INT173626

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Context Info
Confidence 0.47
First Reported 2002
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 9
Total Number 13
Disease Relevance 3.28
Pain Relevance 0.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (MSC) DNA binding (MSC)
Anatomy Link Frequency
joint 1
neuronal 1
nerve 1
Stem 1
mononuclear cell 1
MSC (Homo sapiens)
Pain Link Frequency Relevance Heat
methadone 16 99.04 Very High Very High Very High
Pain 24 97.24 Very High Very High Very High
cytokine 50 95.00 High High
Inflammation 46 94.60 High High
Nerve growth factor 1 92.00 High High
anesthesia 24 82.96 Quite High
Arthritis 11 77.08 Quite High
Osteoarthritis 12 65.32 Quite High
backache 2 60.36 Quite High
dexamethasone 13 48.20 Quite Low
Disease Link Frequency Relevance Heat
Osteoporosis 55 99.52 Very High Very High Very High
Death 2 99.32 Very High Very High Very High
Necrosis 48 98.12 Very High Very High Very High
Arthralgia 8 97.48 Very High Very High Very High
Aseptic Necrosis Of Bone 12 96.74 Very High Very High Very High
Cancer 5 96.24 Very High Very High Very High
Thrombosis 3 95.48 Very High Very High Very High
INFLAMMATION 57 94.60 High High
Opiate Addiction 6 84.64 Quite High
Apoptosis 6 84.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In both pathological conditions, some impairment of the cellular part of the repair could exist: a reduction of MSC and of the osteoblastic activation.
Negative_regulation (reduction) of MSC associated with osteoporosis
1) Confidence 0.47 Published 2010 Journal Stem Cells International Section Body Doc Link PMC2964482 Disease Relevance 0.84 Pain Relevance 0
Phases 1–3 Clinical Trials Using Adult Stem Cells in Osteonecrosis and Nonunion Fractures

Nonunion fractures and aseptic bone necrosis are two pathological conditions having some impairment of the cellular part of the repair: a reduction of MSC and of the osteoblastic activation.

Negative_regulation (reduction) of MSC in Stem associated with necrosis, aseptic necrosis of bone and osteoporosis
2) Confidence 0.47 Published 2010 Journal Stem Cells International Section Title Doc Link PMC2964482 Disease Relevance 0.53 Pain Relevance 0
Several preliminary reports have been published using data from a randomized, controlled study evaluating the effectiveness of MSC for patients receiving methadone.
Negative_regulation (effectiveness) of MSC associated with methadone
3) Confidence 0.37 Published 2002 Journal Sci Pract Perspect Section Body Doc Link PMC2851064 Disease Relevance 0.17 Pain Relevance 0.10
They quantified the number of injected MSC and found a significant lower count of MSC in the negative cases.

2.3.

Negative_regulation (number) of MSC
4) Confidence 0.35 Published 2010 Journal Stem Cells International Section Body Doc Link PMC2964482 Disease Relevance 0.44 Pain Relevance 0.14
The aim of this study was to determine the prevalence of MSC, defined as those presenting with either peripheral or spinal joint pain, and their functional implications in a sample of people attending two community health centres in Cape Town, South Africa.


Spec (determine) Negative_regulation (prevalence) of MSC in joint associated with pain and arthralgia
5) Confidence 0.33 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2830178 Disease Relevance 0.54 Pain Relevance 0.29
For determining the starting number of MSC in the mononuclear cell fraction CFU-F assays were performed.
Spec (determining) Negative_regulation (number) of MSC in mononuclear cell
6) Confidence 0.25 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1829400 Disease Relevance 0 Pain Relevance 0
For recalculating the starting number of MSC in the MNC fraction, CFU assays were performed and the MSC frequency was determined.
Negative_regulation (number) of MSC
7) Confidence 0.25 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1829400 Disease Relevance 0 Pain Relevance 0
Recent studies demonstrated that treatment of MSC with chemical agents including DMSO/BHA induced a neuronal morphology causing by disruption of cytoskeleton, a loss of cell-adherence but BM-MSC showed signs of death [11,13,19].
Negative_regulation (loss) of BM-MSC in neuronal associated with death
8) Confidence 0.22 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2358905 Disease Relevance 0.27 Pain Relevance 0
000 cells of different donors of aMSC and pMSC, and also 200?
Negative_regulation (donors) of aMSC
9) Confidence 0.20 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2722022 Disease Relevance 0 Pain Relevance 0
000 cells of different donors of aMSC and pMSC, and also 200?
Negative_regulation (donors) of pMSC
10) Confidence 0.20 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2722022 Disease Relevance 0 Pain Relevance 0
At this stage the MSC proliferation medium was replaced with neural proliferation medium consisting of DMEM/ F12 (1:1), supplemented with 10% serum, 1 ng/ml bFGF (Sigma, USA), 50 ng/ml Human noggin (Peprotech, Germany), 2% B27 (Sigma, USA), and 100 ng/ml nerve growth factor (Sigma, USA).
Negative_regulation (replaced) of MSC in nerve associated with nerve growth factor
11) Confidence 0.12 Published 2010 Journal Asian Journal of Transfusion Science Section Body Doc Link PMC2847339 Disease Relevance 0 Pain Relevance 0.05
Initially the effect of priming on MSC mediated suppression of alloantigen and mitogen induced lymphoproliferation was evaluated in vitro.
Negative_regulation (suppression) of MSC
12) Confidence 0.08 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2814860 Disease Relevance 0.50 Pain Relevance 0.30
In addition, what is the developmental or evolutionary advantage to the decrease in MSC number?
Negative_regulation (decrease) of MSC
13) Confidence 0.08 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC154434 Disease Relevance 0 Pain Relevance 0

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