INT173748

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Context Info
Confidence 0.77
First Reported 2003
Last Reported 2011
Negated 1
Speculated 0
Reported most in Body
Documents 11
Total Number 11
Disease Relevance 5.70
Pain Relevance 0.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

enzyme binding (Esr1) DNA binding (Esr1) protein complex (Esr1)
cytoplasm (Esr1) lipid binding (Esr1) nucleus (Esr1)
Anatomy Link Frequency
MCF-7 1
apoptotic cell 1
reticulum 1
Esr1 (Mus musculus)
Pain Link Frequency Relevance Heat
Potency 14 87.28 High High
antagonist 19 79.44 Quite High
agonist 39 78.40 Quite High
Cholecystokinin 1 71.12 Quite High
Inflammation 95 69.36 Quite High
Hippocampus 16 67.28 Quite High
Arthritis 87 55.68 Quite High
dexamethasone 5 54.32 Quite High
Demyelination 5 51.88 Quite High
Central nervous system 28 50.12 Quite High
Disease Link Frequency Relevance Heat
Stress 103 100.00 Very High Very High Very High
Death 118 99.18 Very High Very High Very High
Diabetes Mellitus 145 99.00 Very High Very High Very High
Apoptosis 153 98.96 Very High Very High Very High
Syndrome 5 95.08 Very High Very High Very High
Ganglion Cysts 24 94.24 High High
Exocrine Pancreatic Insufficiency 1 93.92 High High
Pressure And Volume Under Development 18 90.80 High High
Targeted Disruption 65 90.44 High High
Frailty 31 90.12 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
-/- mice [35] or a lack of ER?
Neg (lack) Phosphorylation (lack) of ER
1) Confidence 0.77 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911889 Disease Relevance 0.67 Pain Relevance 0.19
Although this 36-kDa variant of ER?
Phosphorylation (variant) of ER
2) Confidence 0.69 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2978204 Disease Relevance 0.69 Pain Relevance 0
However, the relationship between ER?
Phosphorylation (relationship) of ER
3) Confidence 0.66 Published 2011 Journal Biol Sex Differ Section Body Doc Link PMC3022636 Disease Relevance 0.53 Pain Relevance 0.11
Additional work demonstrated that palmitoylation of ER?
Phosphorylation (palmitoylation) of ER
4) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2866326 Disease Relevance 0 Pain Relevance 0.07
PERK is an endoplasmic reticulum (ER)-resident kinase that phosphorylates eukaryotic translation initiation factor 2?
Phosphorylation (phosphorylates) of ER in reticulum
5) Confidence 0.27 Published 2007 Journal BMC Cell Biol Section Body Doc Link PMC2072952 Disease Relevance 0.78 Pain Relevance 0.04
Treatment with tunicamycin induced apoptotic cell death in RGC-5 and also induced production of ER stress-related proteins (BiP, the phosphorylated form of eIF2?
Phosphorylation (phosphorylated) of ER in apoptotic cell associated with stress, apoptosis and death
6) Confidence 0.27 Published 2007 Journal Molecular Vision Section Abstract Doc Link PMC2652022 Disease Relevance 1.25 Pain Relevance 0
It has already been described that HER-2 transfected MCF-7 cells are tamoxifen resistant but HER-2 overexpression/stimulation leads to ER downregulation, increased phosphorylation and also increased transcriptional activation [37-39].
Phosphorylation (phosphorylation) of ER in MCF-7
7) Confidence 0.27 Published 2008 Journal Int Semin Surg Oncol Section Body Doc Link PMC2383915 Disease Relevance 0.20 Pain Relevance 0.06
EC50 values for ER-?
Phosphorylation (values) of ER
8) Confidence 0.27 Published 2004 Journal Environ Health Perspect Section Body Doc Link PMC1247619 Disease Relevance 0.17 Pain Relevance 0.08
Additionally, cyclin-A complexes with CDK2 to induce phosphorylation of ER-alpha on serines 104 and 106, and consequent transactivation [86].
Phosphorylation (phosphorylation) of ER-alpha
9) Confidence 0.16 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC395829 Disease Relevance 0.66 Pain Relevance 0
By contrast, the C96Y PNDM-associated mutant proinsulin is localized to the expanded ER and is not transported from the ER to the Golgi and packaged into secretory granules
Phosphorylation (expanded) of ER associated with diabetes mellitus
10) Confidence 0.15 Published 2010 Journal Rev Endocr Metab Disord Section Body Doc Link PMC2974937 Disease Relevance 0.60 Pain Relevance 0
The ratio of ER?
Phosphorylation (ratio) of ER
11) Confidence 0.07 Published 2003 Journal Reprod Biol Endocrinol Section Body Doc Link PMC156658 Disease Relevance 0.13 Pain Relevance 0

General Comments

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