INT173808

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Context Info
Confidence 0.68
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 35
Total Number 39
Disease Relevance 23.70
Pain Relevance 7.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (CYP27A1) small molecule metabolic process (CYP27A1)
Anatomy Link Frequency
cartilage 6
spine 3
femur 2
urine 2
neck 2
CYP27A1 (Homo sapiens)
Pain Link Frequency Relevance Heat
spinal inflammation 482 99.48 Very High Very High Very High
Osteoarthritis 668 99.32 Very High Very High Very High
rheumatoid arthritis 197 99.00 Very High Very High Very High
Inflammation 135 97.00 Very High Very High Very High
metalloproteinase 24 94.16 High High
Arthritis 52 93.40 High High
Pain 46 93.40 High High
cytokine 60 79.00 Quite High
cINOD 39 78.12 Quite High
COX-2 inhibitor 39 77.20 Quite High
Disease Link Frequency Relevance Heat
Hypercalcemia 321 100.00 Very High Very High Very High
Advanced Or Metastatic Breast Cancer 26 99.64 Very High Very High Very High
Disease 374 99.60 Very High Very High Very High
Osteoporosis 211 99.56 Very High Very High Very High
Low Back Pain 491 99.48 Very High Very High Very High
Osteoarthritis 585 99.32 Very High Very High Very High
Chronic Hepatitis 46 99.28 Very High Very High Very High
Rheumatoid Arthritis 216 99.00 Very High Very High Very High
Breast Cancer 204 98.64 Very High Very High Very High
Hip Fractures 4 98.64 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
D CTX, representing the oldest form of CTX, were increased 2.4-fold and 1.7-fold in HC+ patients and in NC+ patients compared with NC- patients (Fig. 2).
Positive_regulation (increased) of CTX
1) Confidence 0.68 Published 2003 Journal Breast Cancer Res Section Body Doc Link PMC165019 Disease Relevance 0.23 Pain Relevance 0
Our data demonstrate that urinary CTX-II levels, which specifically indicate degradation of cartilage, are also increased and related to radiographic damage of the spine in patients with AS.
Positive_regulation (increased) of CTX-II in spine associated with spinal inflammation
2) Confidence 0.59 Published 2008 Journal Yonsei Medical Journal Section Body Doc Link PMC2615310 Disease Relevance 1.08 Pain Relevance 0.63
Significant associations of urinary CTX-II level with long-term progression of joint destruction in rheumatoid arthritis and with joint damage in severe osteoarthritis have been reported.9-11 However, the role of this cartilage degradation marker has not been determined in patients with AS, and our study is the first to report a significant correlation between increased urinary CTX-II levels and radiographic damage of the spine in patients with AS.
Positive_regulation (increased) of CTX-II in cartilage associated with spinal inflammation, rheumatoid arthritis and osteoarthritis
3) Confidence 0.59 Published 2008 Journal Yonsei Medical Journal Section Body Doc Link PMC2615310 Disease Relevance 0.79 Pain Relevance 0.57
D CTX) was less increased in HC+ patients and in NC+ patients as compared with NC- patients, with Z scores of 2.2 and 1.0, respectively, for ?
Positive_regulation (increased) of CTX
4) Confidence 0.46 Published 2003 Journal Breast Cancer Res Section Abstract Doc Link PMC165019 Disease Relevance 1.02 Pain Relevance 0
L CTX was highly increased compared with NC- patients (P < 0.01), with Z scores of 3.4 and 2.0, respectively.
Positive_regulation (increased) of CTX
5) Confidence 0.46 Published 2003 Journal Breast Cancer Res Section Abstract Doc Link PMC165019 Disease Relevance 1.05 Pain Relevance 0
Although a trend towards an increase in CTX-I with increasing OA severity was seen in women, it was completely absent in men.
Positive_regulation (increase) of CTX-I associated with osteoarthritis
6) Confidence 0.46 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2902412 Disease Relevance 0.50 Pain Relevance 0.05
When individual Z scores of CTX were calculated for the metastatic breast cancer patients compared with the non-metastatic patients, the ?
Positive_regulation (calculated) of CTX associated with advanced or metastatic breast cancer
7) Confidence 0.43 Published 2003 Journal Breast Cancer Res Section Body Doc Link PMC165019 Disease Relevance 0.23 Pain Relevance 0
D form of CTX was consequently increased in NC+ patients and in HC+ patients 2.2 and 1.5 times, respectively, when compared with NC- patients, and increased 2.4 and 1.6 times, respectively, compared with postmenopausal patients.
Positive_regulation (increased) of CTX
8) Confidence 0.43 Published 2003 Journal Breast Cancer Res Section Body Doc Link PMC165019 Disease Relevance 0.36 Pain Relevance 0
D CTX ratio reflecting the relative contents of age-modified CTX forms was highly increased in HC+ patients (1.5-fold and 1.6-fold compared with NC-patients and with postmenopausal patients, respectively) and in NC+ patients (2.2-fold and 2.4-fold compared with NC- patients and with postmenopausal patients).
Positive_regulation (increased) of CTX associated with metastasis
9) Confidence 0.43 Published 2003 Journal Breast Cancer Res Section Body Doc Link PMC165019 Disease Relevance 0.44 Pain Relevance 0
L CTX form was more increased than the age-modified forms ?
Positive_regulation (increased) of CTX
10) Confidence 0.43 Published 2003 Journal Breast Cancer Res Section Body Doc Link PMC165019 Disease Relevance 0.19 Pain Relevance 0
D form of CTX was consequently increased in NC+ patients and in HC+ patients 2.2 and 1.5 times, respectively, when compared with NC- patients, and increased 2.4 and 1.6 times, respectively, compared with postmenopausal patients.
Positive_regulation (increased) of CTX
11) Confidence 0.43 Published 2003 Journal Breast Cancer Res Section Body Doc Link PMC165019 Disease Relevance 0.29 Pain Relevance 0
CTX fragments derived from newly synthesised collagen are of the native peptide form (L-aspartyl peptide [?
Positive_regulation (derived) of CTX
12) Confidence 0.40 Published 2003 Journal Breast Cancer Res Section Body Doc Link PMC165019 Disease Relevance 0.50 Pain Relevance 0
In the present study, an elevated urinary CTX-I level, a marker for bone resorption, was found to reflects increased disease activity and decreased BMD in men with AS.
Positive_regulation (elevated) of CTX-I associated with spinal inflammation, hypercalcemia and disease
13) Confidence 0.40 Published 2008 Journal Yonsei Medical Journal Section Body Doc Link PMC2615310 Disease Relevance 0.89 Pain Relevance 0.36
In summary, urinary CTX-I and CTX-II were elevated in men with AS and correlated well with disease activity, osteoporosis of the femur neck, and radiographic damage of the spine.
Positive_regulation (elevated) of CTX-II in neck associated with spinal inflammation, osteoporosis and disease
14) Confidence 0.40 Published 2008 Journal Yonsei Medical Journal Section Body Doc Link PMC2615310 Disease Relevance 1.26 Pain Relevance 0.64
Elevated urinary CTX-I levels correlated well with BASDAI, femoral BMD, and femoral T score (p < 0.05), and elevated urinary CTX-II levels correlated well with spinal BASRI (p < 0.05) in patients with AS.
Positive_regulation (elevated) of CTX-II in spinal associated with spinal inflammation
15) Confidence 0.40 Published 2008 Journal Yonsei Medical Journal Section Abstract Doc Link PMC2615310 Disease Relevance 0.88 Pain Relevance 0.64
In summary, urinary CTX-I and CTX-II were elevated in men with AS and correlated well with disease activity, osteoporosis of the femur neck, and radiographic damage of the spine.
Positive_regulation (elevated) of CTX-I in neck associated with spinal inflammation, osteoporosis and disease
16) Confidence 0.40 Published 2008 Journal Yonsei Medical Journal Section Body Doc Link PMC2615310 Disease Relevance 1.26 Pain Relevance 0.65
Elevated CTX-I reflects disease activity and loss of femoral BMD while elevated CTX-II levels correlate well with radiographic damage of the spine, suggesting the usefulness of these markers for monitoring disease activity, loss of BMD, and radiographic damage in men with AS.



Positive_regulation (elevated) of CTX-II in spine associated with spinal inflammation and disease
17) Confidence 0.40 Published 2008 Journal Yonsei Medical Journal Section Abstract Doc Link PMC2615310 Disease Relevance 0.78 Pain Relevance 0.53
Levels of both CTX-II and CTX-I, as markers of cartilage and bone degradation respectively, decreased by approximately 50% in the treatment group compared with baseline, and CTX-II levels were restored to premenopausal levels.
Positive_regulation (restored) of CTX-I in cartilage
18) Confidence 0.35 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2902412 Disease Relevance 0.51 Pain Relevance 0.19
Levels of both CTX-II and CTX-I, as markers of cartilage and bone degradation respectively, decreased by approximately 50% in the treatment group compared with baseline, and CTX-II levels were restored to premenopausal levels.
Positive_regulation (restored) of CTX-II in cartilage
19) Confidence 0.35 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2902412 Disease Relevance 0.42 Pain Relevance 0.15
Levels of both CTX-II and CTX-I, as markers of cartilage and bone degradation respectively, decreased by approximately 50% in the treatment group compared with baseline, and CTX-II levels were restored to premenopausal levels.
Positive_regulation (restored) of CTX-II in cartilage
20) Confidence 0.35 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2902412 Disease Relevance 0.51 Pain Relevance 0.19

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