INT173850

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Context Info
Confidence 0.48
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 3.32
Pain Relevance 2.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (MMP3) extracellular space (MMP3) extracellular region (MMP3)
proteinaceous extracellular matrix (MMP3) nucleus (MMP3) protein complex (MMP3)
Anatomy Link Frequency
chondrocytes 2
MMP3 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 94 100.00 Very High Very High Very High
Osteoarthritis 225 96.24 Very High Very High Very High
Pain 110 95.00 High High
cytokine 35 94.56 High High
Inflammation 67 94.20 High High
Inflammatory mediators 6 83.52 Quite High
Pain score 36 72.64 Quite High
COX-2 inhibitor 19 69.24 Quite High
cINOD 17 5.00 Very Low Very Low Very Low
Analgesic 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoarthritis 159 96.24 Very High Very High Very High
Pain 140 95.00 High High
INFLAMMATION 81 94.20 High High
Disease 18 90.40 High High
Arthropathy 3 89.84 High High
Breast Cancer 56 84.28 Quite High
Adhesions 18 82.56 Quite High
Metastasis 12 78.88 Quite High
Injury 12 72.48 Quite High
Knee Osteoarthritis 67 63.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Aflapin inhibits secretion of MMP-3 in TNF?
Negative_regulation (inhibits) of Localization (secretion) of MMP-3
1) Confidence 0.48 Published 2010 Journal International Journal of Medical Sciences Section Body Doc Link PMC2974165 Disease Relevance 0.73 Pain Relevance 0.55
g/ml) in inhibiting MMP-3 secretion from TNF?
Negative_regulation (inhibiting) of Localization (secretion) of MMP-3
2) Confidence 0.48 Published 2010 Journal International Journal of Medical Sciences Section Body Doc Link PMC2974165 Disease Relevance 0.85 Pain Relevance 0.44
-induced chondrocytes and dose-dependent inhibition of MMP-3 secretion in 5-Loxin and Aflapin treated cultures.
Negative_regulation (inhibition) of Localization (secretion) of MMP-3 in chondrocytes
3) Confidence 0.48 Published 2010 Journal International Journal of Medical Sciences Section Body Doc Link PMC2974165 Disease Relevance 0.84 Pain Relevance 0.46
After 24 h, there was a 67% decrease in MMP-1, 45% in MMP-2 and 65% in MMP-3 secretion by Hs578T cells treated with 100 ?
Negative_regulation (decrease) of Localization (secretion) of MMP-3 associated with metalloproteinase
4) Confidence 0.06 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1559713 Disease Relevance 0.61 Pain Relevance 0.55
HA also attenuated the enhanced stromelysin-1 release induced with fragments of fibronectin [64].
Negative_regulation (attenuated) of Localization (release) of stromelysin-1
5) Confidence 0.01 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC165033 Disease Relevance 0.29 Pain Relevance 0.25

General Comments

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