INT173747

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Context Info
Confidence 0.37
First Reported 2003
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 4
Total Number 6
Disease Relevance 4.85
Pain Relevance 0.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

enzyme binding (Esr1) DNA binding (Esr1) protein complex (Esr1)
cytoplasm (Esr1) lipid binding (Esr1) nucleus (Esr1)
Anatomy Link Frequency
retina 4
neurons 2
epithelial cell 2
Esr1 (Mus musculus)
Pain Link Frequency Relevance Heat
dexamethasone 5 94.00 High High
agonist 34 91.16 High High
Arthritis 88 84.36 Quite High
ischemia 26 83.84 Quite High
nMDA receptor antagonist 4 77.72 Quite High
Inflammation 46 77.52 Quite High
antagonist 10 77.12 Quite High
rheumatoid arthritis 40 69.00 Quite High
cytokine 28 66.72 Quite High
Inflammatory response 4 50.00 Quite Low
Disease Link Frequency Relevance Heat
Stress 114 99.96 Very High Very High Very High
Hypoxia 146 99.40 Very High Very High Very High
Drug Induced Neurotoxicity 6 99.06 Very High Very High Very High
Ocular Hypertension 42 98.08 Very High Very High Very High
Death 62 97.88 Very High Very High Very High
Endometriosis (extended) 9 93.72 High High
Parkinson's Disease 4 91.88 High High
Hypersensitivity 26 87.08 High High
Juvenile Chronic Polyarthritis 4 84.36 Quite High
Cv Unclassified Under Development 22 83.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For ERB-79, the more sensitive marker of epithelial cell height was used to establish a dose range securing ER?
Regulation (range) of Positive_regulation (securing) of ER in epithelial cell
1) Confidence 0.37 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911889 Disease Relevance 0.78 Pain Relevance 0.45
These mechanisms may contribute to the activation of ER stress in the retina after NMDA stimulation or IOP elevation.
Spec (may) Regulation (contribute) of Positive_regulation (activation) of ER in retina associated with stress and ocular hypertension
2) Confidence 0.20 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2652022 Disease Relevance 1.47 Pain Relevance 0.14
Collectively, the above results indicate that NMDA can cause ER stress in the retina, and that the neurotoxicity induced by NMDA is due in part to a mechanism dependent on CHOP protein induction through excessive ER stress.
Regulation (dependent) of Positive_regulation (induction) of ER in retina associated with stress and drug induced neurotoxicity
3) Confidence 0.12 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2652022 Disease Relevance 1.07 Pain Relevance 0.04
There was also a strong positive correlation between ESR and IL-6 at baseline, which has previously been observed [35], and, interestingly, the change of ESR during the course of the study was highly correlated with the change of IL-6 and to a lesser degree was inversely correlated with the change of IGF-1.
Regulation (change) of Positive_regulation (change) of ESR
4) Confidence 0.10 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC165058 Disease Relevance 0.79 Pain Relevance 0.28
mRNA determinations corresponds to an XbaI-EcoRI fragment of the 3' untranslated region, derived from an ER?
Regulation (untranslated) of Positive_regulation (derived) of ER
5) Confidence 0.03 Published 2003 Journal Reprod Biol Endocrinol Section Body Doc Link PMC156658 Disease Relevance 0 Pain Relevance 0
Because a significant fraction of the [Ca2+]i response to anoxia in DRG neurons appears to be dependent on ER function (see preceding text and discussion) and because the effects of anoxia are mimicked by electron transport inhibition using cyanide, we sought to test for the possible involvement of cADPR in mediating the Ca2+ response to anoxia.
Spec (appears) Regulation (dependent) of Positive_regulation (dependent) of ER in neurons associated with hypoxia
6) Confidence 0.02 Published 2008 Journal Journal of Neurophysiology Section Body Doc Link PMC2493471 Disease Relevance 0.74 Pain Relevance 0.04

General Comments

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