INT173623

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Context Info
Confidence 0.30
First Reported 2003
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 0.95
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (SP1) nucleus (SP1) intracellular (SP1)
DNA binding (SP1) transcription factor binding (SP1) cytoplasm (SP1)
Anatomy Link Frequency
proximal 4
SP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 12 49.80 Quite Low
Kinase C 141 45.84 Quite Low
cINOD 5 9.60 Low Low
cytokine 8 5.00 Very Low Very Low Very Low
Central nervous system 5 5.00 Very Low Very Low Very Low
dexamethasone 4 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
rheumatoid arthritis 2 5.00 Very Low Very Low Very Low
Osteoarthritis 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 10 94.88 High High
Familial Adenomatous Polyposis 8 88.40 High High
Colon Cancer 3 75.76 Quite High
Aging 16 70.56 Quite High
Cervical Cancer 3 39.36 Quite Low
Focal Cartilage Defect 6 27.68 Quite Low
Osteoarthritis 8 13.16 Low Low
INFLAMMATION 5 8.16 Low Low
Cancer 48 5.00 Very Low Very Low Very Low
Osteoporosis 16 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Both of these transcription factors (Sp1 and NF-?
Positive_regulation (factors) of Transcription (transcription) of Sp1
1) Confidence 0.30 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0.13 Pain Relevance 0
on hTERT mRNA expression may also be mediated by the transcription factors Sp1 and NF-?
Positive_regulation (factors) of Transcription (transcription) of Sp1
2) Confidence 0.30 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0.14 Pain Relevance 0
on hTERT mRNA expression may also be mediated by the transcription factors Sp1 and NF-?
Positive_regulation (on) of Transcription (transcription) of Sp1
3) Confidence 0.30 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0.14 Pain Relevance 0
At the level of transcriptional regulation, changes in the levels of cellular binding of the transcription factors Sp-1 and AP-2 to their cognate response DNA sequences contained within the proximal promoter region of the gene of a cartilage matrix component, aggrecan, are indeed the targets of TGF-?
Positive_regulation (cellular) of Transcription (transcription) of Sp-1 in proximal
4) Confidence 0.06 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC154434 Disease Relevance 0.27 Pain Relevance 0
At the level of transcriptional regulation, changes in the levels of cellular binding of the transcription factors Sp-1 and AP-2 to their cognate response DNA sequences contained within the proximal promoter region of the gene of a cartilage matrix component, aggrecan, are indeed the targets of TGF-?
Positive_regulation (factors) of Transcription (transcription) of Sp-1 in proximal
5) Confidence 0.06 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC154434 Disease Relevance 0.27 Pain Relevance 0

General Comments

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