INT173639

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Context Info
Confidence 0.14
First Reported 2003
Last Reported 2011
Negated 1
Speculated 2
Reported most in Body
Documents 40
Total Number 44
Disease Relevance 20.97
Pain Relevance 6.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (INCENP) chromosome segregation (INCENP) chromosome (INCENP)
cytoskeleton (INCENP) nucleus (INCENP) protein complex (INCENP)
Anatomy Link Frequency
urothelial cells 4
synovial fluid 2
brain 2
neutrophil 2
livers 1
INCENP (Homo sapiens)
Pain Link Frequency Relevance Heat
aspirin 110 99.96 Very High Very High Very High
antagonist 67 99.92 Very High Very High Very High
Multiple sclerosis 163 99.56 Very High Very High Very High
cytokine 265 97.88 Very High Very High Very High
Osteoarthritis 121 97.76 Very High Very High Very High
rheumatoid arthritis 77 96.88 Very High Very High Very High
agonist 72 96.88 Very High Very High Very High
dexamethasone 7 96.32 Very High Very High Very High
substance P 70 96.24 Very High Very High Very High
metalloproteinase 39 94.88 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 471 100.00 Very High Very High Very High
Asthma 96 99.92 Very High Very High Very High
Prostate Cancer 21 99.86 Very High Very High Very High
Fibrosis 13 99.84 Very High Very High Very High
Polyploidy 8 99.84 Very High Very High Very High
Drug Induced Neurotoxicity 26 99.80 Very High Very High Very High
Rupture 18 99.66 Very High Very High Very High
Demyelinating Disease 183 99.56 Very High Very High Very High
Stress 146 98.92 Very High Very High Very High
Hepatitis C Virus Infection 378 98.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The results indicate that model-based tracking can measure in-vivo motion of the patella to within 0.455 mm and 0.987°.
Positive_regulation (measure) of in-vivo in patella
1) Confidence 0.14 Published 2008 Journal J Orthop Surg Section Body Doc Link PMC2538511 Disease Relevance 0.21 Pain Relevance 0.28
Although a number of techniques for measuring in-vivo PF joint motion have been previously reported, the accuracy of these techniques is reported far less frequently.
Positive_regulation (measuring) of in-vivo in joint
2) Confidence 0.14 Published 2008 Journal J Orthop Surg Section Body Doc Link PMC2538511 Disease Relevance 0 Pain Relevance 0.04
Although in vitro induction of polyploidy permitted mass production of pure tetraploids, it could also generate mixoploids (i.e., chimeras consisting of diploid and tetraploid cells).
Positive_regulation (induction) of in vitro associated with polyploidy and tetraploidy
3) Confidence 0.09 Published 2010 Journal Pharmacognosy Magazine Section Body Doc Link PMC2881646 Disease Relevance 1.36 Pain Relevance 0.05
This result is a satisfactory proof that our automated in vitro selection process is capable of yielding aptamers with equal, if not better, qualities than reported for manual in vitro selection schemes.
Positive_regulation (automated) of in vitro
4) Confidence 0.08 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC552970 Disease Relevance 0 Pain Relevance 0.16
The induction of capillary leakage in vitro was accomplished after incubation with endotoxin or cytokines for 6 hours [6].
Positive_regulation (induction) of in vitro in capillary associated with cytokine
5) Confidence 0.05 Published 2005 Journal Crit Care Section Body Doc Link PMC1175929 Disease Relevance 0.89 Pain Relevance 0.28
concentrations in these individuals exceeded considerably the threshold levels of 50 pg/ml and 20 pg/ml, respectively, that are necessary to increase permeability significantly in vitro [6].
Positive_regulation (increase) of in vitro
6) Confidence 0.05 Published 2005 Journal Crit Care Section Body Doc Link PMC1175929 Disease Relevance 0.59 Pain Relevance 0.18
Nevertheless, even if IL-1ra levels are increased in the synovial fluid in vivo, it is uncertain if these IL-1ra levels correlate with OA symptoms or disease progression, as the ratio of IL-1ra to IL-1?
Positive_regulation (increased) of in vivo in synovial fluid associated with osteoarthritis and disease progression
7) Confidence 0.04 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911907 Disease Relevance 0.74 Pain Relevance 0.37
Plitidepsin was found to be active, in vitro and in vivo, usually at concentrations as low as in the nanomolar range [18].
Positive_regulation (active) of in vivo
8) Confidence 0.04 Published 2009 Journal Marine Drugs Section Body Doc Link PMC2763111 Disease Relevance 0.35 Pain Relevance 0
In vitro, the human platelets were activated with application of shear stress, 20 µg/ml collagen, 2 mM CaCl2 and 10U thrombin/1 × 109 platelets.
Positive_regulation (activated) of In vitro in platelets associated with stress
9) Confidence 0.04 Published 2010 Journal The Journal of Advanced Prosthodontics Section Abstract Doc Link PMC2984511 Disease Relevance 0.15 Pain Relevance 0.03
Similar to the calf, the pig is also often used in vitro test to measure intradiscal pressure.
Positive_regulation (used) of in vitro
10) Confidence 0.04 Published 2010 Journal J Orthop Surg Res Section Body Doc Link PMC2993665 Disease Relevance 0 Pain Relevance 0
Effects of US on liposomal distribution Based on these in vitro findings, we next studied the ability of US to increase transport in brain tissue in vivo using a cynomolgus monkey model.
Positive_regulation (increase) of in vivo in brain
11) Confidence 0.04 Published 2010 Journal AAPS PharmSciTech Section Body Doc Link PMC2974134 Disease Relevance 0 Pain Relevance 0
The study demonstrates that US is capable of enhancing the permeation of several molecules including BCNU through brain tissue in vitro and increasing the distribution volume of liposomes in the non-human primate brain in vivo.
Positive_regulation (increasing) of in vivo in brain
12) Confidence 0.04 Published 2010 Journal AAPS PharmSciTech Section Body Doc Link PMC2974134 Disease Relevance 0.17 Pain Relevance 0
The in vitro and in vivo aberrant immune activation and neurotoxicity mediated by HCV core protein were amplified in the presence of HIV-1 Vpr protein.
Positive_regulation (activation) of in vivo associated with drug induced neurotoxicity, acquired immune deficiency syndrome or hiv infection and hepatitis c virus infection
13) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943470 Disease Relevance 1.99 Pain Relevance 0.05
Although herniation is often thought to be the result of a mechanically induced rupture, it can only be induced in vitro in healthy discs by mechanical forces larger than those that are ever normally encountered; in most experimental tests, the vertebral body fails rather than the disc [51].
Positive_regulation (induced) of in vitro in vertebral body associated with rupture
14) Confidence 0.03 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC165040 Disease Relevance 0.32 Pain Relevance 0.20
Cell culture and in vitro stimulation
Positive_regulation (stimulation) of in vitro
15) Confidence 0.03 Published 2005 Journal Respir Res Section Body Doc Link PMC1187924 Disease Relevance 0.18 Pain Relevance 0
In vitro, thrombin significantly increases MMP-1, MMP-3, and MMP-9 protein expression in decidual cells and fetal membranes collected from uncomplicated term pregnancies [47-49].
Positive_regulation (increases) of In vitro
16) Confidence 0.03 Published 2010 Journal BMC Pregnancy Childbirth Section Body Doc Link PMC2841774 Disease Relevance 0.60 Pain Relevance 0.26
In conclusion, in the present study we show that at in vitro antiinflammatory concentrations ASA exerts a TGF-?
Positive_regulation (concentrations) of in vitro associated with aspirin and inflammation
17) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2842433 Disease Relevance 0.51 Pain Relevance 0.30
In vivo, increased IL-1ra levels were found in equine synovial fluid 35 days after the last (of four) injections with ACS [14].
Positive_regulation (increased) of In vivo in synovial fluid
18) Confidence 0.03 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911907 Disease Relevance 0.41 Pain Relevance 0.36
However, the permeation enhancing effect of benzalkonium chloride and EDTA combination, observed in the in vitro studies,did not translate into increased ocular availability during in vivo assessment.
Positive_regulation (increased) of in vitro
19) Confidence 0.03 Published 2008 Journal AAPS J Section Body Doc Link PMC2751374 Disease Relevance 0.22 Pain Relevance 0.96
Moreover, we demonstrate that the expression of genes of the RANK/RANK-L pathway could be induced by certain stimuli in neutrophils in vitro.
Positive_regulation (induced) of in vitro in neutrophils
20) Confidence 0.02 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906801 Disease Relevance 0.77 Pain Relevance 0.34

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