INT173653

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Context Info
Confidence 0.06
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.77
Pain Relevance 0.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (CDH2) plasma membrane (CDH2)
CDH2 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 8 84.64 Quite High
tolerance 2 50.48 Quite High
antagonist 29 49.92 Quite Low
cytokine 25 5.00 Very Low Very Low Very Low
Pain 7 5.00 Very Low Very Low Very Low
Central nervous system 2 5.00 Very Low Very Low Very Low
analgesia 2 5.00 Very Low Very Low Very Low
dexamethasone 2 5.00 Very Low Very Low Very Low
nociceptor 2 5.00 Very Low Very Low Very Low
Bioavailability 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Skin Cancer 14 92.96 High High
Adhesions 9 91.20 High High
Cancer 244 89.48 High High
Metastasis 20 73.68 Quite High
Cervical Cancer 2 58.00 Quite High
Osteoarthritis 4 55.12 Quite High
Malignant Neoplastic Disease 7 54.00 Quite High
Reprotox - General 1 22 52.32 Quite High
Carcinoma 3 50.00 Quite Low
Familial Adenomatous Polyposis 4 43.52 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
1 led to a transient increase in N-cadherin levels, followed by rapid decrease below basal levels (R Tuli et al., unpublished observation).
Positive_regulation (increase) of N-cadherin
1) Confidence 0.06 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC154434 Disease Relevance 0.20 Pain Relevance 0
-catenin which contributes to loss of E-cadherin function, with a concomitant upregulation of N-cadherin.
Positive_regulation (upregulation) of N-cadherin
2) Confidence 0.05 Published 2004 Journal J Transl Med Section Body Doc Link PMC436068 Disease Relevance 0.74 Pain Relevance 0.16
The EMT program involves the downregulation of epithelial proteins such as E-cadherin and cytokeratins, and the upregulation of mesenchymal proteins including Fibronectin, N-cadherin, and Vimentin.
Positive_regulation (upregulation) of N-cadherin
3) Confidence 0.05 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2840411 Disease Relevance 0.83 Pain Relevance 0.03

General Comments

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