INT173849

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Context Info
Confidence 0.49
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 8
Disease Relevance 4.60
Pain Relevance 3.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (MMP3) extracellular space (MMP3) extracellular region (MMP3)
proteinaceous extracellular matrix (MMP3) nucleus (MMP3) protein complex (MMP3)
Anatomy Link Frequency
synovium 4
chondrocytes 2
fibroblasts 2
MMP3 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 146 100.00 Very High Very High Very High
Infliximab 198 98.56 Very High Very High Very High
Osteoarthritis 295 98.36 Very High Very High Very High
cytokine 52 97.60 Very High Very High Very High
Inflammation 101 97.24 Very High Very High Very High
Inflammatory mediators 12 84.16 Quite High
corticosteroid 4 82.68 Quite High
Pain 112 82.16 Quite High
spinal inflammation 120 58.60 Quite High
Multiple sclerosis 2 51.24 Quite High
Disease Link Frequency Relevance Heat
Osteoarthritis 163 98.36 Very High Very High Very High
INFLAMMATION 121 97.24 Very High Very High Very High
Synovitis 4 89.24 High High
Cancer 38 84.16 Quite High
Disease 93 84.04 Quite High
Metastasis 1 82.32 Quite High
Pain 122 82.16 Quite High
Pressure And Volume Under Development 6 80.00 Quite High
Aging 28 78.48 Quite High
Apoptosis 18 74.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Figure 3 shows a steep increase in MMP-3 secretion in TNF?
Positive_regulation (increase) of Localization (secretion) of MMP-3
1) Confidence 0.49 Published 2010 Journal International Journal of Medical Sciences Section Body Doc Link PMC2974165 Disease Relevance 0.89 Pain Relevance 0.52
One interesting finding of this study is that preterm and term cervical fibroblasts show different secretion patterns of IL-8, MMP-1 and MMP-3, where IL-8 and MMP-1 are secreted at higher levels in preterm and MMP-3 in term cervical fibroblasts.
Positive_regulation (levels) of Localization (secreted) of MMP-3 in fibroblasts associated with metalloproteinase
2) Confidence 0.38 Published 2008 Journal Molecular Human Reproduction Section Body Doc Link PMC2639405 Disease Relevance 0 Pain Relevance 0.43
induced MMP-3 secretion in chondrocytes; (2) Aflapin inhibits TNF?
Positive_regulation (induced) of Localization (secretion) of MMP-3 in chondrocytes
3) Confidence 0.33 Published 2010 Journal International Journal of Medical Sciences Section Body Doc Link PMC2974165 Disease Relevance 1.12 Pain Relevance 0.70
Synovial levels of matrix metalloproteinase-3 (MMP-3) and tissue inhibitors of matrix metalloproteinases (TIMP) are also elevated in SpA synovium and treatment with infliximab rapidly downregulates synovial expression of MMP-3 and TIMP and serum MMP-3 (Vandooren et al 2004).
Positive_regulation (elevated) of Localization (levels) of matrix metalloproteinase-3 in synovium associated with infliximab and metalloproteinase
4) Confidence 0.23 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721298 Disease Relevance 0.35 Pain Relevance 0.56
Synovial levels of matrix metalloproteinase-3 (MMP-3) and tissue inhibitors of matrix metalloproteinases (TIMP) are also elevated in SpA synovium and treatment with infliximab rapidly downregulates synovial expression of MMP-3 and TIMP and serum MMP-3 (Vandooren et al 2004).
Positive_regulation (elevated) of Localization (levels) of MMP-3 in synovium associated with infliximab and metalloproteinase
5) Confidence 0.20 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721298 Disease Relevance 0.35 Pain Relevance 0.56
Recent studies revealed that senescent cells from preneoplasic tissues also promoted ECM degradation via the secretion of metalloproteinases such as MMP-3 [52].
Positive_regulation (promoted) of Localization (secretion) of MMP-3 associated with metalloproteinase
6) Confidence 0.05 Published 2010 Journal The Open Rheumatology Journal Section Body Doc Link PMC2845788 Disease Relevance 1.30 Pain Relevance 0.38
HA also attenuated the enhanced stromelysin-1 release induced with fragments of fibronectin [64].
Positive_regulation (induced) of Localization (release) of stromelysin-1
7) Confidence 0.01 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC165033 Disease Relevance 0.29 Pain Relevance 0.25
HA also attenuated the enhanced stromelysin-1 release induced with fragments of fibronectin [64].
Positive_regulation (enhanced) of Localization (release) of stromelysin-1
8) Confidence 0.01 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC165033 Disease Relevance 0.29 Pain Relevance 0.25

General Comments

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