INT173592

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.33
First Reported 2003
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 32
Total Number 33
Disease Relevance 9.14
Pain Relevance 2.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (COL5A2) molecular_function (COL5A2)
Anatomy Link Frequency
tendon 4
cleavage 3
muscle 1
epithelial cell 1
platelet 1
COL5A2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 127 98.86 Very High Very High Very High
Osteoarthritis 538 91.72 High High
agonist 20 90.32 High High
cINOD 34 87.52 High High
metalloproteinase 80 86.96 High High
Catecholamine 2 79.92 Quite High
Mechanotransduction 1 77.88 Quite High
cytokine 60 77.04 Quite High
rheumatoid arthritis 166 72.84 Quite High
Pain 82 68.88 Quite High
Disease Link Frequency Relevance Heat
Rupture 49 99.84 Very High Very High Very High
INFLAMMATION 127 98.86 Very High Very High Very High
Intervertebral Disk Degeneration 78 98.80 Very High Very High Very High
Adhesions 341 98.44 Very High Very High Very High
Disease 253 98.40 Very High Very High Very High
Syndrome 14 95.24 Very High Very High Very High
Rotator Cuff Tears 4 94.10 High High
Obesity 21 93.60 High High
Sprains And Strains 57 93.20 High High
Tendinopathy 36 92.72 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The role of collagen in the tendon has been studied extensively, and rotator cuff injury is one of the best examples of a tendon rupture syndrome related to abnormal collagen synthesis.13,14 It was admitted that tendon degeneration could be caused by repetitive microinjuries, which are subsequently repaired by removal of damaged matrix and deposition of newly abnormal synthesized collagen liable to rupture.13,14
collagen Binding (liable) of in tendon associated with syndrome, rupture and rotator cuff tears
1) Confidence 0.33 Published 2008 Journal Clinics Section Body Doc Link PMC2664193 Disease Relevance 0.71 Pain Relevance 0.03
The association between type V collagen and blood vessels also interferes epithelial cell migration during the healing process.
collagen Binding (association) of in epithelial cell
2) Confidence 0.29 Published 2008 Journal Clinics Section Body Doc Link PMC2664193 Disease Relevance 0.48 Pain Relevance 0
The inflammatory process is negligible in diseased tendons, where type I collagen is found in minor proportion, diffusely distributed, and grossly surrounded by type III fibrils.
collagen Binding (surrounded) of in tendons associated with inflammation
3) Confidence 0.29 Published 2008 Journal Clinics Section Body Doc Link PMC2664193 Disease Relevance 0.36 Pain Relevance 0.05
As a further additive glutaric aldehyde can be helpful with protein fixation of collagen fibers.
collagen Binding (helpful) of
4) Confidence 0.25 Published 2003 Journal Biomed Eng Online Section Body Doc Link PMC222922 Disease Relevance 0.08 Pain Relevance 0
The antibody does not interact with native type II collagen but there is activity against homologous sequence in type XI collagen [?
collagen Neg (not) Binding (interact) of
5) Confidence 0.13 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2716783 Disease Relevance 0.27 Pain Relevance 0.07
Specificity of the assay for type II collagen is achieved with the capture mAb 5109 (Otterness et al. 1999; Downs et al. 2001), which is only capable of binding type II collagen in monomeric as opposed to native triple helical collagen conformation.
collagen Binding (binding) of
6) Confidence 0.13 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2716783 Disease Relevance 0.28 Pain Relevance 0.14
The detection monoclonal antibody (mAb) used in this assay, 9A4, binds the type II collagen neoepitope generated at the new C-terminus on the collagen ¾ fragment following collagen cleavage and detects the same collagen neoepitope as C1,2C (Otterness et al. 1999).
collagen Binding (binds) of in cleavage
7) Confidence 0.13 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2716783 Disease Relevance 0.56 Pain Relevance 0.28
Scanning electron and fluorescence microscopy were employed to observe cell morphology and cell collagen gel interactions.
collagen Binding (interactions) of
8) Confidence 0.13 Published 2009 Journal Reprod Biol Endocrinol Section Abstract Doc Link PMC2645409 Disease Relevance 0.23 Pain Relevance 0.04
Effect of thrombin treatment on hUtSMC collagen contractility
collagen Binding (contractility) of
9) Confidence 0.12 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2645409 Disease Relevance 0 Pain Relevance 0
The detection monoclonal antibody (mAb) used in this assay, 9A4, binds the type II collagen neoepitope generated at the new C-terminus on the collagen ¾ fragment following collagen cleavage and detects the same collagen neoepitope as C1,2C (Otterness et al. 1999).
collagen Binding (binds) of in cleavage
10) Confidence 0.12 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2716783 Disease Relevance 0.56 Pain Relevance 0.28
Groups of mature collagen fibrils associate in regular staggered arrays and undergo cross-linking to form larger fibrils and fibers (Gelse et al. 2003).
collagen Binding (associate) of
11) Confidence 0.11 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2716783 Disease Relevance 0.09 Pain Relevance 0.09
The detection monoclonal antibody (mAb) used in this assay, 9A4, binds the type II collagen neoepitope generated at the new C-terminus on the collagen ¾ fragment following collagen cleavage and detects the same collagen neoepitope as C1,2C (Otterness et al. 1999).
collagen Binding (cleavage) of in cleavage
12) Confidence 0.10 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2716783 Disease Relevance 0.48 Pain Relevance 0.24
Matrix turnover (degradation of damaged collagen by MMPs, and its replacement by newly synthesised collagen) in turn is a function of the cells present in the tendon.
collagen Binding (replacement) of in tendon
13) Confidence 0.07 Published 2008 Journal J Orthop Surg Section Body Doc Link PMC2515295 Disease Relevance 0.09 Pain Relevance 0
Stimulation of cell-seeded collagen gel samples
collagen Binding (samples) of
14) Confidence 0.05 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC2921357 Disease Relevance 0 Pain Relevance 0
To date, there are no known associations of polymorphisms in collagen type IV and/or collagen type X genes, with intervertebral disc disease.

4.4 Sox9

collagen Neg (no) Binding (associations) of in intervertebral disc associated with disease
15) Confidence 0.05 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2532796 Disease Relevance 0.41 Pain Relevance 0
4.2 Type I collagen
collagen Binding (4.2) of
16) Confidence 0.04 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2532796 Disease Relevance 0.75 Pain Relevance 0
Another difference is that tendon may have up to 34% higher pyridinoline content, a mature collagen crosslinker, compared to ligament (normalized to collagen content) [3].
collagen Binding (crosslinker) of in tendon
17) Confidence 0.03 Published 2010 Journal Sports Med Arthrosc Rehabil Ther Technol Section Body Doc Link PMC2939640 Disease Relevance 0 Pain Relevance 0
Gene filter data from two patients also showed similar pattern of collagen, type 1 (alpha 2), fibronectin 1, MMP-1, TGF-?
collagen Binding (pattern) of
18) Confidence 0.03 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC548295 Disease Relevance 0.68 Pain Relevance 0.03
The HAM’s basement membrane contains type IV collagen, ln-1, Ln-5, fibronectin, and collagen VII.
collagen Binding (contains) of in basement membrane
19) Confidence 0.03 Published 2008 Journal Clinical ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2693999 Disease Relevance 0.38 Pain Relevance 0.03
Unfortunately, no method yet exists to organize and crosslink collagen fibers in a cytocompatible manner, and as such collagen gels remain exceptionally weak with typical elastic moduli between 10-30 kPa and ultimate tensile strengths between 5-10 kPa [41].
collagen Binding (crosslink) of
20) Confidence 0.03 Published 2010 Journal Sports Med Arthrosc Rehabil Ther Technol Section Body Doc Link PMC2939640 Disease Relevance 0 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox