INT173716

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Context Info
Confidence 0.44
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 8
Disease Relevance 4.65
Pain Relevance 1.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Cd44) plasma membrane (Cd44) nucleus (Cd44)
protein complex (Cd44)
Anatomy Link Frequency
Notch 1
plasma 1
leukocytes 1
oligodendrocyte 1
Cd44 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammatory response 23 99.40 Very High Very High Very High
Inflammation 126 99.22 Very High Very High Very High
fibrosis 28 90.80 High High
cytokine 58 89.20 High High
chemokine 28 85.96 High High
Crohn's disease 1 67.08 Quite High
Arthritis 2 66.40 Quite High
Inflammatory marker 3 55.44 Quite High
Osteoarthritis 1 50.00 Quite Low
Inflammatory mediators 2 28.28 Quite Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 174 99.84 Very High Very High Very High
INFLAMMATION 155 99.22 Very High Very High Very High
Apoptosis 44 93.50 High High
Stress 12 93.28 High High
Injury 86 92.72 High High
Rheumatoid Arthritis 1 91.08 High High
Fibrosis 30 90.80 High High
Keloid Scars 1 86.32 High High
Diabetic Retinopathy 96 82.96 Quite High
Disease 15 82.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We showed that MIF, CD44 and CD74 are all upregulated in the urothelium after experimental inflammation in rats [6], [17].
Positive_regulation (upregulated) of CD44 associated with inflammation
1) Confidence 0.44 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2588654 Disease Relevance 0.94 Pain Relevance 0.46
Previous studies of these genes, including markers of toxic stress, apoptosis, growth regulation and repair, were consistent with documented toxicologic responses to CCl4, where expression of components of cytochrome P450 and other metabolic enzymes (Cyp2C, Cyp3A18, Cyp3A9, SCS and Fmo1) were found to decrease, whereas certain genes involved in the inflammatory response and signal transduction were increased (CD44 and Lgals3) [7].
Positive_regulation (increased) of CD44 associated with stress, inflammatory response and apoptosis
2) Confidence 0.37 Published 2003 Journal Genome Biol Section Body Doc Link PMC156588 Disease Relevance 0.35 Pain Relevance 0.05
Of the 15 inflammatory genes tested, 12 genes (C1-INH, CCR5, CD44, CHI3L1, HSPB1, JAK3, LGALS3, LGALS3BP, LAMA5, PEDF, STAT3, TIMP1) were reproducibly upregulated at 3 months (Figures 4 &5).
Positive_regulation (upregulated) of CD44 associated with inflammation
3) Confidence 0.32 Published 2008 Journal BMC Med Genomics Section Body Doc Link PMC2442612 Disease Relevance 0.33 Pain Relevance 0.12
The systemic plasma levels of the primary ligand for CD44, hyaluronan, are increased in diabetic patients [35].
Positive_regulation (increased) of CD44 in plasma associated with diabetes mellitus
4) Confidence 0.32 Published 2008 Journal BMC Med Genomics Section Body Doc Link PMC2442612 Disease Relevance 0.81 Pain Relevance 0.21
In a manner similar to CCR5, increased CD44 levels could work synergistically with elevated levels of its ligand to recruit leukocytes.
Positive_regulation (increased) of CD44 in leukocytes
5) Confidence 0.32 Published 2008 Journal BMC Med Genomics Section Body Doc Link PMC2442612 Disease Relevance 0.86 Pain Relevance 0.24
Immunohistology revealed increases in CTGF, CD44 and iNOS 6 months after meniscectomy.
Positive_regulation (increases) of CD44
6) Confidence 0.14 Published 2008 Journal Rheumatology (Oxford, England) Section Body Doc Link PMC2468886 Disease Relevance 0.93 Pain Relevance 0.33
Other growth factors, including Notch, FGF and BMP family members and their corresponding receptors, as well as the cell surface glycoprotein CD44 were also increased on the SuperArray, however, changes in their expression levels remain to be validated (Table S1).


Positive_regulation (increased) of CD44 in Notch
7) Confidence 0.13 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2832687 Disease Relevance 0.07 Pain Relevance 0.04
Our SuperArray results indicate an up-regulation of CD44 in the injured SVZ, the cell surface glycoprotein capable of binding hyaluronic acid, supporting a potential role for hylauronan as an inhibitor of oligodendrocyte production after injury.
Positive_regulation (up-regulation) of CD44 in oligodendrocyte associated with injury
8) Confidence 0.12 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2832687 Disease Relevance 0.36 Pain Relevance 0

General Comments

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