INT173644

Context Info Confidence 0.15 First Reported 2003 Last Reported 2003 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.59 Pain Relevance 0

endoplasmic reticulum (LRP5) plasma membrane (LRP5)

Anatomy Link Frequency osteoblast 2 LRP5 (Homo sapiens)

Pain Link Frequency Relevance Heat dexamethasone 2 11.32 cytokine 4 5.00 Central nervous system 1 5.00 cINOD 1 5.00 rheumatoid arthritis 1 5.00 Osteoarthritis 1 5.00 Pain 1 5.00

Disease Link Frequency Relevance Heat Osteoporosis 8 98.92 Syndrome 3 95.00 Disease 4 85.12 Obesity 7 5.00 Adhesions 5 5.00 Familial Adenomatous Polyposis 4 5.00 Osteoarthritis 4 5.00 Hematological Disease 3 5.00 Focal Cartilage Defect 3 5.00 Aging 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

It has also been shown that mice with targeted disruptions of LRP-5 expression have a decreased level of osteoblast proliferation and display a phenotype similar to humans with osteoporosis–pseudoglioma syndrome [69].

Negative_regulation (disruptions) of Gene_expression (expression) of LRP-5 in osteoblast associated with syndrome and osteoporosis

1) Confidence 0.15 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC154434 Disease Relevance 0.59 Pain Relevance 0

General Comments

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