INT173655

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Context Info
Confidence 0.39
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 11
Disease Relevance 3.06
Pain Relevance 0.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (LRP5) plasma membrane (LRP5)
Anatomy Link Frequency
cardiovascular system 1
LRP5 (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 16 86.04 High High
headache 6 70.16 Quite High
backache 7 54.32 Quite High
dexamethasone 2 42.48 Quite Low
depression 29 5.00 Very Low Very Low Very Low
Kinase C 19 5.00 Very Low Very Low Very Low
cINOD 18 5.00 Very Low Very Low Very Low
agonist 13 5.00 Very Low Very Low Very Low
alcohol 12 5.00 Very Low Very Low Very Low
tetrodotoxin 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoporosis 8 99.84 Very High Very High Very High
Disease 97 99.76 Very High Very High Very High
Syndrome 3 98.80 Very High Very High Very High
Poisoning 103 97.72 Very High Very High Very High
Obesity 28 96.08 Very High Very High Very High
Toxicity 13 90.68 High High
Mental Disorders 81 86.96 High High
Vomiting 6 72.20 Quite High
Fatigue 7 71.04 Quite High
Dizziness 6 70.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Employees can not be randomly assigned to OPs trained in the intervention or OPs not trained in the intervention because the OPs and employees are bound to each other by the company.
OPs Binding (bound) of
1) Confidence 0.39 Published 2010 Journal BMC Public Health Section Body Doc Link PMC2841673 Disease Relevance 0.09 Pain Relevance 0
Since LRP5/6 encodes a co-receptor for the Wnt pathway, its association with AD was studied.
LRP5 Binding (association) of associated with disease
2) Confidence 0.35 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2515306 Disease Relevance 1.12 Pain Relevance 0
Recruitment of OPs takes place in collaboration with ArboNed, one of the largest Occupational Health Services (OHS) in the Netherlands.
OPs Binding (Recruitment) of
3) Confidence 0.30 Published 2010 Journal BMC Public Health Section Body Doc Link PMC2841673 Disease Relevance 0 Pain Relevance 0
The second group, consisting of the Dickkopf (DKK) family, inhibits Wnt signaling by binding to the LRP5/LRP6 component of the Wnt receptor complex [8].
LRP5 Binding (binding) of
4) Confidence 0.14 Published 2006 Journal Invest New Drugs Section Body Doc Link PMC2780666 Disease Relevance 0.06 Pain Relevance 0.04
An established Wnt coreceptor, the low-density lipoprotein receptor-related peptide5 (LRP-5) has been linked to osteoporosis–pseudoglioma syndrome in humans [68].
lipoprotein receptor-related peptide5 Binding (linked) of associated with syndrome and osteoporosis
5) Confidence 0.11 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC154434 Disease Relevance 0.42 Pain Relevance 0
Comparing the group who has been spraying with OPs with the group who has not, controlling for the number of protective behaviors performed and the BMI, a mean ChE activity of 7.11 kU/L for those who have sprayed with OPs compared to a mean ChE of 8.03 kU/L for those who have not, was found (p < 0.01).
OPs Binding (spraying) of associated with obesity
6) Confidence 0.11 Published 2006 Journal Environ Health Section Body Doc Link PMC1464129 Disease Relevance 0.40 Pain Relevance 0
Possible symptoms of intoxications and a depressed ChE activity after spraying sessions seemed to be common and were related to spraying intensity, spraying with OPs or not and the number of protective behaviors performed when handling pesticides.
OPs Binding (spraying) of associated with poisoning
7) Confidence 0.11 Published 2006 Journal Environ Health Section Body Doc Link PMC1464129 Disease Relevance 0.29 Pain Relevance 0
Analyzing for the use of OPs or pesticides other than OPs and controlling for the number of protective behaviors practiced, an OR of 2.96 (95% CI 0.96-9.12) for having symptoms after spraying with OPs was found.
OPs Binding (spraying) of
8) Confidence 0.11 Published 2006 Journal Environ Health Section Body Doc Link PMC1464129 Disease Relevance 0.35 Pain Relevance 0.07
Likewise, there is multiple evidence that OPs can interact with targets other than AChE in the cardiovascular system [25, 26].
OPs Binding (interact) of in cardiovascular system
9) Confidence 0.06 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2859412 Disease Relevance 0.08 Pain Relevance 0
It has been shown that OPs could interact directly with targets other than acetylcholinesterase [20, 21].
OPs Binding (interact) of
10) Confidence 0.06 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2859412 Disease Relevance 0.09 Pain Relevance 0
Recruitment of OPs
OPs Binding (Recruitment) of
11) Confidence 0.02 Published 2008 Journal BMC Health Serv Res Section Body Doc Link PMC2390533 Disease Relevance 0.17 Pain Relevance 0.11

General Comments

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