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Context Info
Confidence 0.58
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.65
Pain Relevance 1.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (OSM) extracellular space (OSM) extracellular region (OSM)
Anatomy Link Frequency
joints 1
platelet 1
epithelial cells 1
OSM (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 160 98.64 Very High Very High Very High
cytokine 141 97.36 Very High Very High Very High
chemokine 20 87.68 High High
Inflammation 60 85.00 Quite High
fibrosis 2 72.28 Quite High
Pain 3 24.64 Low Low
nud 1 23.68 Low Low
Inflammatory response 2 8.24 Low Low
COX-2 inhibitor 23 5.00 Very Low Very Low Very Low
rheumatoid arthritis 15 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 104 99.68 Very High Very High Very High
Herpes Simplex Virus 238 99.48 Very High Very High Very High
Carcinoma 16 98.40 Very High Very High Very High
INFLAMMATION 73 85.00 Quite High
Malignant Neoplastic Disease 8 72.92 Quite High
Fibrosis 2 72.28 Quite High
Cancer 36 53.84 Quite High
Sarcoma 79 50.00 Quite Low
Apoptosis 27 50.00 Quite Low
Metaplasia 8 42.84 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
OSM and secreted macrophage factors attenuate proliferation of bronchial epithelial cells
Localization (secreted) of OSM in epithelial cells
1) Confidence 0.58 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1289280 Disease Relevance 0.40 Pain Relevance 0.03
For pull-down experiments, vectors encoding FLAG-tagged Krit1 and OSM were transfected into HEK293 cells (the American Type Culture Collection (ATCC) Rockville, MA, USA) using lipofectamine.
Localization (transfected) of OSM
2) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2909203 Disease Relevance 0 Pain Relevance 0
KSHV infection stimulated the secretion of growth factors and angiogenic factors such as insulin-like growth factor-1 (IGF-1), platelet derived growth factor-BB (PDGF-BB), macrophage colony stimulating factor (M-CSF), granulocyte colony-stimulating factor (G-CSF), GM-CSF, angiogenin (Ang), oncostatin-M (Onco-M), TPO (thrombopoietin), VEGF, stromal cell-derived factor-1 (SDF-1), SCF (stem cell factor), TGF-?
Localization (secretion) of oncostatin-M in platelet associated with herpes simplex virus and infection
3) Confidence 0.10 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2820536 Disease Relevance 1.24 Pain Relevance 0.55
, IL-17 and oncostatin M, and these agents are found within inflamed joints.
Localization (found) of oncostatin M in joints
4) Confidence 0.07 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC154424 Disease Relevance 0 Pain Relevance 0.49

General Comments

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