INT173597

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Context Info
Confidence 0.14
First Reported 2003
Last Reported 2003
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.83
Pain Relevance 0.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (MMP2, Mmp13) peptidase activity (MMP2, Mmp13) extracellular region (MMP2, Mmp13)
proteinaceous extracellular matrix (MMP2, Mmp13) Golgi apparatus (Mmp13) nucleus (MMP2)
MMP2 (Homo sapiens)
Mmp13 (Mus musculus)
Pain Link Frequency Relevance Heat
Potency 10 100.00 Very High Very High Very High
Arthritis 10 97.44 Very High Very High Very High
metalloproteinase 116 82.72 Quite High
rheumatoid arthritis 30 5.00 Very Low Very Low Very Low
Osteoarthritis 30 5.00 Very Low Very Low Very Low
Inflammation 14 5.00 Very Low Very Low Very Low
cytokine 12 5.00 Very Low Very Low Very Low
Pain 6 5.00 Very Low Very Low Very Low
corticosteroid 2 5.00 Very Low Very Low Very Low
fibrosis 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Arthritis 32 97.44 Very High Very High Very High
Cancer 20 90.00 High High
Stomach Cancer 2 66.16 Quite High
Hypercalcemia 32 52.24 Quite High
Apoptosis 18 19.80 Low Low
Targeted Disruption 10 11.64 Low Low
Osteoarthritis 32 5.00 Very Low Very Low Very Low
Rheumatoid Arthritis 30 5.00 Very Low Very Low Very Low
Disease 28 5.00 Very Low Very Low Very Low
INFLAMMATION 16 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Two examples of nonpeptidyl hydroxamate inhibitors are prinomastat (AG-3340; Agouron, San Diego, USA) inhibitor, which is selective for gelatinases over collagenases, and Ro32-3555 (Roche, Basel, Switzerland), which is an effective inhibitor of collagenases but has less potency against MMP-2 and MMP-3.


Negative_regulation (inhibitor) of MMP-2 Binding (potency) of collagenase associated with potency
1) Confidence 0.14 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC154424 Disease Relevance 0.42 Pain Relevance 0.24
Two examples of nonpeptidyl hydroxamate inhibitors are prinomastat (AG-3340; Agouron, San Diego, USA) inhibitor, which is selective for gelatinases over collagenases, and Ro32-3555 (Roche, Basel, Switzerland), which is an effective inhibitor of collagenases but has less potency against MMP-2 and MMP-3.


Negative_regulation (inhibitor) of MMP-2 Binding (potency) of collagenase associated with potency
2) Confidence 0.14 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC154424 Disease Relevance 0.41 Pain Relevance 0.24

General Comments

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