INT173788

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Context Info
Confidence 0.55
First Reported 2003
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 6
Disease Relevance 1.94
Pain Relevance 0.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Hoxa9) DNA binding (Hoxa9) cytoplasm (Hoxa9)
Anatomy Link Frequency
duct 2
bone marrow 1
myeloid cells 1
hematopoietic cells 1
Hoxa9 (Mus musculus)
Pain Link Frequency Relevance Heat
Nerve growth factor 3 78.96 Quite High
Sciatic nerve 3 71.96 Quite High
Peripheral nerve injury 3 50.00 Quite Low
Neuropeptide 2 43.20 Quite Low
endometriosis 4 5.96 Low Low
Central nervous system 16 5.00 Very Low Very Low Very Low
Peripheral nervous system 9 5.00 Very Low Very Low Very Low
anesthesia 8 5.00 Very Low Very Low Very Low
Spinal cord 6 5.00 Very Low Very Low Very Low
cva 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Acute Myeloid Leukemia 16 99.30 Very High Very High Very High
Leukemia 20 97.46 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 4 87.72 High High
Injury 9 84.68 Quite High
Deafness 1 63.92 Quite High
Congenital Anomalies 9 63.40 Quite High
Syndrome 23 58.72 Quite High
Nervous System Injury 4 50.00 Quite Low
Aplasia 4 44.16 Quite Low
Ovarian Cancer 4 7.12 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Indeed, HOXA7 [15], HOXA9 to HOXA13 [16], as well as HOXD9 to HOXD13 [17], are expressed along the differentiating Müllerian duct.
Gene_expression (expressed) of HOXA9 in duct
1) Confidence 0.55 Published 2006 Journal J Negat Results Biomed Section Body Doc Link PMC1444933 Disease Relevance 0.19 Pain Relevance 0
Studies demonstrated that MEIS1 gene and HOXA9-13 genes are co-expressed throughout Müllerian duct differentiation (Dintilhac et al., 2005), which suggests that MEIS1 might play a role in embryonic female genital tract development.
Gene_expression (expressed) of HOXA9 in duct
2) Confidence 0.41 Published 2008 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2387222 Disease Relevance 0.09 Pain Relevance 0
HOXA9 expression was found to cause transformation of normal hematopoietic cells to AML cells only when expressed together with MEIS1 (Kroon et al., 1998).
Gene_expression (expression) of HOXA9 in hematopoietic cells associated with acute myeloid leukemia
3) Confidence 0.41 Published 2008 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2387222 Disease Relevance 0.53 Pain Relevance 0
Specifically, MEIS1 expression is vital for keeping HOXA9-immortalized myeloid cells in an undifferentiated, proliferating state, refractory to granulocyte-colony stimulating factor-induced terminal differentiation (Calvo et al., 2001).
Gene_expression (myeloid cells) of HOXA9-immortalized in myeloid cells
4) Confidence 0.35 Published 2008 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2387222 Disease Relevance 0.51 Pain Relevance 0
Also in human leukemia, high expression of MEIS1 was found in bone marrow cells of acute myelogenous leukemia (AML) patients, where it was always co-expressed with HOXA9 (Smith et al., 1997; Lawrence et al., 1999).
Gene_expression (expressed) of HOXA9 in bone marrow associated with leukemia and acute myeloid leukemia
5) Confidence 0.35 Published 2008 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2387222 Disease Relevance 0.53 Pain Relevance 0
In this context, the differential expression of homeobox-genes such as Hox-9 might recapitulate their role during embryonic ontogenesis.
Gene_expression (expression) of Hox-9
6) Confidence 0.09 Published 2003 Journal BMC Neurosci Section Body Doc Link PMC161801 Disease Relevance 0.08 Pain Relevance 0.15

General Comments

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