INT173717

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Context Info
Confidence 0.65
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 22
Total Number 37
Disease Relevance 13.98
Pain Relevance 1.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ccl4) extracellular region (Ccl4)
Anatomy Link Frequency
liver 7
hepatocytes 2
kidney 1
Ccl4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
fibrosis 123 99.20 Very High Very High Very High
alcohol 81 98.72 Very High Very High Very High
Inflammatory mediators 2 98.72 Very High Very High Very High
cytokine 59 98.48 Very High Very High Very High
Inflammation 118 98.08 Very High Very High Very High
ischemia 16 94.64 High High
Inflammatory response 3 93.48 High High
depression 16 89.96 High High
Pain 17 40.56 Quite Low
Bile 1 24.76 Low Low
Disease Link Frequency Relevance Heat
Liver Disease 46 100.00 Very High Very High Very High
Body Weight 266 99.68 Very High Very High Very High
Cirrhosis 134 99.64 Very High Very High Very High
Apoptosis 21 99.64 Very High Very High Very High
Injury 462 99.60 Very High Very High Very High
Toxicity 51 99.08 Very High Very High Very High
INFLAMMATION 123 98.72 Very High Very High Very High
Stress 52 98.00 Very High Very High Very High
Hepatotoxicity 175 97.92 Very High Very High Very High
Renal Disease 5 97.48 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pretreatment of rats with the Dh root extract (single and multiple dose) reversed the changes produced by CCl4.
Gene_expression (produced) of CCl4
1) Confidence 0.65 Published 2010 Journal Journal of Pharmacy and Bioallied Sciences Section Body Doc Link PMC2996063 Disease Relevance 0.33 Pain Relevance 0.03
The results obtained in this study showed that CCl4 injection produced a significant increase in serum total LDH activity.
Gene_expression (injection) of CCl4
2) Confidence 0.64 Published 2010 Journal Scientia Pharmaceutica Section Body Doc Link PMC3007612 Disease Relevance 0.27 Pain Relevance 0
This study is in accordance with the above mentioned results and shows that CCl4 injection produced a significant decrease in hepatic glutathione content, L-carnitine and coenzyme Q10 significantly increased hepatic glutathione content
Gene_expression (injection) of CCl4
3) Confidence 0.64 Published 2010 Journal Scientia Pharmaceutica Section Body Doc Link PMC3007612 Disease Relevance 0.25 Pain Relevance 0.04
Mitcheva et al. [31] reported that CCl4 injection leads to a significant increase in LDH leakage from rat hepatocytes.
Gene_expression (injection) of CCl4 in hepatocytes
4) Confidence 0.64 Published 2010 Journal Scientia Pharmaceutica Section Body Doc Link PMC3007612 Disease Relevance 0.15 Pain Relevance 0
A significant increase in the levels of ASAT, ALAT, ALP, total bilirubin, LDH (P < 0.001) and a significant reduction in the levels of TGL, total proteins, and albumin (P < 0.001) were observed in hepatocytes exposed to CCl4 when compared to normal rats.
Gene_expression (exposed) of CCl4 in hepatocytes
5) Confidence 0.58 Published 2010 Journal Indian Journal of Pharmacology Section Body Doc Link PMC2907024 Disease Relevance 0 Pain Relevance 0
Effect on the glutathione levels in CCl4 treated rats
Gene_expression (levels) of CCl4
6) Confidence 0.58 Published 2005 Journal BMC Pharmacol Section Body Doc Link PMC549532 Disease Relevance 0.21 Pain Relevance 0
However, the hepatic LPO and GSH concentrations in the CCl4-intoxicated group post-administered with octacosanol (100 mg/kg BW) were not significantly different from those in the CCl4-intoxicated group found at the time point of the alcohol administration (Fig. 2).
Gene_expression (group) of CCl4-intoxicated associated with body weight and alcohol
7) Confidence 0.57 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2266062 Disease Relevance 0.68 Pain Relevance 0.08
The hepatic SOD activity in the CCl4-intoxicated rats given octacosanol (100 mg/kg BW) was almost equal to that in CCl4-intoxicated rats found at the time point of the alcohol administration.
Gene_expression (rats) of CCl4-intoxicated associated with body weight and alcohol
8) Confidence 0.57 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2266062 Disease Relevance 0.94 Pain Relevance 0.05
In CCl4-intoxicated rats, a significant increase in hepatic LPO concentration and a significant decrease in hepatic GSH concentration occurred 6 and 24 h after intoxication and these changes were larger at 24 h than at 6 h (p<0.05) (Fig. 2).
Gene_expression (rats) of CCl4-intoxicated associated with poisoning
9) Confidence 0.57 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2266062 Disease Relevance 0.76 Pain Relevance 0.05
The LPO and GSH concentrations in CCl4-intoxicated rats given octacosanol (100 mg/kg BW) were almost equal to those in CCl4-intoxicated rats found at the time point of the alcohol administration.
Gene_expression (rats) of CCl4-intoxicated associated with body weight and alcohol
10) Confidence 0.57 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2266062 Disease Relevance 1.02 Pain Relevance 0.08
The hepatic SOD activity in the CCl4-intoxicated rats given octacosanol (100 mg/kg BW) was almost equal to that in CCl4-intoxicated rats found at the time point of the alcohol administration.
Gene_expression (activity) of CCl4-intoxicated associated with body weight and alcohol
11) Confidence 0.57 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2266062 Disease Relevance 0.88 Pain Relevance 0.05
and hydroxyl radical, contributes to not only the formation but also the progression of CCl4-induced acute liver injury in rats [6–14].
Gene_expression (progression) of CCl4 in liver associated with injury
12) Confidence 0.57 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2266062 Disease Relevance 0.43 Pain Relevance 0
When the same doses of octacosanol (50 or 100 mg/kg BW) were given to CCl4-untreated rats, both a significant decrease in LPO concentration and a significant increase in GSH concentration were found in the liver tissue (Fig. 2).
Gene_expression (rats) of CCl4-untreated in liver associated with body weight
13) Confidence 0.57 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2266062 Disease Relevance 0.69 Pain Relevance 0.08
Administration of L-carnitine or/and coenzyme Q10 (prior to CCl4 injection) significantly decreased hepatic total LDH activity compared to CCl4 control group as shown in Table 3.
Gene_expression (injection) of CCl4
14) Confidence 0.56 Published 2010 Journal Scientia Pharmaceutica Section Body Doc Link PMC3007612 Disease Relevance 0 Pain Relevance 0
Fig. 3A. shows the electrophoretic separation pattern of hepatic lactate dehydrogenase isoenzymes in normal and CCL4 groups.
Gene_expression (groups) of CCL4
15) Confidence 0.56 Published 2010 Journal Scientia Pharmaceutica Section Body Doc Link PMC3007612 Disease Relevance 0.06 Pain Relevance 0
Treatment with a combination of L-carnitine and coenzyme Q10 (prior to CCl4 injection) resulted in a significant increase in isoenzyme 4 and a significant decrease in isoenzyme 1, isoenzyme 2, isoenzyme 3 and isoenzyme 5.
Gene_expression (injection) of CCl4
16) Confidence 0.56 Published 2010 Journal Scientia Pharmaceutica Section Body Doc Link PMC3007612 Disease Relevance 0.22 Pain Relevance 0.04
L-carnitine (50 mg/kg/day) was given i.p. for four successive days 24 hours before CCl4 injection, and CoQ10 (200 mg/kg) was given as a single i.p. dose 24 hours before CCl4 injection.
Gene_expression (injection) of CCl4
17) Confidence 0.56 Published 2010 Journal Scientia Pharmaceutica Section Abstract Doc Link PMC3007612 Disease Relevance 0.33 Pain Relevance 0
In this study, CCl4 injection produced a significant increase in liver LPO level (expressed in terms of malondialdehyde).
Gene_expression (injection) of CCl4 in liver
18) Confidence 0.56 Published 2010 Journal Scientia Pharmaceutica Section Body Doc Link PMC3007612 Disease Relevance 0.30 Pain Relevance 0.04
The obtained data revealed that CCl4 injection produced a significant decrease in reduced glutathione content, vitamin C, total protein and albumin levels.
Gene_expression (injection) of CCl4
19) Confidence 0.56 Published 2010 Journal Scientia Pharmaceutica Section Abstract Doc Link PMC3007612 Disease Relevance 0.28 Pain Relevance 0
L-carnitine or/and coenzyme Q10 (prior to CCl4 injection) significantly decreased hepatic LPO level.
Gene_expression (injection) of CCl4
20) Confidence 0.56 Published 2010 Journal Scientia Pharmaceutica Section Body Doc Link PMC3007612 Disease Relevance 0.28 Pain Relevance 0.04

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