INT17379

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Context Info
Confidence 0.64
First Reported 1989
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 7
Disease Relevance 0.58
Pain Relevance 3.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Prlh) lipid metabolic process (Prlh) cytoplasm (Prlh)
Anatomy Link Frequency
medulla oblongata 2
neurons 1
PVN 1
external 1
prefrontal 1
Prlh (Rattus norvegicus)
Pain Link Frequency Relevance Heat
medulla 8 100.00 Very High Very High Very High
Somatostatin 5 100.00 Very High Very High Very High
Analgesic 3 98.62 Very High Very High Very High
Locus ceruleus 8 98.04 Very High Very High Very High
substance P 5 96.86 Very High Very High Very High
Enkephalin 5 96.64 Very High Very High Very High
Potency 3 95.52 Very High Very High Very High
Pain 2 93.28 High High
Paracetamol 6 91.68 High High
Anterior cingulate cortex 2 90.72 High High
Disease Link Frequency Relevance Heat
Chromosome Aberrations 1 93.92 High High
Pain 6 93.28 High High
Affective Disorder 2 51.92 Quite High
Injury 4 36.44 Quite Low
Cognitive Disorder 10 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 6 5.00 Very Low Very Low Very Low
Drug Dependence 4 5.00 Very Low Very Low Very Low
Anxiety Disorder 2 5.00 Very Low Very Low Very Low
Depression 2 5.00 Very Low Very Low Very Low
Urological Neuroanatomy 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PrRP mRNA levels in the medulla oblongata were decreased by ovariectomy and increased by estrogen treatment.
Positive_regulation (increased) of PrRP in medulla oblongata associated with medulla
1) Confidence 0.64 Published 1999 Journal Neurosci. Lett. Section Abstract Doc Link 10624802 Disease Relevance 0 Pain Relevance 0.25
The data indicate that estrogen is prerequisite to the stimulatory effect of PrRP on the secretion of prolactin and to the increase of PrRP mRNA levels in the medulla oblongata.
Positive_regulation (increase) of PrRP in medulla oblongata associated with medulla
2) Confidence 0.64 Published 1999 Journal Neurosci. Lett. Section Abstract Doc Link 10624802 Disease Relevance 0 Pain Relevance 0.25
Focal electrical stimulation of PrH inhibited the spontaneous discharge of 42 of 47 LC neurons; the latency to onset of such inhibition was 19.8 +/- 2.5 msec and its duration was 172.4 +/- 10.4 msec.
Positive_regulation (stimulation) of PrH in neurons associated with locus ceruleus
3) Confidence 0.46 Published 1989 Journal J. Neurosci. Section Abstract Doc Link 2769374 Disease Relevance 0 Pain Relevance 0.72
The results showed that (1) intraventricular injection (icv) of anti-arginine vasopressin (AVP) serum completely reversed pain threshold increase induced by l-glutamate sodium (Glu) injection into the PVN, and local administration (icv) of anti-leucine-enkephalin (L-Ek) serum or anti-beta-endorphin (beta-Ep) serum partly attenuated pain threshold increase induced by Glu injection into the PVN, but pre-treatment of anti-oxytocin (OXT), dynorphinA(1-13) (DynA(1-13)), cholecystokinin-like peptide (CCK), neurotensin (NT), corticotrophin-releasing hormone (CRH), adrenocorticotrophin (ACTH), somatostatin (SST), prolactin-releasing hormone (PRH), angiotensinII (AngII), vasoactive intestinal polypeptide (VIP), melanotropin-releasing hormone (MRH), thyrotropin-releasing hormone (TRH), substance P (SP) or growth hormone-releasing hormone (GHRH) serum (icv) did not influence the analgesic effect of PVN administration with Glu; (2) PVN stimulation with Glu elevated the concentrations of AVP, OXT, CCK, NT, CRH, SST, PRH and DynA(1-13) in PVN perfusion liquid, and could not change the concentrations of L-Ek, beta-Ep, AngII, ACTH, VIP, MRH, TRH, SP and GHRH in PVN perfusion liquid; (3) Pain stimulation increased the concentrations of AVP, L-Ek, beta-Ep, DynA(1-13), CRH and ACTH in PVN perfusion liquid, and did not alter the concentrations of OXT, CCK, NT, SST, PRH, AngII, VIP, MRH, TRH, SP and GHRH in PVN perfusion liquid.
Positive_regulation (elevated) of PRH in PVN associated with pain, glutamate, pain threshold, analgesic, somatostatin, enkephalin, cholecystokinin and substance p
4) Confidence 0.41 Published 2007 Journal Neuropeptides Section Abstract Doc Link 17316791 Disease Relevance 0.44 Pain Relevance 1.57
Remarkably, the substantially increased LA density in PRh stands in contrast to a severe decrease in prefrontal Cg1.
Positive_regulation (increased) of PRh in prefrontal
5) Confidence 0.33 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2754524 Disease Relevance 0.05 Pain Relevance 0.13
The greatest effects were observed following continuous treatment with PRH activation and without external metabolization.
Positive_regulation (activation) of PRH in external
6) Confidence 0.31 Published 1991 Journal Mutat. Res. Section Abstract Doc Link 1904550 Disease Relevance 0.09 Pain Relevance 0.75
In contrast, density values of the limbic area PRh were found to be increased in IR-animals compared with ER-controls in layer V (P = .045; Figure 5(b)).

4.

Positive_regulation (increased) of PRh
7) Confidence 0.31 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2754524 Disease Relevance 0 Pain Relevance 0

General Comments

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