INT173632

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Context Info
Confidence 0.41
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 1.42
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (SP1) nucleus (SP1) intracellular (SP1)
DNA binding (SP1) transcription factor binding (SP1) cytoplasm (SP1)
Anatomy Link Frequency
proximal 1
SP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 6 91.20 High High
agonist 12 49.80 Quite Low
Kinase C 143 45.84 Quite Low
cytokine 16 31.20 Quite Low
Inflammation 4 17.52 Low Low
Central nervous system 6 5.00 Very Low Very Low Very Low
dexamethasone 2 5.00 Very Low Very Low Very Low
chemokine 2 5.00 Very Low Very Low Very Low
Migraine 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 7 93.92 High High
Viral Infection 1 93.76 High High
INFLAMMATION 10 90.80 High High
Acquired Immune Deficiency Syndrome Or Hiv Infection 141 88.00 High High
Familial Adenomatous Polyposis 4 87.44 High High
Cancer 93 86.80 High High
Colon Cancer 5 75.76 Quite High
Myotonic Dystrophy 8 75.00 Quite High
Aging 14 70.56 Quite High
Apoptosis 20 68.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Both of these transcription factors (Sp1 and NF-?
Transcription (transcription) of Sp1
1) Confidence 0.41 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0.13 Pain Relevance 0
on hTERT mRNA expression may also be mediated by the transcription factors Sp1 and NF-?
Transcription (transcription) of Sp1
2) Confidence 0.41 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0.14 Pain Relevance 0
Transcription factors such as c-myc, Sp1, nuclear factor-?
Transcription (Transcription) of Sp1
3) Confidence 0.41 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0.34 Pain Relevance 0
Sp1 proteins have been shown to bind the LTR constitutively, regardless of the level of transcription [297], and, in the latent stage, Sp1, NF-?
Transcription (level) of Sp1
4) Confidence 0.23 Published 2009 Journal Retrovirology Section Body Doc Link PMC2805609 Disease Relevance 0.25 Pain Relevance 0
Studies have indicated that other transcription factors, such as Sp1, CRE and NF-?
Transcription (transcription) of Sp1
5) Confidence 0.17 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908539 Disease Relevance 0.15 Pain Relevance 0.09
At the level of transcriptional regulation, changes in the levels of cellular binding of the transcription factors Sp-1 and AP-2 to their cognate response DNA sequences contained within the proximal promoter region of the gene of a cartilage matrix component, aggrecan, are indeed the targets of TGF-?
Transcription (transcription) of Sp-1 in proximal
6) Confidence 0.08 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC154434 Disease Relevance 0.27 Pain Relevance 0
Mutant DMPK transcripts bind and sequester transcription factors such as Specificity protein 1 leading to reduced transcription of selected genes.
Transcription (transcription) of Specificity protein 1
7) Confidence 0.03 Published 2008 Journal Current Genomics Section Abstract Doc Link PMC2694559 Disease Relevance 0.13 Pain Relevance 0

General Comments

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