 15 5.00 Very Low Very Low Very Low
Inflammation 7 5.00 Very Low Very Low Very Low
cytokine 6 5.00 Very Low Very Low Very Low
Pain 6 5.00 Very Low Very Low Very Low
Arthritis 5 5.00 Very Low Very Low Very Low
Potency 5 5.00 Very Low Very Low Very Low
corticosteroid 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 90 97.08 Very High Very High Very High
Apoptosis 9 95.48 Very High Very High Very High
Hypercalcemia 16 70.08 Quite High
Calcification 7 11.20 Low Low
Arthritis 16 5.00 Very Low Very Low Very Low
Osteoarthritis 16 5.00 Very Low Very Low Very Low
Rheumatoid Arthritis 15 5.00 Very Low Very Low Very Low
Cancer 10 5.00 Very Low Very Low Very Low
INFLAMMATION 8 5.00 Very Low Very Low Very Low
Pain 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Rab GTPases switch between the GTP-bound state in which they are active and membrane-associated and the GDP-bound state in which they are inactive and cytosolic.
Negative_regulation (switch) of GTPases
1) Confidence 0.01 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2830827 Disease Relevance 0.64 Pain Relevance 0.03
It is believed that the more potent nitrogen-containing bisphosphonates inhibit osteoclast function by inhibiting these small GTPases.
Negative_regulation (inhibiting) of GTPases in osteoclast
2) Confidence 0.00 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC154424 Disease Relevance 0.44 Pain Relevance 0

General Comments

This test has worked.

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