INT17381

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Context Info
Confidence 0.78
First Reported 1982
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 146
Total Number 148
Disease Relevance 65.01
Pain Relevance 34.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Tbxa2r) plasma membrane (Tbxa2r) signal transducer activity (Tbxa2r)
Anatomy Link Frequency
platelet 47
plasma 6
blood 3
liver 3
endothelial cells 3
Tbxa2r (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 69 100.00 Very High Very High Very High
adenocard 49 100.00 Very High Very High Very High
agonist 374 99.96 Very High Very High Very High
aspirin 1133 99.80 Very High Very High Very High
Angina 172 99.80 Very High Very High Very High
cva 96 99.70 Very High Very High Very High
ischemia 64 99.68 Very High Very High Very High
headache 23 99.68 Very High Very High Very High
cOX1 21 99.68 Very High Very High Very High
COX-2 inhibitor 146 99.62 Very High Very High Very High
Disease Link Frequency Relevance Heat
Renal Disease 16 100.00 Very High Very High Very High
Stroke 72 99.92 Very High Very High Very High
Cv General 3 Under Development 239 99.80 Very High Very High Very High
Cv Unclassified Under Development 50 99.68 Very High Very High Very High
Headache 31 99.68 Very High Very High Very High
Stress 235 99.66 Very High Very High Very High
Increased Venous Pressure Under Development 219 99.66 Very High Very High Very High
Coronary Heart Disease 114 99.54 Very High Very High Very High
Acute Coronary Syndrome 64 99.48 Very High Very High Very High
Injury 51 99.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The plasma 11-dehydrothromboxane B2 (11-dTXB2) is free from artifactual increase during blood sampling, and it can be a reliable indicator of thromboxane A2 (TXA2) production in vivo.
Gene_expression (production) of TXA2 in blood
1) Confidence 0.78 Published 1994 Journal Headache Section Abstract Doc Link 8002323 Disease Relevance 0.89 Pain Relevance 0.89
The plasma 11-dehydrothromboxane B2 (11-dTXB2) is free from artifactual increase during blood sampling, and it can be a reliable indicator of thromboxane A2 (TXA2) production in vivo.
Gene_expression (production) of thromboxane A2 in blood
2) Confidence 0.78 Published 1994 Journal Headache Section Abstract Doc Link 8002323 Disease Relevance 0.89 Pain Relevance 0.89
Percutaneous transluminal coronary angioplasty is associated with transiently enhanced TXA2 biosynthesis and Aspirin-suppressable periprocedural thrombotic complications.
Gene_expression (biosynthesis) of TXA2 associated with aspirin and percutaneous transluminal coronary angioplasty
3) Confidence 0.78 Published 1990 Journal Stroke Section Abstract Doc Link 2260137 Disease Relevance 0.71 Pain Relevance 0.52
The increased TxA2 synthesis and the inappropriate increase of peripheral vascular response to sympathetic stimulation revert back to normal in the inactive phase.
Gene_expression (synthesis) of TxA2 in sympathetic
4) Confidence 0.78 Published 1986 Journal Circulation Section Abstract Doc Link 3948351 Disease Relevance 0.66 Pain Relevance 0.43
TxA2 is synthesized by platelets and contributes to platelet activation and irreversible platelet aggregation in physiological hemostasis and in thrombosis (e.g., unstable angina, stroke).
Gene_expression (synthesized) of TxA2 in platelet associated with angina, stroke and thrombosis
5) Confidence 0.77 Published 1987 Journal Fed. Proc. Section Abstract Doc Link 2948837 Disease Relevance 0.46 Pain Relevance 0.14
The levels of Prostacyclin (PGI2) and Thromboxane A2 (TXA2) were assayed simultaneously (RIA) in the plasma and saliva of 9 patients suffering from classical migraine attacks.
Gene_expression (levels) of Thromboxane A2 in saliva associated with migraine with aura and migraine
6) Confidence 0.75 Published 1991 Journal Headache Section Abstract Doc Link 2071393 Disease Relevance 0.31 Pain Relevance 0.34
The levels of Prostacyclin (PGI2) and Thromboxane A2 (TXA2) were assayed simultaneously (RIA) in the plasma and saliva of 9 patients suffering from classical migraine attacks.
Gene_expression (levels) of TXA2 in saliva associated with migraine with aura and migraine
7) Confidence 0.75 Published 1991 Journal Headache Section Abstract Doc Link 2071393 Disease Relevance 0.31 Pain Relevance 0.34
Since none of the compounds tested produced a sustained inhibition of TXA2 synthesis, the disappointing clinical results with this class of drugs may be due to an incomplete blockade of thromboxane synthase with the dosage regimens used.
Gene_expression (synthesis) of TXA2
8) Confidence 0.75 Published 1990 Journal Circulation Section Abstract Doc Link 2136820 Disease Relevance 0.92 Pain Relevance 0.34
These results suggest that limb ischemia stimulates the TXA2 production, which may be influenced not only by endothelial cell damage and the generation of oxygen free radicals but also by the activation of the sympathetic nervous system.
Gene_expression (production) of TXA2 in sympathetic nervous system associated with ischemia
9) Confidence 0.74 Published 1989 Journal Masui Section Abstract Doc Link 2733138 Disease Relevance 0.24 Pain Relevance 0.29
We also examined the combination of MMF with a selective cyclooxygenase-2 (COX-2) inhibitor, DFU, based on previous findings of excessive renal production of COX-2-derived thromboxane A2 (TXA2) in lupus nephritis.
Gene_expression (production) of TXA2 associated with renal disease
10) Confidence 0.74 Published 2001 Journal Kidney Int. Section Abstract Doc Link 11473648 Disease Relevance 0.60 Pain Relevance 0.08
The drug was found to inhibit thromboxane A2 (TXA2) production ex vivo as determined by radioimmunoassay (RIA) and to reversibly antagonise the effect of TXA2 on smooth vascular tissue.
Gene_expression (production) of TXA2
11) Confidence 0.73 Published 1983 Journal Thromb. Res. Section Abstract Doc Link 6140774 Disease Relevance 0.19 Pain Relevance 0.14
The drug was found to inhibit thromboxane A2 (TXA2) production ex vivo as determined by radioimmunoassay (RIA) and to reversibly antagonise the effect of TXA2 on smooth vascular tissue.
Gene_expression (production) of thromboxane A2
12) Confidence 0.73 Published 1983 Journal Thromb. Res. Section Abstract Doc Link 6140774 Disease Relevance 0.19 Pain Relevance 0.14
Aspirin irreversibly inhibits TXA2 and PGH2 synthesis in platelets, but also reduces the formation of the platelet-inhibiting PGD2 and prostacyclin--even under a low-dose regimen. 2.
Gene_expression (synthesis) of TXA2 in platelet associated with aspirin
13) Confidence 0.71 Published 1990 Journal Z Kardiol Section Abstract Doc Link 2099038 Disease Relevance 0.16 Pain Relevance 0.37
In conclusion, intracoronary administration of a TXA2 synthase inhibitor can relieve ACh-induced coronary spasms by inhibiting TXA2 synthesis in the local coronary circulation.
Gene_expression (synthesis) of TXA2 associated with cva
14) Confidence 0.70 Published 2002 Journal Circ. J. Section Abstract Doc Link 12224820 Disease Relevance 0.79 Pain Relevance 0.34
We conclude that in patients with intermittent claudication due to atherosclerosis (1) platelet activation does not occur during the course of the exercise, and (2) vascular prostacyclin formation can be dissociated from of TxA2 synthesis.
Gene_expression (synthesis) of TxA2 in platelet associated with restless leg syndrome and increased venous pressure under development
15) Confidence 0.69 Published 1988 Journal Clin Physiol Section Abstract Doc Link 3402185 Disease Relevance 0.41 Pain Relevance 0.31
This exaggerated vasoconstrictor response was associated with elevated TxA2 resting levels in plasma and with increased TxA2 synthesis after the cold pressor test.
Gene_expression (synthesis) of TxA2 in plasma
16) Confidence 0.68 Published 1986 Journal Circulation Section Abstract Doc Link 3948351 Disease Relevance 0.84 Pain Relevance 0.53
AA and EPA changes in membrane PC significantly correlated with TxA2 production (p less than 0.001) but not with coronary pathoanatomy.
Gene_expression (production) of TxA2
17) Confidence 0.67 Published 1986 Journal Thromb. Res. Section Abstract Doc Link 3024352 Disease Relevance 0.47 Pain Relevance 0.53
TxA2 is also synthesized in intestinal, pulmonary, and renal tissues by cells other than platelets.
Gene_expression (synthesized) of TxA2 in platelets
18) Confidence 0.67 Published 1987 Journal Fed. Proc. Section Abstract Doc Link 2948837 Disease Relevance 0.76 Pain Relevance 0.14
The eicosapentaenic acid (EPA)-rich diet containing precursors of inactive TxA2 synthesis and the routine hospital diet (No. 10 according to Pevzner) were examined for effects on platelet generation of TxA2 on induction of ADP aggregation in 12 patients with first angina (FA).
Gene_expression (synthesis) of TxA2 in platelet associated with angina
19) Confidence 0.66 Published 1990 Journal Kardiologiia Section Abstract Doc Link 2290264 Disease Relevance 0.54 Pain Relevance 0.40
These data suggest that: in normal subjects TXA2 and PGI2 increase during exercise, PGI2 increasing more than TXA2, and although coronary disease patients have resting TXA2 and PGI2 levels in the normal range, TXA2 levels increase more than PGI2 levels during exercise.
Gene_expression (levels) of TXA2 associated with coronary heart disease
20) Confidence 0.66 Published 1983 Journal Am. Heart J. Section Abstract Doc Link 6344604 Disease Relevance 0.42 Pain Relevance 0.12

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