INT173610

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Context Info
Confidence 0.03
First Reported 2003
Last Reported 2003
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 2.13
Pain Relevance 1.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ptgir) plasma membrane (Ptgir) signal transducer activity (Ptgir)
Ptgir (Mus musculus)
Pain Link Frequency Relevance Heat
COX-2 inhibitor 63 99.92 Very High Very High Very High
Pain 3 95.32 Very High Very High Very High
Inflammation 21 94.52 High High
Analgesic 6 77.68 Quite High
Angina 3 66.00 Quite High
cINOD 18 61.00 Quite High
rheumatoid arthritis 6 57.60 Quite High
aspirin 33 52.40 Quite High
Arthritis 6 5.00 Very Low Very Low Very Low
diclofenac 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pressure And Volume Under Development 3 95.72 Very High Very High Very High
Pain 3 95.32 Very High Very High Very High
INFLAMMATION 21 94.52 High High
Targeted Disruption 15 91.08 High High
Coronary Artery Disease 12 87.92 High High
Arthritis 9 81.80 Quite High
Brain Hemorrhage 3 70.76 Quite High
Stroke 3 69.52 Quite High
Myocardial Infarction 21 67.64 Quite High
Heart Rate Under Development 3 67.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Selective COX-2 inhibitors have no effect on TXA2 production but, by decreasing PGI2 production, they may affect the homeostatic balance between prothrombotic TXA2 and antithrombotic PGI2, and may lead to an increase in thrombotic cardiovascular events [20,21].
Negative_regulation (decreasing) of Gene_expression (production) of PGI2 associated with cox-2 inhibitor
1) Confidence 0.03 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC154429 Disease Relevance 0.70 Pain Relevance 0.19
By decreasing vasodilatory and antiplatelet aggregatory PGI2 production, COX-2 inhibitors may tip the balance in favor of prothrombotic eicosanoids (thromboxane A2 [TXA2]) and may lead to increased cardiovascular thrombotic events [6].


Negative_regulation (decreasing) of Gene_expression (production) of PGI2 associated with cox-2 inhibitor
2) Confidence 0.02 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC154429 Disease Relevance 0.66 Pain Relevance 0.67
It has now been unequivocally demonstrated, however, that selective COX-2 inhibitors also decrease vascular prostacyclin (PGI2) production and may affect the homeostatic balance, leading to a prothrombotic state [5].
Negative_regulation (decrease) of Gene_expression (production) of PGI2 associated with cox-2 inhibitor
3) Confidence 0.02 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC154429 Disease Relevance 0.77 Pain Relevance 0.83

General Comments

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