INT173721

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Context Info
Confidence 0.32
First Reported 2003
Last Reported 2003
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.42
Pain Relevance 0.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Cyp3a18)
Cyp3a18 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammatory response 1 98.40 Very High Very High Very High
cytokine 5 5.00 Very Low Very Low Very Low
Inflammation 3 5.00 Very Low Very Low Very Low
potassium channel 1 5.00 Very Low Very Low Very Low
Paracetamol 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 4 98.40 Very High Very High Very High
Apoptosis 1 97.98 Very High Very High Very High
Stress 2 97.76 Very High Very High Very High
Necrosis 4 71.28 Quite High
Toxicity 14 58.20 Quite High
Hepatotoxicity 1 49.00 Quite Low
Injury 6 5.00 Very Low Very Low Very Low
Cancer 3 5.00 Very Low Very Low Very Low
Hyperplasia 2 5.00 Very Low Very Low Very Low
Exsanguination 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Previous studies of these genes, including markers of toxic stress, apoptosis, growth regulation and repair, were consistent with documented toxicologic responses to CCl4, where expression of components of cytochrome P450 and other metabolic enzymes (Cyp2C, Cyp3A18, Cyp3A9, SCS and Fmo1) were found to decrease, whereas certain genes involved in the inflammatory response and signal transduction were increased (CD44 and Lgals3) [7].
Negative_regulation (decrease) of Gene_expression (expression) of Cyp3A18 associated with stress, inflammatory response and apoptosis
1) Confidence 0.32 Published 2003 Journal Genome Biol Section Body Doc Link PMC156588 Disease Relevance 0.42 Pain Relevance 0.05

General Comments

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