INT173809

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Context Info
Confidence 0.01
First Reported 2003
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.21
Pain Relevance 0.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

RNA binding (TRMT2A)
Anatomy Link Frequency
cartilage 1
TRMT2A (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 35 98.52 Very High Very High Very High
cytokine 3 76.52 Quite High
rheumatoid arthritis 3 52.44 Quite High
Pain 4 5.00 Very Low Very Low Very Low
metalloproteinase 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypercalcemia 21 99.68 Very High Very High Very High
Metastasis 150 99.56 Very High Very High Very High
Breast Cancer 51 98.96 Very High Very High Very High
Osteoarthritis 36 98.52 Very High Very High Very High
Reprotox - General 1 3 88.64 High High
Rheumatic Diseases 1 65.48 Quite High
Rheumatoid Arthritis 3 52.44 Quite High
Bone Disease 9 51.40 Quite High
Cancer 9 37.84 Quite Low
Apoptosis 14 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, using a specific immunoassay measuring the C telopeptide of type II collagen fragments on OA cartilage explants, we also found that the level of the cleaved collagen fragments were significantly increased in the presence of both IL-1?
Positive_regulation (increased) of fragments in cartilage associated with osteoarthritis
1) Confidence 0.01 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065327 Disease Relevance 0.34 Pain Relevance 0.18
CTX fragments derived from newly synthesised collagen are of the native peptide form (L-aspartyl peptide [?
Positive_regulation (derived) of fragments
2) Confidence 0.01 Published 2003 Journal Breast Cancer Res Section Body Doc Link PMC165019 Disease Relevance 0.49 Pain Relevance 0
Breast cancer patients with bone metastases are characterised by increased levels of nonisomerised type I collagen fragments

Background

Positive_regulation (increased) of fragments associated with breast cancer and metastasis
3) Confidence 0.01 Published 2003 Journal Breast Cancer Res Section Title Doc Link PMC165019 Disease Relevance 0.87 Pain Relevance 0
Fragments of collagen type I containing the epitope AHDGGR (CTX) are generated during bone resorption.
Positive_regulation (generated) of Fragments associated with hypercalcemia
4) Confidence 0.01 Published 2003 Journal Breast Cancer Res Section Abstract Doc Link PMC165019 Disease Relevance 0.50 Pain Relevance 0

General Comments

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