INT173793

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Context Info
Confidence 0.50
First Reported 2003
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 10
Disease Relevance 0.55
Pain Relevance 0.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Gja3) plasma membrane (Gja3)
Anatomy Link Frequency
myocytes 1
glial cells 1
hearts 1
Gja3 (Mus musculus)
Pain Link Frequency Relevance Heat
action potential duration 116 97.66 Very High Very High Very High
potassium channel 314 96.88 Very High Very High Very High
Action potential 54 87.40 High High
Peripheral nerve injury 3 84.16 Quite High
isoflurane 5 59.84 Quite High
anesthesia 9 58.96 Quite High
Spinal cord 6 50.80 Quite High
Kinase C 153 47.60 Quite Low
dexamethasone 1 45.92 Quite Low
ischemia 18 31.96 Quite Low
Disease Link Frequency Relevance Heat
Injury 33 90.24 High High
Nervous System Injury 4 84.16 Quite High
Shock 4 80.72 Quite High
Targeted Disruption 57 65.88 Quite High
Cv Unclassified Under Development 283 51.28 Quite High
Spinal Cord Injury 1 50.80 Quite High
Parkinson's Disease 464 46.48 Quite Low
Reperfusion Injury 120 36.00 Quite Low
Malignant Neoplastic Disease 5 30.12 Quite Low
Sprains And Strains 5 29.08 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
mice compared with baseline recordings and to controls, suggesting increased ventricular refractoriness in the paced Cx43 mutants.
Positive_regulation (increased) of Cx43
1) Confidence 0.50 Published 2008 Journal American Journal of Physiology - Heart and Circulatory Physiology Section Body Doc Link PMC2614590 Disease Relevance 0 Pain Relevance 0
Interestingly, there was a nonsignificant trend toward increased QTc in the paced Cx43+/?
Positive_regulation (paced) of Cx43
2) Confidence 0.44 Published 2008 Journal American Journal of Physiology - Heart and Circulatory Physiology Section Body Doc Link PMC2614590 Disease Relevance 0 Pain Relevance 0
Follow-up studies were also performed in Cx43+/?
Positive_regulation (performed) of Cx43
3) Confidence 0.44 Published 2008 Journal American Journal of Physiology - Heart and Circulatory Physiology Section Body Doc Link PMC2614590 Disease Relevance 0 Pain Relevance 0.09
As our laboratory has previously demonstrated (9), APD was significantly shorter and steady-state and inward rectifier potassium currents (Iss and IK1, respectively) were increased in Cx43+/?
Positive_regulation (increased) of Cx43 associated with action potential duration
4) Confidence 0.40 Published 2008 Journal American Journal of Physiology - Heart and Circulatory Physiology Section Body Doc Link PMC2614590 Disease Relevance 0.12 Pain Relevance 0.23
Iss is increased in unpaced Cx43+/?
Positive_regulation (increased) of Cx43
5) Confidence 0.40 Published 2008 Journal American Journal of Physiology - Heart and Circulatory Physiology Section Body Doc Link PMC2614590 Disease Relevance 0 Pain Relevance 0.09
Furthermore, following more extensive experiments in which we determined the extent of sarcolemmal contamination of mitochondria by measuring the presence of MCT1, we were unable to confirm any consistent increase in the Cx43 associating with the mitochondrial fraction following IP (Fig. 4).
Positive_regulation (increase) of Cx43
6) Confidence 0.16 Published 2007 Journal Biochimica et Biophysica Acta Section Body Doc Link PMC2212780 Disease Relevance 0 Pain Relevance 0
Since myocytes from the Cx43-deficient mice did not show any diazoxide-induced ROS formation [247], this is likely to involve a ROS-mediated signalling pathway, although the mechanism linking Cx43 to ROS production is unclear.
Positive_regulation (linking) of Cx43 in myocytes
7) Confidence 0.13 Published 2007 Journal Biochimica et Biophysica Acta Section Body Doc Link PMC2212780 Disease Relevance 0.07 Pain Relevance 0.04
From their data, Garcia-Dorado and colleagues propose that recruitment of Cx43 to the mitochondria in IP might be required for opening of the mitochondrial KATP channel leading to ROS production that triggers preconditioning [255,257].
Positive_regulation (recruitment) of Cx43 associated with potassium channel
8) Confidence 0.13 Published 2007 Journal Biochimica et Biophysica Acta Section Body Doc Link PMC2212780 Disease Relevance 0.08 Pain Relevance 0.05
Thus the relevance of Cx43 translocation to the mitochondria remains uncertain, although the loss of preconditioning in Cx43-deficient hearts from mice argues strongly for some pool of Cx43 playing a critical role [247,261].
Positive_regulation (argues) of Cx43 in hearts
9) Confidence 0.11 Published 2007 Journal Biochimica et Biophysica Acta Section Body Doc Link PMC2212780 Disease Relevance 0.05 Pain Relevance 0.03
Connexin-43 (Cx-43) has already been reported to be up-regulated in glial cells surrounding axotomized facial nucleus neurons.
Positive_regulation (up-regulated) of Cx-43 in glial cells
10) Confidence 0.05 Published 2003 Journal BMC Neurosci Section Body Doc Link PMC161801 Disease Relevance 0.23 Pain Relevance 0.07

General Comments

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