INT173744

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Context Info
Confidence 0.43
First Reported 2003
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 10
Total Number 11
Disease Relevance 7.05
Pain Relevance 0.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

enzyme binding (Esr1) DNA binding (Esr1) protein complex (Esr1)
cytoplasm (Esr1) lipid binding (Esr1) nucleus (Esr1)
Anatomy Link Frequency
embryos 2
leaflet 2
microglial cells 2
Esr1 (Mus musculus)
Pain Link Frequency Relevance Heat
imagery 7 92.76 High High
Central nervous system 66 91.24 High High
Inflammation 24 81.48 Quite High
Pain 2 80.72 Quite High
Potency 11 79.36 Quite High
Arthritis 1 75.80 Quite High
cytokine 22 64.00 Quite High
addiction 2 50.00 Quite Low
tolerance 7 41.76 Quite Low
alcohol 1 22.40 Low Low
Disease Link Frequency Relevance Heat
Stress 178 100.00 Very High Very High Very High
Cancer 43 99.04 Very High Very High Very High
Infection 184 98.90 Very High Very High Very High
Necrosis 5 98.80 Very High Very High Very High
Injury 9 97.88 Very High Very High Very High
Apoptosis 108 96.56 Very High Very High Very High
Death 35 91.44 High High
Shock 153 90.52 High High
Malaria 45 89.96 High High
Diabetes Mellitus 131 88.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, tamoxifen induces a slight increase in ERalpha levels in the untransfected cells.
Positive_regulation (induces) of Positive_regulation (increase) of ERalpha
1) Confidence 0.43 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2856549 Disease Relevance 0.41 Pain Relevance 0
Accumulation of unfolded proteins in the ER activates the unfolded protein response (UPR), resulting in transcriptional induction of ER chaperones and proteases in part through activation of XBP1.
Positive_regulation (resulting) of Positive_regulation (induction) of ER
2) Confidence 0.23 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2823686 Disease Relevance 0.84 Pain Relevance 0
One possible explanation for the absence of ER stress gene expression after NV infection was that the microglial isolation procedures employed resulted in elevated ER stress levels that could obscure detection of any virus-induced changes.
Positive_regulation (resulted) of Positive_regulation (elevated) of ER associated with stress and infection
3) Confidence 0.20 Published 2006 Journal Retrovirology Section Body Doc Link PMC1475625 Disease Relevance 0.74 Pain Relevance 0
Eight hours after exposure to 1 mg/kg BPA, ER transactivation could be significantly induced in the embryos.
Positive_regulation (induced) of Positive_regulation (transactivation) of ER in embryos
4) Confidence 0.19 Published 2004 Journal Environ Health Perspect Section Abstract Doc Link PMC1247619 Disease Relevance 0.09 Pain Relevance 0.12
Because ER stress genes were directly induced in FrCasE-infected NIH 3T3 cells in culture, we examined whether similar ER stress gene induction was occurring in infected primary microglial cells in culture.
Spec (whether) Positive_regulation (occurring) of Spec (whether) Positive_regulation (induction) of ER in microglial cells associated with stress
5) Confidence 0.14 Published 2006 Journal Retrovirology Section Body Doc Link PMC1475625 Disease Relevance 0.61 Pain Relevance 0.09
The accumulation of misfolded mutant proinsulin in the ER leads to activation of the unfolded protein response (UPR) including expression of the pro-apoptotic CHOP gene.
Positive_regulation (leads) of Positive_regulation (accumulation) of ER associated with apoptosis
6) Confidence 0.12 Published 2010 Journal Rev Endocr Metab Disord Section Body Doc Link PMC2974937 Disease Relevance 1.02 Pain Relevance 0.04
It is likely therefore, that the induction of cyclin-A increases activation of associated kinases, even though CDK2 levels were not altered, leading to feedback activation of the estrogen receptor, further suppression of Fas expression, and neuro-protection.
Positive_regulation (leading) of Positive_regulation (activation) of estrogen receptor
7) Confidence 0.12 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC395829 Disease Relevance 0.57 Pain Relevance 0
Tamoxifen treatment induced an increased ER?
Positive_regulation (induced) of Positive_regulation (increased) of ER
8) Confidence 0.06 Published 2003 Journal Reprod Biol Endocrinol Section Body Doc Link PMC156658 Disease Relevance 0 Pain Relevance 0
Many disturbances, including aberrant calcium regulation, altered redox status, or interference with protein glycosylation, can result in the accumulation of unfolded ER client proteins in a phenomenon referred to as ER stress.
Positive_regulation (result) of Positive_regulation (accumulation) of ER associated with stress
9) Confidence 0.06 Published 2008 Journal Current Chemical Genomics Section Body Doc Link PMC2803434 Disease Relevance 0.66 Pain Relevance 0.23
JNK activation is coupled to ER stress–induced IRE-1 activation through recruitment of tumor necrosis factor receptor–associated factor-2 and apotosis signal–regulating kinase-1 to the cytosolic leaflet of the ER membrane (22).
Positive_regulation (induced) of Positive_regulation (activation) of ER in leaflet associated with stress, necrosis and cancer
10) Confidence 0.06 Published 2008 Journal Diabetes Section Body Doc Link PMC2518495 Disease Relevance 0.75 Pain Relevance 0.04
If GRP78 were not up-regulated, ER stress would result in more marked ER accumulation of unfolded proteins and more severe hepatocellular injury.
Positive_regulation (result) of Positive_regulation (accumulation) of ER associated with stress and injury
11) Confidence 0.05 Published 2010 Journal Malar J Section Body Doc Link PMC2858213 Disease Relevance 1.37 Pain Relevance 0

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