INT173796

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Context Info
Confidence 0.56
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 1.41
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Stat5a) nucleus (Stat5a) DNA binding (Stat5a)
cytoplasm (Stat5a) signal transducer activity (Stat5a)
Anatomy Link Frequency
spleens 2
Stat5a (Mus musculus)
Pain Link Frequency Relevance Heat
Peripheral nerve injury 3 50.00 Quite Low
fibrosis 6 22.40 Low Low
cva 5 17.12 Low Low
Central nervous system 21 5.00 Very Low Very Low Very Low
cytokine 9 5.00 Very Low Very Low Very Low
Peripheral nervous system 9 5.00 Very Low Very Low Very Low
Spinal cord 6 5.00 Very Low Very Low Very Low
anesthesia 6 5.00 Very Low Very Low Very Low
dexamethasone 5 5.00 Very Low Very Low Very Low
Parenteral administration 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Myeloid Leukemia 87 99.84 Very High Very High Very High
Lymphatic System Cancer 22 99.84 Very High Very High Very High
Cancer 56 84.44 Quite High
Leukemia 21 77.84 Quite High
Apoptosis 12 74.08 Quite High
Erythrocytosis 70 53.44 Quite High
Myelofibrosis 38 52.16 Quite High
Colon Cancer 5 50.56 Quite High
Nervous System Injury 4 50.00 Quite Low
Philadelphia Chromosome 13 45.32 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
There was constitutive activation of Stat5 and detectable expression of the Stat5 target Bcl-XL in BM of both normal and polycythemic mice, with increased Stat5 phosphorylation and Bcl-XL in spleens from JAKV617F recipients, although this could in part reflect the increase in splenic myeloerythroid cells in these mice.
Gene_expression (expression) of Stat5 in spleens
1) Confidence 0.56 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762384 Disease Relevance 0.21 Pain Relevance 0
There was constitutive activation of Stat5 and detectable expression of the Stat5 target Bcl-XL in BM of both normal and polycythemic mice, with increased Stat5 phosphorylation and Bcl-XL in spleens from JAKV617F recipients, although this could in part reflect the increase in splenic myeloerythroid cells in these mice.
Gene_expression (expression) of Stat5 in spleens
2) Confidence 0.49 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762384 Disease Relevance 0.16 Pain Relevance 0
They found higher levels of activated STAT1, STAT3, and STAT5 in lymphoma cell lines that poorly responded to Vorinostat treatment compared to sensitive cell lines.
Gene_expression (levels) of STAT5 associated with lymphatic system cancer
3) Confidence 0.19 Published 2010 Journal Clinical Epigenetics Section Body Doc Link PMC3020651 Disease Relevance 0.38 Pain Relevance 0
The differential expression of transferrin receptor, P4-kinase, STAT-5 and connexin-43 confirm already published studies from other research groups [16,33-35].
Gene_expression (expression) of STAT-5
4) Confidence 0.09 Published 2003 Journal BMC Neurosci Section Body Doc Link PMC161801 Disease Relevance 0 Pain Relevance 0
Potent Src inhibitory activity of dasatinib in CML progenitors involves BCR-ABL–dependent and BCR-ABL–independent Src activity.30 Dasatinib also inhibits downstream signaling pathways in CML progenitors,30 as well as P-mitogen-activated protein kinase (MAPK), P-Akt, and P-STAT5 levels in CML progenitors in the absence but not in the presence of growth factors.
Gene_expression (levels) of P-STAT5 associated with myeloid leukemia
5) Confidence 0.07 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2697539 Disease Relevance 0.66 Pain Relevance 0

General Comments

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