INT173794

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Context Info
Confidence 0.12
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.39
Pain Relevance 0.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Maf) DNA binding (Maf) cytoplasm (Maf)
Anatomy Link Frequency
chondrocytes 1
Th2 cells 1
Maf (Mus musculus)
Pain Link Frequency Relevance Heat
Osteoarthritis 91 97.88 Very High Very High Very High
Nerve growth factor 3 94.00 High High
metalloproteinase 3 88.40 High High
Sciatic nerve 3 87.00 High High
Neuropeptide 2 58.24 Quite High
Inflammation 98 52.48 Quite High
Arthritis 1 51.44 Quite High
Peripheral nerve injury 3 50.00 Quite Low
cytokine 97 46.48 Quite Low
Pain 1 16.92 Low Low
Disease Link Frequency Relevance Heat
Targeted Disruption 21 100.00 Very High Very High Very High
Injury 9 99.72 Very High Very High Very High
Osteoarthritis 96 97.88 Very High Very High Very High
Hypertrophy 5 79.68 Quite High
Asthma 315 76.80 Quite High
Pressure And Volume Under Development 2 73.24 Quite High
Eosinophilia 19 60.20 Quite High
Hyperplasia 9 57.60 Quite High
Arthritis 1 52.48 Quite High
Nervous System Injury 4 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
C-maf is known to be expressed during embryogenesis and is involved in cell differentiation.
Gene_expression (expressed) of C-maf
1) Confidence 0.12 Published 2003 Journal BMC Neurosci Section Body Doc Link PMC161801 Disease Relevance 0.10 Pain Relevance 0.21
Expression of osteocalcin, alkaline phosphatase, c-maf, Runx2 and type X collagen has been demonstrated in OA chondrocytes [1-5].
Gene_expression (Expression) of c-maf in chondrocytes associated with osteoarthritis
2) Confidence 0.08 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875624 Disease Relevance 0.95 Pain Relevance 0.47
In animals c-maf is a Th2 cell-specific transcription factor, which promotes the differentiation of Th2 cells mainly by an IL-4-dependent mechanism [132]. c-maf-transgenic mice produce higher serum levels of IgE and IgG1, and their Th cells spontaneously developed into Th2 cells in vitro[133].
Gene_expression (produce) of c-maf in Th2 cells associated with targeted disruption
3) Confidence 0.07 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.35 Pain Relevance 0

General Comments

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