INT17370

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Context Info
Confidence 0.22
First Reported 1982
Last Reported 2005
Negated 1
Speculated 0
Reported most in Abstract
Documents 16
Total Number 16
Disease Relevance 6.50
Pain Relevance 6.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear envelope (Ptgs1) aging (Ptgs1) Golgi apparatus (Ptgs1)
endoplasmic reticulum (Ptgs1) cytoplasm (Ptgs1) lipid binding (Ptgs1)
Anatomy Link Frequency
egg 6
platelet 4
neuronal 2
liver 2
spinal cord 2
Ptgs1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal cord 5 100.00 Very High Very High Very High
cINOD 17 99.96 Very High Very High Very High
Perioperative pain 2 99.84 Very High Very High Very High
COX2 2 99.84 Very High Very High Very High
cOX1 1 99.84 Very High Very High Very High
Pain 1 99.80 Very High Very High Very High
neuropeptide release 3 99.16 Very High Very High Very High
tetrodotoxin 3 98.80 Very High Very High Very High
aspirin 11 98.78 Very High Very High Very High
cva 4 97.64 Very High Very High Very High
Disease Link Frequency Relevance Heat
Burns 5 99.84 Very High Very High Very High
INFLAMMATION 37 99.68 Very High Very High Very High
Pain 2 99.28 Very High Very High Very High
Hepatotoxicity 1 98.72 Very High Very High Very High
Adhesions 1 98.08 Very High Very High Very High
Cv General 3 Under Development 2 97.64 Very High Very High Very High
Myocardial Infarction 2 96.52 Very High Very High Very High
Rheumatoid Arthritis 2 95.60 Very High Very High Very High
Stroke 1 95.48 Very High Very High Very High
Airway Obstruction 1 95.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Inhibitors of thromboxane synthesis such as the cyclooxygenase inhibitor, indomethacin, the thromboxane synthase blocker, 1-benzylimidazole, or the combined cyclooxygenase/lipoxygenase/thromboxane synthase inhibitor, sulfasalazine, inhibited the contraction evoked by egg albumin.
Negative_regulation (inhibitor) of Negative_regulation (inhibitor) of cyclooxygenase in egg
1) Confidence 0.22 Published 1997 Journal Zentralbl Veterinarmed A Section Abstract Doc Link 9342927 Disease Relevance 0 Pain Relevance 0.14
Inhibitors of thromboxane synthesis such as the cyclooxygenase inhibitor, indomethacin, the thromboxane synthase blocker, 1-benzylimidazole, or the combined cyclooxygenase/lipoxygenase/thromboxane synthase inhibitor, sulfasalazine, inhibited the contraction evoked by egg albumin.
Negative_regulation (Inhibitors) of Negative_regulation (inhibitor) of cyclooxygenase in egg
2) Confidence 0.22 Published 1997 Journal Zentralbl Veterinarmed A Section Abstract Doc Link 9342927 Disease Relevance 0 Pain Relevance 0.14
Inhibitors of thromboxane synthesis such as the cyclooxygenase inhibitor, indomethacin, the thromboxane synthase blocker, 1-benzylimidazole, or the combined cyclooxygenase/lipoxygenase/thromboxane synthase inhibitor, sulfasalazine, inhibited the contraction evoked by egg albumin.
Negative_regulation (Inhibitors) of Negative_regulation (inhibitor) of cyclooxygenase in egg
3) Confidence 0.22 Published 1997 Journal Zentralbl Veterinarmed A Section Abstract Doc Link 9342927 Disease Relevance 0 Pain Relevance 0.13
[Antiphlogistic effectiveness of combinations of inhibitors of phospholipase A2, cyclooxygenase and lipoxygenases of the arachidonic acid cascade].
Negative_regulation (effectiveness) of Negative_regulation (inhibitors) of cyclooxygenase
4) Confidence 0.22 Published 1986 Journal Pharmazie Section Title Doc Link 3088612 Disease Relevance 0.42 Pain Relevance 0.35
Cyclooxygenase inhibition with indomethacin partially reversed bombesin and mild irritant-induced gastroprotection but did not diminish the protective actions of L-DOPA.
Negative_regulation (reversed) of Negative_regulation (inhibition) of Cyclooxygenase
5) Confidence 0.19 Published 1998 Journal Surgery Section Body Doc Link 9823400 Disease Relevance 0 Pain Relevance 0
Aspirin and nonaspirin nonsteroidal antiinflammatory drugs (NSAIDs) inhibit platelet cyclooxygenase, thereby blocking the formation of thromboxane A2.
Negative_regulation (blocking) of Negative_regulation (inhibit) of cyclooxygenase in platelet associated with aspirin, inflammation and cinod
6) Confidence 0.19 Published 1995 Journal J Clin Pharmacol Section Abstract Doc Link 7608308 Disease Relevance 0.41 Pain Relevance 0.37
These results suggest that inhibition of cyclooxygenase at the level of the spinal cord attenuates the augmentation of neuropeptide release induced by peripheral inflammation, and provide further evidence for an action of prostaglandins at central terminals of sensory neurons during inflammation.
Negative_regulation (attenuates) of Negative_regulation (inhibition) of cyclooxygenase in spinal cord associated with inflammation, neuropeptide release and spinal cord
7) Confidence 0.18 Published 1998 Journal Pain Section Abstract Doc Link 9822210 Disease Relevance 0.82 Pain Relevance 1.29
Protective role of cyclooxygenase (COX) inhibitors in burn-induced intestinal and liver damage.
Negative_regulation (role) of Negative_regulation (inhibitors) of cyclooxygenase in liver associated with burns and hepatotoxicity
8) Confidence 0.17 Published 2002 Journal Burns Section Title Doc Link 11996850 Disease Relevance 0.54 Pain Relevance 0.06
One supposes that PG are proinflammatory, explaining why nonsteroidal antiinflammatory drugs (NSAID), which prevent conversion of arachidonic acid to stable PG through cyclooxygenase inhibition, exert their antiinflammatory effects.
Negative_regulation (prevent) of Negative_regulation (inhibition) of cyclooxygenase associated with inflammation and cinod
9) Confidence 0.10 Published 1991 Journal J Rheumatol Suppl Section Abstract Doc Link 1903811 Disease Relevance 0.91 Pain Relevance 0.38
Muscarinic blockade with 10(-6)M atropine and cyclooxygenase inhibition by 10(-6)M indomethacin attenuated the constrictor response to fentanyl.
Negative_regulation (blockade) of Negative_regulation (inhibition) of cyclooxygenase
10) Confidence 0.03 Published 1995 Journal Life Sci. Section Abstract Doc Link 8614244 Disease Relevance 0 Pain Relevance 0.65
As our data indicate, this basal adhesion, which is observed in the absence of exogenous chemotactic agents or other stimuli, is neither dependent upon endogenous cyclooxygenase derivatives of arachidonate, nor inhibited by exogenous prostacyclin.
Neg (neither) Negative_regulation (dependent) of Negative_regulation (derivatives) of endogenous cyclooxygenase associated with adhesions
11) Confidence 0.03 Published 1982 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 6820246 Disease Relevance 0.44 Pain Relevance 0.13
Kallidin transiently increased I(sc), an effect reduced after inhibition of neuronal conduction by 0.1 microM saxitoxin, cyclooxygenase inhibition by 10 microM indomethacin, or kinin B(2) receptor blockade by 1 microM d-arginyl-l-arginyl-l-prolyl-trans-4-hydroxy-l-prolylglycyl-3-(2-thienyl)-l-alanyl-l-seryl-d-1,2,3,4-tetrahydro-3-isoquinolinecarbonyl-l-(2alpha,3beta,7alphabeta)-octahydro-1H-indole-2-carbonyl-l-arginine (HOE-140).
Negative_regulation (inhibition) of Negative_regulation (inhibition) of cyclooxygenase in neuronal
12) Confidence 0.01 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12606641 Disease Relevance 0 Pain Relevance 0.28
Nonsteroidal anti-inflammatory drugs (NSAIDs) inhibit cyclooxygenase-1 (COX-1), thereby inhibiting platelet function via blockade of thromboxane A2 (TxA2) formation, and COX-2, the enzyme that mediates inflammatory responses.
Negative_regulation (inhibiting) of Negative_regulation (inhibit) of cyclooxygenase-1 in platelet associated with inflammatory response, inflammation and cinod
13) Confidence 0.01 Published 2002 Journal J Clin Pharmacol Section Abstract Doc Link 12162470 Disease Relevance 0.34 Pain Relevance 0.37
[Critical reevaluation of cyclooxygenase two inhibitors in perioperative pain therapy].
Negative_regulation (reevaluation) of Negative_regulation (inhibitors) of cyclooxygenase associated with pain and perioperative pain
14) Confidence 0.01 Published 2005 Journal Anaesthesist Section Title Doc Link 16132939 Disease Relevance 1.04 Pain Relevance 0.67
There was no significant decrease in serum TXB2 levels, indicating the absence of cyclooxygenase inhibition with CMT.
Negative_regulation (absence) of Negative_regulation (inhibition) of cyclooxygenase
15) Confidence 0.01 Published 1990 Journal Eur. Respir. J. Section Abstract Doc Link 2198165 Disease Relevance 0.67 Pain Relevance 0.45
[Recent development of selective cyclooxygenase-2 inhibitors].
Negative_regulation (development) of Negative_regulation (inhibitors) of cyclooxygenase associated with cox1
16) Confidence 0.01 Published 2002 Journal Nippon Rinsho Section Title Doc Link 12510364 Disease Relevance 0.90 Pain Relevance 0.71

General Comments

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