INT173693

Context Info Confidence 0.65 First Reported 2003 Last Reported 2010 Negated 13 Speculated 4 Reported most in Body Documents 249 Total Number 253 Disease Relevance 70.49 Pain Relevance 38.81

transport (Gopc) Golgi apparatus (Gopc) plasma membrane (Gopc) cytoplasm (Gopc)

Anatomy Link Frequency neurons 12 nucleus 6 muscle 4 plasma 4 epithelial cells 4 Gopc (Mus musculus)

Pain Link Frequency Relevance Heat Inflammation 1204 100.00 Morphine 807 100.00 Dopamine 497 100.00 Kinase C 363 100.00 gABA 304 100.00 Action potential 253 100.00 Glutamate 247 100.00 metalloproteinase 223 100.00 adenocard 219 100.00 tolerance 182 100.00

Disease Link Frequency Relevance Heat Cancer 1907 100.00 INFLAMMATION 1489 100.00 Targeted Disruption 877 100.00 Disease 682 100.00 Injury 613 100.00 Death 317 100.00 Disorder Of Lipid Metabolism 282 100.00 Aids-related Complex 180 100.00 Body Weight 122 100.00 Alzheimer's Dementia 72 100.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The mice used in this experiment were previously evaluated for SI and SCPP (see Fig. 10 and below), and these individuals were the only mice that were assessed behaviorally more than once.

Localization (see) of Fig

1) Confidence 0.65 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2633046 Disease Relevance 0.15 Pain Relevance 0

Na131I SPECT/CT fusion images shown in Fig. 5A (coronal image) and B (sagittal image) clearly displayed the mouse bone anatomic structure (brown-red color) and the localization of the probe in the thyroid and abdomen region (green color, thyroid was indicated by an arrow).

Localization (localization) of Fig in thyroid

2) Confidence 0.62 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2830426 Disease Relevance 0.21 Pain Relevance 0.70

We quantified the incidence of sprouts and AChR clusters after BoNT/A intoxication in order to relate their appearance to the onset of evoked quantal release (Fig. 3B).

Localization (release) of Fig associated with poisoning

3) Confidence 0.61 Published 2008 Journal The Journal of Physiology Section Body Doc Link PMC2538785 Disease Relevance 0.32 Pain Relevance 0.08

In neurons, which displayed an inhibitory response to 5-HT there was a rapid hyperpolarization (Fig. 1A) from a mean membrane potential of ?

Localization (hyperpolarization) of Fig in neurons

4) Confidence 0.57 Published 2009 Journal Neuroscience Section Body Doc Link PMC2661429 Disease Relevance 0 Pain Relevance 0.12

Both the extracellular (left column of Fig. 3C) and the voltage-sensitive dye data (middle column of Fig. 3C) showed single minima at very similar locations of 14 and 13 ?

Localization (column) of Fig

5) Confidence 0.57 Published 2010 Journal The Journal of Physiology Section Body Doc Link PMC2887989 Disease Relevance 0 Pain Relevance 0.07

Both the extracellular (left column of Fig. 3C) and the voltage-sensitive dye data (middle column of Fig. 3C) showed single minima at very similar locations of 14 and 13 ?

Localization (column) of Fig

6) Confidence 0.57 Published 2010 Journal The Journal of Physiology Section Body Doc Link PMC2887989 Disease Relevance 0 Pain Relevance 0.07

Whole body in vivo fluorescent imaging showed that the B cells in all test groups were predominantly localized within the spleen one day after delivery (Fig. 3A).

Localization (localized) of Fig in spleen associated with imagery

7) Confidence 0.54 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2871797 Disease Relevance 0 Pain Relevance 0.25

Two-pathway stimulation experiments (Fig. 5) have confirmed that increase of proximal fEPSPs, as a result of LTP, was specific to the tetanised pathway and did not reflect a generalised heterosynaptic enhancement of post-synaptic excitability.

Localization (result) of Fig in proximal associated with long-term potentiation

8) Confidence 0.52 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1574331 Disease Relevance 0 Pain Relevance 0.49

9) in dopamine releasing and responding regions (Fig. 5, p<0.05), as well as additional regions (Table 2, p<0.05).

Localization (releasing) of Fig associated with dopamine

9) Confidence 0.49 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2276864 Disease Relevance 0 Pain Relevance 0.11

Our results of ex vivo fluorescence imaging showed that the 2-DG dye distributed well into the whole tumor despite some heterogeneity (Fig. 5).

Localization (distributed) of Fig associated with cancer and imagery

10) Confidence 0.49 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2778127 Disease Relevance 1.03 Pain Relevance 0.20

In addition, neurofascin-186 and Nav1.6 channels are localized to nodes of Ranvier (Fig. 4, e, f, i, and j) and caspr, and neurofascin-155 and band 4.1 are appropriately localized at paranodes (Fig. 4, k–n).

Localization (localized) of Fig in nodes associated with nav1.6

11) Confidence 0.47 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2592840 Disease Relevance 0 Pain Relevance 0.26

In fact, the GFP-expressing tumor was sufficiently bright to enable its instant localization (Fig. 5).

Localization (localization) of Fig associated with cancer

12) Confidence 0.46 Published 2010 Journal Surg Endosc Section Body Doc Link PMC3003784 Disease Relevance 0.53 Pain Relevance 0

SA currents, which are present in around 30% of all nociceptors (Hu & Lewin, 2006; Lechner et al. 2009), were not affected by application of UTP (Fig. 2A and B).

Localization (application) of Fig in nociceptors associated with nociceptor

13) Confidence 0.45 Published 2009 Journal The Journal of Physiology Section Body Doc Link PMC2742277 Disease Relevance 0.46 Pain Relevance 0.51

The same cell was superfused with UTP and sub-threshold stimuli (threshold-1 step, -2 steps, etc.) were tested for their ability to evoke an AP (Fig. 4A).

Localization (evoke) of Fig associated with action potential

14) Confidence 0.45 Published 2009 Journal The Journal of Physiology Section Body Doc Link PMC2742277 Disease Relevance 0.34 Pain Relevance 0.53

RA currents recorded in mechanoreceptors, which are pharmacologically indistinguishable from RA currents in nociceptors (Hu & Lewin, 2006), were not potentiated by UTP (Fig. 1B).

Neg (not) Localization (potentiated) of Fig in nociceptors associated with nociceptor and rheumatoid arthritis

15) Confidence 0.45 Published 2009 Journal The Journal of Physiology Section Body Doc Link PMC2742277 Disease Relevance 0.49 Pain Relevance 0.49

APs generated from the TJM and the DCM under most conditions used in Fig. 6 (A–C) are shown for 0.6- (Fig. 6 D) and 4.0-?

Localization (generated) of Fig

16) Confidence 0.44 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2592840 Disease Relevance 0 Pain Relevance 0.03

The highest density of L1 immunoreactive fibres was localized in the stria terminalis (Fig. 2a,2a',6c,6d).

Localization (localized) of Fig

17) Confidence 0.44 Published 2003 Journal BMC Neurosci Section Body Doc Link PMC155647 Disease Relevance 0 Pain Relevance 0.10

Both fresh (Fig. 4A) and hyperactivated (Fig. 6B) sperm showed substantial acceleration of the flagellar beat when HCO3?

Localization (fresh) of Fig in sperm

18) Confidence 0.43 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2729922 Disease Relevance 0 Pain Relevance 0

Both fresh (Fig. 4A) and hyperactivated (Fig. 6B) sperm showed substantial acceleration of the flagellar beat when HCO3?

Localization (fresh) of Fig in sperm

19) Confidence 0.43 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2729922 Disease Relevance 0 Pain Relevance 0

This heat-induced ATP release was significantly reduced by ruthenium red (RR, 50 µM), a broad TRP channel inhibitor (Fig. 6, red) at higher temperature range: in the presence of ruthenium red, the RR-insensitive ATP release activated at lower temperature range (>?

Localization (release) of Fig associated with trp channel

20) Confidence 0.43 Published 2009 Journal Pflugers Arch Section Body Doc Link PMC2745623 Disease Relevance 0.19 Pain Relevance 0.14

General Comments

This test has worked.