INT173641

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Context Info
Confidence 0.39
First Reported 2002
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 13
Total Number 14
Disease Relevance 2.85
Pain Relevance 1.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (MSC) DNA binding (MSC)
Anatomy Link Frequency
joints 1
MSC 1
muscles 1
dopaminergic neurons 1
MSC (Homo sapiens)
Pain Link Frequency Relevance Heat
fibrosis 7 99.84 Very High Very High Very High
dexamethasone 102 98.72 Very High Very High Very High
Arthritis 20 97.88 Very High Very High Very High
Osteoarthritis 25 97.60 Very High Very High Very High
Action potential 2 95.40 Very High Very High Very High
antagonist 26 92.48 High High
cytokine 35 91.68 High High
substance P 15 90.52 High High
Central nervous system 5 88.36 High High
MU agonist 4 83.20 Quite High
Disease Link Frequency Relevance Heat
Fibrosis 6 99.84 Very High Very High Very High
Disease 113 99.16 Very High Very High Very High
Rheumatoid Arthritis 24 97.88 Very High Very High Very High
Osteoarthritis 34 97.60 Very High Very High Very High
Neurodegenerative Disease 12 81.12 Quite High
Hematological Disease 11 79.72 Quite High
Osteoporosis 38 79.60 Quite High
Syndrome 9 77.52 Quite High
Leukemia 3 74.12 Quite High
Injury 45 71.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Three main principles underlie the MSC model.
Regulation (underlie) of MSC
1) Confidence 0.39 Published 2002 Journal Sci Pract Perspect Section Body Doc Link PMC2851064 Disease Relevance 0.06 Pain Relevance 0.19
Some treatment experts have expressed concern that the MSC model relies partly upon the patientÂ’s desire to minimize exposure to counseling to motivate clinical progress.
Regulation (relies) of MSC
2) Confidence 0.39 Published 2002 Journal Sci Pract Perspect Section Body Doc Link PMC2851064 Disease Relevance 0.11 Pain Relevance 0.14
It would appear that the prevalence of MSC affecting muscles and joints needs to be revisited in the next round of BoD estimations.
Regulation (affecting) of MSC in joints associated with disease
3) Confidence 0.35 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2830178 Disease Relevance 0.67 Pain Relevance 0.16
For recalculating the starting number of MSC in the MNC fraction, CFU assays were performed and the MSC frequency was determined.
Regulation (recalculating) of MSC
4) Confidence 0.27 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1829400 Disease Relevance 0 Pain Relevance 0
Differentiation of MSC toward endodermal lineages, including hepatocytes and their therapeutic effect on fibrosis has been described but remains controversial.
Regulation (effect) of MSC in MSC associated with fibrosis
5) Confidence 0.21 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2722022 Disease Relevance 0.36 Pain Relevance 0.05
In conclusion, the neurogenic induction protocol used in this study has no cytotoxic effect on MSC and promotes their differentiation into functional dopaminergic neurons as demonstrated by flow cytometry, RT-PCR, microarray and calcium influx.
Neg (no) Regulation (effect) of MSC in dopaminergic neurons
6) Confidence 0.14 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2358905 Disease Relevance 0.15 Pain Relevance 0.30
It would appear that the prevalence of MSC affecting muscles and joints needs to be revisited in the next round of BoD estimations.
Regulation (affecting) of MSC in muscles associated with disease
7) Confidence 0.12 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2830178 Disease Relevance 0.67 Pain Relevance 0.16
MSC viability was not significantly affected during the brief exposure to serum free conditions and ApoE expression occurred at levels comparable to expression in serum containing media (Figure 7b).
Neg (not) Regulation (affected) of MSC
8) Confidence 0.08 Published 2008 Journal BMC Biotechnol Section Body Doc Link PMC2596794 Disease Relevance 0 Pain Relevance 0.16
As discussed here, the microenvironment plays a very critical role in MSC development.
Regulation (role) of MSC
9) Confidence 0.08 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC154434 Disease Relevance 0 Pain Relevance 0.04
Overall cell recovery was slightly reduced when compared to the untreated controls suggesting that DMSO primarily affected MSC proliferation (data not shown).
Regulation (affected) of MSC
10) Confidence 0.06 Published 2008 Journal BMC Biotechnol Section Body Doc Link PMC2596794 Disease Relevance 0 Pain Relevance 0.19
did not have the same enhancing effect on MSC transdifferentiation as IL-1?.
Regulation (effect) of MSC
11) Confidence 0.06 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727904 Disease Relevance 0.24 Pain Relevance 0.17
Here, we have focused on three ubiquitous microenvironmental factors with known effects on MSC function, and addressed how local delivery of inhibitors to these factors could improve the MSC therapy.



Regulation (effects) of MSC
12) Confidence 0.06 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727904 Disease Relevance 0 Pain Relevance 0.12
A number of signaling pathways have been shown to participate in MSC osteogenesis.
Regulation (participate) of MSC
13) Confidence 0.05 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC154434 Disease Relevance 0.34 Pain Relevance 0.03
The molecular mechanisms of human MSC regulation and the importance of specific growth factors during the different stages of osteogenic differentiation are subjects of intensive investigation.
Regulation (regulation) of MSC
14) Confidence 0.05 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC154434 Disease Relevance 0.26 Pain Relevance 0.11

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