INT173752

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Context Info
Confidence 0.57
First Reported 2003
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 6
Disease Relevance 2.21
Pain Relevance 0.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Ghr) extracellular space (Ghr) extracellular region (Ghr)
plasma membrane (Ghr) nucleus (Ghr) cytoplasm (Ghr)
Anatomy Link Frequency
uterine 1
Ghr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 208 95.96 Very High Very High Very High
Inflammation 8 52.20 Quite High
ischemia 4 46.00 Quite Low
imagery 2 44.52 Quite Low
analgesia 8 5.00 Very Low Very Low Very Low
agonist 8 5.00 Very Low Very Low Very Low
antagonist 8 5.00 Very Low Very Low Very Low
anesthesia 6 5.00 Very Low Very Low Very Low
ketamine 4 5.00 Very Low Very Low Very Low
Buprenorphine 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Sepsis 148 98.96 Very High Very High Very High
Starvation 20 98.96 Very High Very High Very High
Hyperplasia 2 93.48 High High
Endometrial Cancer 16 88.56 High High
Critical Illness 36 58.32 Quite High
INFLAMMATION 8 52.20 Quite High
Peritonitis 4 51.28 Quite High
Ileus 8 47.68 Quite Low
Cv General 4 Under Development 4 46.88 Quite Low
Cancer 4 43.36 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, hepatic mRNA of the GHR was increased with both PN and EN.
Positive_regulation (increased) of GHR
1) Confidence 0.57 Published 2007 Journal Crit Care Section Body Doc Link PMC2206515 Disease Relevance 0.39 Pain Relevance 0.07
These differences in SOCS expression appeared independent of the induction of mRNA of the GHR or of IGF-I.
Positive_regulation (induction) of GHR
2) Confidence 0.50 Published 2007 Journal Crit Care Section Body Doc Link PMC2206515 Disease Relevance 0.45 Pain Relevance 0.14
Key messages

• The route of administration of nutrition (parenteral versus enteral) in sepsis influences circulating levels of IL-6 and IL-10 in rodents. • Sepsis and the route of nutrition influence mRNA of SOCS proteins, CIS and SOCS-2, whereas SOCS-3 mRNA is increased in sepsis independent of nutrition. • Provision of nutrition increased mRNA of the GHR and of IGF-I. • These findings suggest that provision of nutrition and the route of delivery of nutrition in sepsis can influence circulatory and cellular mechanisms that link cytokines and the GH–IGF-I axis

Abbreviations

Positive_regulation (increased) of GHR associated with sepsis and cytokine
3) Confidence 0.38 Published 2007 Journal Crit Care Section Body Doc Link PMC2206515 Disease Relevance 0.61 Pain Relevance 0.17
The MNE of mRNA for the GHR was increased by feeding compared with starvation for both CLP and sham-operated animals, but there was no difference comparing PN with EN in either of the surgical groups (Figure 4).


Positive_regulation (increased) of GHR associated with starvation
4) Confidence 0.34 Published 2007 Journal Crit Care Section Body Doc Link PMC2206515 Disease Relevance 0.42 Pain Relevance 0.04
The GH-receptor mRNA level was increased in the uteri of the animals that were treated with E2 as compared to the ICI group (Fig. 1).
Positive_regulation (increased) of GH-receptor
5) Confidence 0.18 Published 2003 Journal Reprod Biol Endocrinol Section Body Doc Link PMC156658 Disease Relevance 0 Pain Relevance 0
The wet weight of the uteri showed a similar pattern as induction of LE height and the GH-receptor mRNA levels, implicating that GH is involved in the regulation of uterine weight.
Positive_regulation (induction) of GH-receptor in uterine
6) Confidence 0.18 Published 2003 Journal Reprod Biol Endocrinol Section Body Doc Link PMC156658 Disease Relevance 0.34 Pain Relevance 0

General Comments

This test has worked.

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