INT173754

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Context Info
Confidence 0.06
First Reported 2003
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.04
Pain Relevance 1.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Mki67) nucleolus (Mki67) nucleus (Mki67)
intracellular (Mki67) molecular_function (Mki67) cellular_component (Mki67)
Mki67 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
fluoxetine 124 100.00 Very High Very High Very High
amygdala 236 98.34 Very High Very High Very High
gABA 84 97.36 Very High Very High Very High
antagonist 7 81.08 Quite High
agonist 5 80.48 Quite High
Versed 1 54.32 Quite High
depression 64 50.00 Quite Low
antidepressant 62 50.00 Quite Low
GABA receptor 14 10.64 Low Low
sSRI 16 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Anxiety Disorder 182 98.78 Very High Very High Very High
Delayed Puberty 1 69.80 Quite High
Targeted Disruption 12 65.24 Quite High
Depression 66 50.00 Quite Low
Disease 1 30.24 Quite Low
Endometriosis (extended) 1 29.32 Quite Low
Advanced Or Metastatic Breast Cancer 1 28.56 Quite Low
Neurodegenerative Disease 48 17.76 Low Low
Endometrial Cancer 8 10.48 Low Low
Breast Cancer 3 7.12 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effects on the proliferation markers PCNA (proliferating cell nuclear antigen) and Ki-67, as assessed by immunohistochemistry, were also studied.
Regulation (effects) of Ki-67
1) Confidence 0.06 Published 2003 Journal Reprod Biol Endocrinol Section Body Doc Link PMC156658 Disease Relevance 0.14 Pain Relevance 0.18
Furthermore, as the beta weights show in Figure 4, specifically in the BLA lesion group, anxiety indirectly related to increased FST immobility via opposite regulation of Ki67 and BrdU (total and indirect effect breakdown, see Table S5).
Regulation (regulation) of Ki67 associated with anxiety disorder and amygdala
2) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2799663 Disease Relevance 0.60 Pain Relevance 0.65
Bicuculline did not affect the total number of Ki-67-positive cells (61.72±3.50), however, it significantly decreased GABA-mediated increases in Ki-67-positive cells (60.44±1.95).
Neg (not) Regulation (affect) of Ki-67 associated with gaba
3) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2994757 Disease Relevance 0 Pain Relevance 0.33
As frequently reported in the literature, in this model including all animals and experimental conditions, we confirm similar positive effects of fluoxetine treatment on levels of both Ki67-IR cells and BrdU-IR cells, as well as a negative effect of fluoxetine on immobility time in the FST.
Regulation (effects) of Ki67 associated with fluoxetine
4) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2799663 Disease Relevance 0.31 Pain Relevance 0.46

General Comments

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